Growth Metrics

Guardant Health (GH) Operating Margin (2017 - 2026)

Guardant Health's Operating Margin history spans 9 years, with the latest figure at 42.95% for Q4 2025.

  • On a quarterly basis, Operating Margin rose 1947.0% to 42.95% in Q4 2025 year-over-year; TTM through Dec 2025 was 44.53%, a 1550.0% increase, with the full-year FY2025 number at 44.53%, up 1550.0% from a year prior.
  • Operating Margin hit 42.95% in Q4 2025 for Guardant Health, down from 37.33% in the prior quarter.
  • Over the last five years, Operating Margin for GH hit a ceiling of 37.33% in Q3 2025 and a floor of 137.12% in Q1 2021.
  • Historically, Operating Margin has averaged 87.58% across 5 years, with a median of 89.03% in 2021.
  • Biggest five-year swings in Operating Margin: tumbled -8540bps in 2021 and later surged 6497bps in 2024.
  • Tracing GH's Operating Margin over 5 years: stood at 90.84% in 2021, then decreased by -27bps to 115.15% in 2022, then decreased by -11bps to 127.38% in 2023, then soared by 51bps to 62.42% in 2024, then surged by 31bps to 42.95% in 2025.
  • Business Quant data shows Operating Margin for GH at 42.95% in Q4 2025, 37.33% in Q3 2025, and 45.85% in Q2 2025.