Prime Medicine (PRME) Return on Sales (2024 - 2026)
Prime Medicine's (PRME) quarterly Return on Sales came in at 2.67% in Q1 2026, down 232.0% YoY from 2.02% in Q1 2025, and down 371.1% on a QoQ basis from 0.57% in Q4 2025.
Prime Medicine (PRME) Return on Sales (2024 - 2026) Analysis & Trends
Prime Medicine (PRME) has 3 years of Return on Sales data on file, last reported at 2.67% in Q1 2026.
- Quarterly Return on Sales fell 232.0% year-over-year to 2.67% in Q1 2026, while the trailing twelve-month figure through Mar 2026 was 1.12% (down 60.0% YoY) and the FY2025 annual result came in at 0.44%, up 22.0% from the prior year.
- Return on Sales slipped to 2.67% in Q1 2026, from 0.57% in the prior quarter.
- In the past five years, Return on Sales ranged from a high of 0.19% in Q4 2024 to a low of 3.68% in Q2 2024.
- A 3-year average of 1.36% and a median of 0.77% in 2024 frame the typical range for Return on Sales.
- Annual changes were most pronounced in 2025 — Return on Sales surged 321 bps — and 2026, when it sank 232 bps.
- Tracing PRME's Return on Sales over 3 years: stood at 0.19% in 2024, then plunged by 193 bps to 0.57% in 2025, then tumbled by 371 bps to 2.67% in 2026.
- The last three Return on Sales figures came in at 2.67% (Q1 2026), 0.57% (Q4 2025), and 1.02% (Q3 2025), per Business Quant data.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROS (Qtr) |
|---|---|---|---|---|---|
| 1 | Vertex Pharmaceuticals | 128.13 Bn | 120.28 Bn | 2.84 Bn | 0.00% |
| 2 | Regeneron Pharmaceuticals | 112.33 Bn | 104.33 Bn | 3.93 Bn | 0.00% |
| 3 | Argenx Se | 53.24 Bn | 48.05 Bn | 1.41 Bn | 0.00% |
| 4 | Revolution Medicines | 43.64 Bn | 43.64 Bn | - | - |
| 5 | BeOne Medicines | 39.27 Bn | 34.17 Bn | 1.53 Bn | 0.00% |
| 6 | MindWalk Holdings | 35.32 Bn | 35.31 Bn | 1.82 Bn | 0.00% |
| 7 | Royalty Pharma | 33.72 Bn | 35.84 Bn | - | 0.00% |
| 8 | Alnylam Pharmaceuticals | 30.58 Bn | 27.27 Bn | 992.69 Mn | 0.00% |
| 9 | Insmed | 27.01 Bn | 25.85 Bn | 358.27 Mn | 0.00% |
| 10 | Prime Medicine | 558.48 Mn | 558.48 Mn | - | -1.87% |
Historic Data
Download Data| Date | Value |
|---|---|
| Jun 30, 2026 | -1.87% |
| Mar 31, 2026 | -2.67% |
| Dec 31, 2025 | -0.57% |
| Sep 30, 2025 | -1.02% |
| Jun 30, 2025 | -0.47% |
| Mar 31, 2025 | -0.36% |
| Dec 31, 2024 | -0.19% |
| Sep 30, 2024 | -2.51% |
| Jun 30, 2024 | -3.68% |
| Mar 31, 2024 | -0.77% |