Personalis (PSNL) Operating Margin (2018 - 2026)
Personalis (PSNL) posted Operating Margin of 150.25% for Q2 2026, up 27.72% on a QoQ basis from 207.87% in Q1 2026, and down 2350.0% year-over-year from 6.68% in Q2 2025.
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Personalis (PSNL) Operating Margin (2018 - 2026) Analysis & Trends
Personalis has reported Operating Margin for 9 years, with the latest figure at 150.25% in Q2 2026.
- On a quarterly basis, Operating Margin fell 2350.0% year-over-year to 150.25% in Q2 2026; TTM through Jun 2026 was 164.07%, a 7444.0% decrease from a year earlier, with the FY2025 full-year figure at 126.43%, down 4575.0% from the prior year.
- Operating Margin was 150.25% for Q2 2026 at Personalis, up from 207.87% in the prior quarter.
- The five-year high for Operating Margin was 55.94% in Q3 2024, with the low at 207.87% in Q1 2026.
- Average Operating Margin over 5 years is 140.39%, with a median of 151.01% recorded in 2023.
- The sharpest annual moves came in 2022 and 2024: Operating Margin plunged 12608 bps in 2022, then soared 11282 bps in 2024.
- Over 5 years, Operating Margin stood at 191.87% in 2022, then surged by 36 bps to 121.84% in 2023, then gained by 12 bps to 107.81% in 2024, then slumped by 35 bps to 145.67% in 2025, then decreased by 3 bps to 150.25% in 2026.
- The last three Operating Margin figures came in at 150.25% (Q2 2026), 207.87% (Q1 2026), and 145.67% (Q4 2025), per Business Quant data.
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Natera | 53.05 Bn | 51.95 Bn | 486.15 Mn | -10.07% |
| 2 | Quest Diagnostics | 27.19 Bn | 26.87 Bn | 1.03 Bn | 15.08% |
| 3 | Labcorp Holdings | 25.93 Bn | 25.81 Bn | 1.11 Bn | 12.10% |
| 4 | Guardant Health | 23.97 Bn | 22.91 Bn | 219.03 Mn | -38.55% |
| 5 | Tempus AI | 13.64 Bn | 12.82 Bn | 274.25 Mn | -19.85% |
| 6 | Caris Life Sciences | 8.47 Bn | 7.68 Bn | 182.38 Mn | 10.21% |
| 7 | Sotera Health | 5.35 Bn | 4.99 Bn | 177.96 Mn | 34.17% |
| 8 | BillionToOne | 4.96 Bn | 4.41 Bn | 77.11 Mn | 5.03% |
| 9 | Adaptive Biotechnologies | 4.55 Bn | 4.21 Bn | 51.39 Mn | -22.04% |
| 10 | Personalis | 1.74 Bn | 1.53 Bn | 4.74 Mn | -150.25% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -150.25% |
| Mar 31, 2026 | -207.87% |
| Dec 31, 2025 | -145.67% |
| Sep 30, 2025 | -160.68% |
| Jun 30, 2025 | -126.75% |
| Mar 31, 2025 | -85.88% |
| Dec 31, 2024 | -107.81% |
| Sep 30, 2024 | -55.94% |
| Jun 30, 2024 | -74.81% |
| Mar 31, 2024 | -96.70% |
| Dec 31, 2023 | -121.84% |
| Sep 30, 2023 | -168.76% |
| Jun 30, 2023 | -151.78% |
| Mar 31, 2023 | -158.14% |
| Dec 31, 2022 | -191.87% |
| Sep 30, 2022 | -183.46% |
| Jun 30, 2022 | -152.86% |
| Mar 31, 2022 | -185.89% |
| Dec 31, 2021 | -97.79% |
| Sep 30, 2021 | -79.47% |
API Access
Personalis Operating Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=operating-margin&ticker=PSNL&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "operating-margin", "ticker": "PSNL", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=operating-margin&ticker=PSNL&period=max&api_key=YOUR_API_KEY");
const data = await res.json();