Guardant Health (GH) Operating Margin (2017 - 2026)
Guardant Health (GH) posted Operating Margin of 40.23% for Q1 2026, up 6.34% sequentially from 42.95% in Q4 2025, and up 1435.0% YoY from 2.62% in Q1 2025.
Guardant Health (GH) Operating Margin (2017 - 2026) Analysis & Trends
Guardant Health (GH) has 10 years of Operating Margin data on file, last reported at 40.23% in Q1 2026.
- Quarterly Operating Margin rose 1435.0% year-over-year to 40.23% in Q1 2026, while the trailing twelve-month figure through Mar 2026 was 41.43% (up 1735.0% YoY) and the FY2025 annual result came in at 44.53%, up 1550.0% from the prior year.
- Operating Margin grew to 40.23% in Q1 2026 per GH's latest filing, from 42.95% in the prior quarter.
- The five-year high for Operating Margin was 37.33% in Q3 2025, with the low at 128.34% in Q1 2022.
- Average Operating Margin over 5 years is 79.1%, with a median of 62.42% recorded in 2024.
- Year-over-year, Operating Margin plunged 2431 bps in 2022 and jumped 6497 bps in 2024.
- Guardant Health's Operating Margin stood at 115.15% in 2022, then dropped by 11 bps to 127.38% in 2023, then surged by 51 bps to 62.42% in 2024, then jumped by 31 bps to 42.95% in 2025, then grew by 6 bps to 40.23% in 2026.
- Business Quant data shows GH's Operating Margin at 40.23% in Q1 2026, 42.95% in Q4 2025, and 37.33% in Q3 2025.
Powered by 
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Waters | 31,055.11 Bn | 31,054.65 Bn | 1.11 Bn | -3.71% |
| 2 | Thermo Fisher Scientific | 191.02 Bn | 187.77 Bn | 7.74 Bn | 16.93% |
| 3 | Danaher | 137.16 Bn | 131.47 Bn | 3.59 Bn | 22.58% |
| 4 | Idexx Laboratories | 42.82 Bn | 42.62 Bn | 722.74 Mn | 31.78% |
| 5 | Natera | 39.09 Bn | 37.99 Bn | 696.04 Mn | -13.42% |
| 6 | Agilent Technologies | 37.61 Bn | 35.81 Bn | 990.00 Mn | 21.74% |
| 7 | Iqvia Holdings | 34.23 Bn | 32.25 Bn | 1.36 Bn | 12.38% |
| 8 | Illumina | 28.14 Bn | 26.98 Bn | 721.00 Mn | 19.16% |
| 9 | Mettler Toledo International | 26.40 Bn | 26.33 Bn | 555.82 Mn | 25.23% |
| 10 | Guardant Health | 22.42 Bn | 21.31 Bn | 196.75 Mn | -40.23% |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -40.23% |
| Dec 31, 2025 | -42.95% |
| Sep 30, 2025 | -37.33% |
| Jun 30, 2025 | -45.85% |
| Mar 31, 2025 | -54.57% |
| Dec 31, 2024 | -62.42% |
| Sep 30, 2024 | -61.28% |
| Jun 30, 2024 | -56.77% |
| Mar 31, 2024 | -59.16% |
| Dec 31, 2023 | -127.38% |
| Sep 30, 2023 | -79.38% |
| Jun 30, 2023 | -87.22% |
| Mar 31, 2023 | -104.15% |
| Dec 31, 2022 | -115.15% |
| Sep 30, 2022 | -123.16% |
| Jun 30, 2022 | -119.40% |
| Mar 31, 2022 | -128.34% |
| Dec 31, 2021 | -90.84% |
| Sep 30, 2021 | -113.20% |
| Jun 30, 2021 | -106.02% |