Prime Medicine (PRME) Return on Sales [ROS] (2024 - 2026)
Prime Medicine (PRME) posted Return on Sales [ROS] of -3750.87% for Q2 2026, up 1036.31 percentage points from -4787.17% a year earlier and up 2166.66 percentage points from the prior quarter.
Prime Medicine (PRME) Return on Sales [ROS] (2024 - 2026) Analysis & Trends
For the trailing twelve months through Jun 30, 2026, Return on Sales [ROS] at Prime Medicine was -4824.94%, down 708.38 percentage points year-over-year; for FY2025, it was -4498.06%, up 2289.30 percentage points from FY2024.
- Annual Return on Sales [ROS] shows a five-year change of -4480.17 percentage points (FY2020 to FY2025).
- In prior years, Prime Medicine's Return on Sales [ROS] was -6787.36% in FY2024.
- The Q2 2026 figure stands as the highest quarterly Return on Sales [ROS] since Q1 2025.
- On a year-over-year basis, Return on Sales [ROS] increased in four of the last six quarters, with an average year-over-year change of +9016.43 percentage points.
- According to Business Quant data, Return on Sales [ROS] for the three prior quarters was -5917.52% (Q1 2026), -5800.48% (Q4 2025) and -4405.96% (Q3 2025).
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROS (Qtr) |
|---|---|---|---|---|---|
| 1 | Eli Lilly | 1,348.13 Bn | 1,321.74 Bn | 20.46 Bn | 34.46% |
| 2 | Johnson & Johnson | 675.90 Bn | 595.76 Bn | 17.30 Bn | 24.35% |
| 3 | AbbVie | 519.45 Bn | 487.50 Bn | 13.12 Bn | 36.01% |
| 4 | Merck | 364.95 Bn | 327.95 Bn | 13.19 Bn | 30.74% |
| 5 | Novartis Ag | 311.58 Bn | 285.16 Bn | - | - |
| 6 | Astrazeneca | 289.34 Bn | 262.94 Bn | 13.26 Bn | 29.12% |
| 7 | Amgen | 251.64 Bn | 203.30 Bn | 7.58 Bn | 35.79% |
| 8 | Gilead Sciences | 212.05 Bn | 187.07 Bn | 6.73 Bn | 41.71% |
| 9 | Pfizer | 167.35 Bn | 115.00 Bn | 12.56 Bn | 32.98% |
| 10 | Prime Medicine | 704.88 Mn | 469.45 Mn | - | -3,750.87% |
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -3,750.87% |
| Mar 31, 2026 | -5,917.52% |
| Sep 30, 2025 | -4,405.96% |
| Jun 30, 2025 | -4,787.17% |
| Mar 31, 2025 | -3,603.30% |
| Dec 31, 2024 | -2,025.74% |
| Sep 30, 2024 | -25,948.33% |
| Jun 30, 2024 | -37,819.80% |
| Mar 31, 2024 | -8,179.53% |
Prime Medicine Return on Sales [ROS] API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=return-on-sales-%5Bros%5D&ticker=PRME&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "return-on-sales-[ros]", "ticker": "PRME", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=return-on-sales-%5Bros%5D&ticker=PRME&period=max&api_key=YOUR_API_KEY");
const data = await res.json();