Prime Medicine (PRME) Return on Sales (2024 - 2026)
Prime Medicine (PRME) posted Return on Sales of 2.67% for Q1 2026, down 371.1% on a QoQ basis from 0.57% in Q4 2025, and down 232.0% year-over-year from 2.02% in Q1 2025.
Prime Medicine (PRME) Return on Sales (2024 - 2026) Analysis & Trends
Prime Medicine's Return on Sales history runs 3 years deep, the most recent figure standing at 2.67% for Q1 2026.
- Quarterly Return on Sales fell 232.0% year-over-year to 2.67% in Q1 2026, while the trailing twelve-month figure through Mar 2026 was 1.12% (down 60.0% YoY) and the FY2025 annual result came in at 0.44%, up 22.0% from the prior year.
- Return on Sales was 2.67% for Q1 2026 at Prime Medicine, down from 0.57% in the prior quarter.
- Across five years, Return on Sales topped out at 0.19% in Q4 2024 and bottomed at 3.68% in Q2 2024.
- A 3-year average of 1.36% and a median of 0.77% in 2024 frame the typical range for Return on Sales.
- Annual changes were most pronounced in 2025 — Return on Sales surged 321 bps — and 2026, when it plunged 232 bps.
- Prime Medicine's Return on Sales stood at 0.19% in 2024, then slumped by 193 bps to 0.57% in 2025, then sank by 371 bps to 2.67% in 2026.
- Business Quant data shows PRME's Return on Sales at 2.67% in Q1 2026, 0.57% in Q4 2025, and 1.02% in Q3 2025.
Powered by 
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROS (Qtr) |
|---|---|---|---|---|---|
| 1 | Oculis Holding AG | 68,785.72 Bn | 68,785.72 Bn | - | - |
| 2 | Nanobiotix | 1,895.57 Bn | 1,895.51 Bn | - | - |
| 3 | BeOne Medicines | 471.35 Bn | 466.56 Bn | 1.35 Bn | 0.00% |
| 4 | NuCana | 279.75 Bn | 279.75 Bn | - | - |
| 5 | Vertex Pharmaceuticals | 120.24 Bn | 113.00 Bn | 2.59 Bn | 0.00% |
| 6 | Regeneron Pharmaceuticals | 67.80 Bn | 59.04 Bn | 3.31 Bn | 0.00% |
| 7 | Belite Bio | 62.51 Bn | 62.51 Bn | - | - |
| 8 | Argenx Se | 57.38 Bn | 57.38 Bn | 1.41 Bn | 0.00% |
| 9 | Revolution Medicines | 37.78 Bn | 37.78 Bn | - | - |
| 10 | Prime Medicine | 525.98 Mn | 525.98 Mn | - | -2.67% |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -2.67% |
| Dec 31, 2025 | -0.57% |
| Sep 30, 2025 | -1.02% |
| Jun 30, 2025 | -0.47% |
| Mar 31, 2025 | -0.36% |
| Dec 31, 2024 | -0.19% |
| Sep 30, 2024 | -2.51% |
| Jun 30, 2024 | -3.68% |
| Mar 31, 2024 | -0.77% |