Personalis (PSNL) Operating Margin (2018 - 2026)
Personalis (PSNL) recorded quarterly Operating Margin of 207.87% in Q1 2026, down 42.7% quarter-over-quarter from 145.67% in Q4 2025, and down 12198.0% on a YoY basis from N/an in Q1 2025.
Personalis (PSNL) Operating Margin (2018 - 2026) Analysis & Trends
Personalis' Operating Margin history runs 9 years deep, the most recent figure standing at 207.87% for Q1 2026.
- In Q1 2026, Operating Margin fell 12198.0% year-over-year to 207.87%; the TTM figure through Mar 2026 stood at 158.91% (down 8063.0% YoY), while the FY2025 annual figure was 126.43%, down 4575.0% from the prior year.
- Operating Margin was 207.87% for Q1 2026 at Personalis, down from 145.67% in the prior quarter.
- In the past five years, Operating Margin ranged from a high of 55.94% in Q3 2024 to a low of 207.87% in Q1 2026.
- Historically, Operating Margin has averaged 139.81% across 5 years, with a median of 151.78% in 2023.
- The sharpest annual moves came in 2022 and 2024: Operating Margin sank 12608 bps in 2022, then surged 11282 bps in 2024.
- A 5-year view of Operating Margin shows it stood at 191.87% in 2022, then jumped by 36 bps to 121.84% in 2023, then rose by 12 bps to 107.81% in 2024, then tumbled by 35 bps to 145.67% in 2025, then plunged by 43 bps to 207.87% in 2026.
- The last three Operating Margin figures came in at 207.87% (Q1 2026), 145.67% (Q4 2025), and 160.68% (Q3 2025), per Business Quant data.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Waters | 29,902.70 Bn | 29,902.24 Bn | 1.11 Bn | -3.71% |
| 2 | Thermo Fisher Scientific | 175.99 Bn | 172.74 Bn | 7.74 Bn | 16.93% |
| 3 | Danaher | 129.87 Bn | 124.18 Bn | 3.59 Bn | 22.58% |
| 4 | Idexx Laboratories | 44.75 Bn | 44.55 Bn | 722.74 Mn | 31.78% |
| 5 | Agilent Technologies | 37.52 Bn | 35.72 Bn | 990.00 Mn | 21.74% |
| 6 | Iqvia Holdings | 30.91 Bn | 28.94 Bn | 1.36 Bn | 12.38% |
| 7 | Natera | 30.21 Bn | 29.11 Bn | 696.04 Mn | -13.42% |
| 8 | Illumina | 24.19 Bn | 23.04 Bn | 721.00 Mn | 19.16% |
| 9 | Mettler Toledo International | 23.12 Bn | 23.06 Bn | 555.82 Mn | 25.23% |
| 10 | Personalis | 1.05 Bn | 819.64 Mn | 281,000.00 | -207.87% |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -207.87% |
| Dec 31, 2025 | -145.67% |
| Sep 30, 2025 | -160.68% |
| Jun 30, 2025 | -126.75% |
| Mar 31, 2025 | -85.88% |
| Dec 31, 2024 | -107.81% |
| Sep 30, 2024 | -55.94% |
| Jun 30, 2024 | -74.81% |
| Mar 31, 2024 | -96.70% |
| Dec 31, 2023 | -121.84% |
| Sep 30, 2023 | -168.76% |
| Jun 30, 2023 | -151.78% |
| Mar 31, 2023 | -158.14% |
| Dec 31, 2022 | -191.87% |
| Sep 30, 2022 | -183.46% |
| Jun 30, 2022 | -152.86% |
| Mar 31, 2022 | -185.89% |
| Dec 31, 2021 | -97.79% |
| Sep 30, 2021 | -79.47% |
| Jun 30, 2021 | -68.98% |