Prime Medicine, Inc. (PRME) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

158,068,750Shares Outstanding

20,913,022Shares held by institutions

$69,222,103Value of institutional holdings

57.90%Institutional ownership %

11.55%Shares Changed QoQ

170No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

According to SEC filings for the period ending December 2025, Prime Medicine, Inc. (NASDAQ:PRME) is held by 170 institutional firms.

Prime Medicine saw its institutional ownership percentage fell to 57.9% in December 2025 from 58.6% in September 2025.
In percentage terms, this reflects as a holdings change of 11.55% quarter on quarter, and an increase of 33.86% year over year.
Among the 170 institutional holders of Prime Medicine, 103 added to their stakes while 38 trimmed their positions and 29 held steady.
This class of investors increased its holdings in Prime Medicine to 91.53Mn shares for the 13F-cycle ending December 2025, up by 9.48Mn shares quarter on quarter, and up 27.68Mn shares year over year.
As of December 31, 2025, Alphabet Inc. held Prime Medicine's largest shareholding position with over 16.56Mn shares, representing 10.48% of total outstanding shares.
Among the most significant buyers of Prime Medicine during December 2025 were STATE STREET CORP (3.80Mn), BALYASNY ASSET MANAGEMENT L.P. (3.08Mn), BlackRock, Inc. (2.62Mn), UBS Group AG (2.14Mn), MWG Caph Ltd (1.79Mn).
Leading sellers of Prime Medicine stock in December 2025 included T. Rowe Price Investment Management, Inc. (8.12Mn), FARALLON CAPITAL MANAGEMENT LLC (3.51Mn), MILLENNIUM MANAGEMENT LLC (1.37Mn), CITADEL ADVISORS LLC (787.27K), D. E. Shaw & Co., Inc. (664.48K).
The top 10 institutional holders of Prime Medicine for the quarter ending December 2025 included Alphabet Inc. (16.56Mn), BlackRock, Inc. (8.27Mn), VANGUARD GROUP INC (6.47Mn), ARK Investment Management LLC (5.37Mn), STATE STREET CORP (5.10Mn), Amova Asset Management Americas, Inc. (3.25Mn), Sumitomo Mitsui Trust Group, Inc. (3.25Mn), Casdin Capital, LLC (3.17Mn), BALYASNY ASSET MANAGEMENT L.P. (3.12Mn), Woodline Partners LP (3.00Mn).

170 Institutional Holders

20,913,022 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
Alphabet Inc.	31 Dec, 2025	16,562,498	0	0.00%	$57,471,868.00
BlackRock, Inc.	31 Dec, 2025	8,268,843	2,617,984	46.33%	$28,692,886.00
VANGUARD GROUP INC	31 Dec, 2025	6,467,872	1,546,007	31.41%	$22,443,516.00
ARK Investment Management LLC	31 Dec, 2025	5,368,526	-109,325	-2.00%	$18,628,784.00
STATE STREET CORP	31 Dec, 2025	5,095,510	3,798,884	292.98%	$17,681,420.00
Amova Asset Management Americas, Inc.	31 Dec, 2025	3,245,506	-384,418	-10.59%	$11,196,996.00
Sumitomo Mitsui Trust Group, Inc.	31 Dec, 2025	3,245,506	-384,418	-10.59%	$11,261,906.00
Casdin Capital, LLC	31 Dec, 2025	3,167,175	0	0.00%	$10,990,097.00
BALYASNY ASSET MANAGEMENT L.P.	31 Dec, 2025	3,124,362	3,076,489	6,426.36%	$10,841,536.00
Woodline Partners LP	31 Dec, 2025	3,002,844	362	0.01%	$10,419,869.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	2,628,429	861,533	48.76%	$9,123,032.00
UBS Group AG	31 Dec, 2025	2,440,583	2,135,810	700.79%	$8,468,823.00
FMR LLC	31 Dec, 2025	2,176,646	-636,429	-22.62%	$7,552,961.00
MWG Caph Ltd	31 Dec, 2025	1,792,210	1,792,210	0.00%	$6,218,969.00
GOLDMAN SACHS GROUP INC	31 Dec, 2025	1,755,768	1,345,032	327.47%	$6,092,515.00
TWO SIGMA INVESTMENTS, LP	31 Dec, 2025	1,629,324	1,181,657	263.96%	$5,653,754.00
D. E. Shaw & Co., Inc.	31 Dec, 2025	1,551,369	-664,483	-29.99%	$5,383,250.00
FARALLON CAPITAL MANAGEMENT LLC	31 Dec, 2025	1,240,843	-3,509,157	-73.88%	$4,305,725.00
SUSQUEHANNA INTERNATIONAL GROUP, LLP	31 Dec, 2025	1,176,727	592,303	101.35%	$4,083,243.00
MORGAN STANLEY	31 Dec, 2025	1,169,898	438,894	60.04%	$4,059,547.00

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