Prime Medicine (PRME) Return on Sales (2024 - 2026)
Prime Medicine posted quarterly Return on Sales of 0.58% for Q1 2026, down 22.0% year-on-year from 0.74% in Q1 2025, and down 2.24% on a QoQ basis from 0.57% in Q4 2025.
Prime Medicine (PRME) has 3 years of Return on Sales data on file, last reported at 0.58% in Q1 2026.
- For the quarter ending Q1 2026, Return on Sales fell 22.0% year-over-year to 0.58%; the trailing twelve-month figure through Mar 2026 stood at 0.5% (up 2.0% YoY), and the FY2025 full-year result was 0.44%, up 22.0% from the prior year.
- Return on Sales for Q1 2026 stood at 0.58%, down from 0.57% in the prior quarter.
- Across five years, Return on Sales topped out at 0.19% in Q4 2024 and bottomed at 3.68% in Q2 2024.
- The 3-year median for Return on Sales is 0.57% (2025), against an average of 1.06%.
- Peak annual rise in Return on Sales reached 321 bps in 2025, while the deepest fall reached 37 bps in 2025.
- A 3-year view of Return on Sales shows it stood at 0.19% in 2024, then plunged by 193 bps to 0.57% in 2025, then fell by 2 bps to 0.58% in 2026.
- The last three Return on Sales figures came in at 0.58% (Q1 2026), 0.57% (Q4 2025), and 0.43% (Q3 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROS (Qtr) |
|---|---|---|---|---|---|
| 1 | Quantum Biopharma | 961,148.99 Bn | 961,148.98 Bn | - | - |
| 2 | Alterity Therapeutics | 744,933.29 Bn | 744,933.26 Bn | - | - |
| 3 | Legend Biotech | 2,540.00 Bn | 2,539.71 Bn | 242.10 Mn | 0.00% |
| 4 | Nanobiotix | 2,199.85 Bn | 2,199.78 Bn | - | - |
| 5 | Akari Therapeutics | 1,635.88 Bn | 1,635.88 Bn | - | - |
| 6 | Vertex Pharmaceuticals | 111.32 Bn | 104.07 Bn | 2.59 Bn | 0.00% |
| 7 | Evaxion A | 62.56 Bn | 62.54 Bn | - | 0.00% |
| 8 | Regeneron Pharmaceuticals | 62.55 Bn | 53.79 Bn | 3.31 Bn | 0.00% |
| 9 | Alnylam Pharmaceuticals | 39.57 Bn | 36.56 Bn | 959.66 Mn | 0.00% |
| 10 | Prime Medicine | 601.24 Mn | 601.24 Mn | - | -0.58% |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -0.58% |
| Dec 31, 2025 | -0.57% |
| Sep 30, 2025 | -0.43% |
| Jun 30, 2025 | -0.47% |
| Mar 31, 2025 | -0.36% |
| Dec 31, 2024 | -0.19% |
| Sep 30, 2024 | -2.51% |
| Jun 30, 2024 | -3.68% |
| Mar 31, 2024 | -0.77% |