Prime Medicine, Inc. (PRME) Institutional Ownership

Institutions by Trading Activity

158,068,750Shares Outstanding

1,115Shares held by institutions

$4,371Value of institutional holdings

0.12%Institutional ownership %

0.33%Shares Changed QoQ

4No. of institutional investors

According to SEC filings for the period ending December 2025, Prime Medicine, Inc. (NASDAQ:PRME) is held by 4 institutional firms.

The collective stake of institutional investors in Prime Medicine moved to 0.1% in December 2025, a shift down from the 58.6% reported for September 2025.
Quarterly data indicates a 0.33% shift in institutional share volume, and the annual owner count reflects a decrease of 96.85%.
A review of institutional activity for Prime Medicine shows 2 of 4 filers increasing their positions, while 0 reduced their stake, and 2 remained unchanged.
Collectively, institutional investors increased their stake in Prime Medicine to 192.11K shares as of December 2025, a change that is up by 641 shares quarter on quarter and down 63.66Mn shares year over year.
With 190.88K shares, Green Alpha Advisors, LLC commands the largest institutional position in Prime Medicine as of December 31, 2025, equating to 0.12% of the company.
Among the most significant buyers of Prime Medicine during December 2025 were Green Alpha Advisors, LLC (530), GAMMA Investing LLC (111).
The top 4 institutional holders of Prime Medicine for the quarter ending December 2025 included Green Alpha Advisors, LLC (190.88K), Corsicana & Co. (1.00K), True Wealth Design, LLC (115), GAMMA Investing LLC (111).

1,115 Total Shares Held

Rows:

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
Alphabet Inc.	30 Sep, 2025	16,562,498	1,500,000	9.96%	$91,756,239.00
T. Rowe Price Investment Management, Inc.	30 Sep, 2025	9,217,097	2,732,310	42.13%	$51,063.00
BlackRock, Inc.	30 Sep, 2025	5,650,859	1,165,031	25.97%	$31,305,758.00
ARK Investment Management LLC	30 Sep, 2025	5,477,851	3,155,182	135.84%	$30,347,295.00
VANGUARD GROUP INC	30 Sep, 2025	4,921,865	1,294,355	35.68%	$27,267,132.00
FARALLON CAPITAL MANAGEMENT LLC	30 Sep, 2025	4,750,000	4,000,000	533.33%	$26,315,000.00
Sumitomo Mitsui Trust Group, Inc.	30 Sep, 2025	3,629,924	2,035,406	127.65%	$20,109,779.00
Amova Asset Management Americas, Inc.	30 Sep, 2025	3,629,924	2,040,807	128.42%	$20,037,180.00
Casdin Capital, LLC	30 Sep, 2025	3,167,175	1,600,000	102.09%	$17,546,150.00
Woodline Partners LP	30 Sep, 2025	3,002,482	3,002,482	0.00%	$16,633,750.00
RA CAPITAL MANAGEMENT, L.P.	30 Sep, 2025	3,000,000	3,000,000	0.00%	$16,620,000.00
FMR LLC	30 Sep, 2025	2,813,075	-931,352	-24.87%	$15,584,435.00
D. E. Shaw & Co., Inc.	30 Sep, 2025	2,215,852	2,215,852	0.00%	$12,275,820.00
MWG Management Ltd.	30 Sep, 2025	1,792,210	0	0.00%	$9,928,843.00
GEODE CAPITAL MANAGEMENT, LLC	30 Sep, 2025	1,766,896	256,147	16.95%	$9,790,782.00
EcoR1 Capital, LLC	30 Sep, 2025	1,543,326	1,543,326	0.00%	$8,550,026.00
MILLENNIUM MANAGEMENT LLC	30 Sep, 2025	1,418,463	1,270,467	858.45%	$7,858,285.00
STATE STREET CORP	30 Sep, 2025	1,296,626	57,289	4.62%	$7,183,308.00
RENAISSANCE TECHNOLOGIES LLC	30 Sep, 2025	1,134,670	911,270	407.91%	$6,286,072.00
CITADEL ADVISORS LLC	30 Sep, 2025	900,142	900,142	0.00%	$4,986,786.00

1 - 20 of 165