Personalis (PSNL) Operating Margin (2018 - 2026)
Personalis' Operating Margin came in at -150.25% for Q2 2026, down 23.50 percentage points from -126.75% a year earlier but up 57.62 percentage points from the prior quarter.
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Analysis
Personalis (PSNL) Operating Margin (2018 - 2026) Analysis & Trends
Over the trailing twelve months to Jun 30, 2026, Personalis reported Operating Margin of -164.07%, down 74.44 percentage points year-over-year; for FY2025, it was -126.43%, down 45.75 percentage points from FY2024.
- Operating Margin carries a five-year change of -72.84 percentage points (FY2020 to FY2025).
- Going back by year, Operating Margin was -80.68% in FY2024 (+68.93 pp), -149.61% in FY2023 (+28.00 pp), -177.61% in FY2022 (-101.17 pp) and -76.44% in FY2021 (-22.85 pp).
- The five-year range for quarterly Operating Margin is -207.87% (Q1 2026) to -55.94% (Q3 2024).
- Year-over-year, Operating Margin has declined for five consecutive quarters, with an average year-over-year change of -25.29 percentage points over the last eight quarters.
- The fastest year-over-year change in Operating Margin over five years came in Q3 2024 (a gain of 112.82 percentage points), and the weakest in Q1 2022 (a drop of 126.08 percentage points).
- Business Quant data shows PSNL's Operating Margin at -207.87% (Q1 2026), -145.67% (Q4 2025) and -160.68% (Q3 2025) in the three quarters before Q2 2026.
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | HCA Healthcare | 101.32 Bn | 97.33 Bn | - | - |
| 2 | Natera | 59.54 Bn | 55.23 Bn | 485.19 Mn | -10.07% |
| 3 | Quest Diagnostics | 26.52 Bn | 24.65 Bn | 1.03 Bn | 15.08% |
| 4 | Labcorp Holdings | 26.44 Bn | 24.19 Bn | 1.11 Bn | 12.10% |
| 5 | Tenet Healthcare | 22.57 Bn | 11.57 Bn | - | 26.67% |
| 6 | Guardant Health | 22.10 Bn | 18.16 Bn | 219.03 Mn | -38.55% |
| 7 | BrightSpring Health Services | 12.95 Bn | 11.28 Bn | 492.75 Mn | 3.37% |
| 8 | Fresenius Medical Care AG | 12.54 Bn | 4.50 Bn | 1.52 Bn | 9.58% |
| 9 | Tempus AI | 12.21 Bn | 9.24 Bn | 246.50 Mn | -19.85% |
| 10 | Personalis | 1.68 Bn | 846.23 Mn | 4.74 Mn | -150.25% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -150.25% |
| Mar 31, 2026 | -207.87% |
| Dec 31, 2025 | -145.67% |
| Sep 30, 2025 | -160.68% |
| Jun 30, 2025 | -126.75% |
| Mar 31, 2025 | -85.88% |
| Dec 31, 2024 | -107.81% |
| Sep 30, 2024 | -55.94% |
| Jun 30, 2024 | -74.81% |
| Mar 31, 2024 | -96.70% |
| Dec 31, 2023 | -121.84% |
| Sep 30, 2023 | -168.76% |
| Jun 30, 2023 | -151.78% |
| Mar 31, 2023 | -158.14% |
| Dec 31, 2022 | -191.87% |
| Sep 30, 2022 | -183.46% |
| Jun 30, 2022 | -152.86% |
| Mar 31, 2022 | -185.89% |
| Dec 31, 2021 | -97.79% |
| Sep 30, 2021 | -79.47% |
API Access
Personalis Operating Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=operating-margin&ticker=PSNL&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "operating-margin", "ticker": "PSNL", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=operating-margin&ticker=PSNL&period=max&api_key=YOUR_API_KEY");
const data = await res.json();