Prime Medicine, Inc. (PRME) Insider Ownership

Historic Insider Ownership Trends

As of March 23, 2026, the three largest insider holders of PRME are David R. Liu (TenPercentOwner, 20.24Mn shares), Venture Partners Xii, Llc Arch (TenPercentOwner, 6.23Mn shares), Venture Partners X, Llc Arch (TenPercentOwner, 6.23Mn shares).

Top Direct Holders

Insider ownership data is derived from the last 60 months of Form 4 SEC filings.
Holder Position Shares (Direct) Shares (Indirect) Report Date
David R. Liu 20,240,945 0 01 Jul, 2025
Venture Partners Xii, Llc Arch 0 6,230,300 01 Aug, 2025
Venture Partners X, Llc Arch 0 6,230,300 01 Aug, 2025
Thomas Cahill 0 5,305,679 26 Oct, 2022
2021 Gp, L.L.C. Gv 0 3,262,440 05 Aug, 2025
2021 Gp, L.L.C. Gv 0 3,262,440 05 Aug, 2025
Keith Michael Gottesdiener See Remarks 2,310,837 0 07 Jun, 2024
Keith Michael Gottesdiener See Remarks 0 682,259 10 Oct, 2024
Allan Reine Chief Executive Officer 125,000 0 22 May, 2025
Ann L. Lee Chief Technical Officer 100,000 0 22 May, 2025
Richard Brudnick Chief Business Officer 20,000 0 22 May, 2025

* Please note that the shares above only reflect shares from the fund portfolio and the institutional portfolio. Shares from the personal portfolio are excluded from this Institutional Ownership Page. See these insiders' latest transactions here on Insider Page.

Recent Insider Transactions

Detailed insider trading activity based on Form 4 SEC filings.
Download Data
Transaction Date Insider Name Security Class Transaction Type Shares Traded Price Shares Remaining Ownership Code
26 Feb, 2026 Allan Reine Stock Option (right to buy) A 1,300,000 $0.00 1,300,000 D A
23 Feb, 2026 Ann L. Lee Stock Option (right to buy) A 375,000 $0.00 375,000 D A
23 Feb, 2026 Carman Alenson Stock Option (right to buy) A 140,000 $0.00 140,000 D A
01 Aug, 2025 Thomas Cahill Stock Option (right to buy) D 39,062 - 0 D D
01 Aug, 2025 Allan Reine Stock Option (right to buy) D 850,000 - 0 D D
01 Aug, 2025 Jeffrey D Marrazzo Stock Option (right to buy) D 92,000 - 0 D D
01 Aug, 2025 Ann L. Lee Stock Option (right to buy) D 180,995 - 0 D D
01 Aug, 2025 David P Schenkein Stock Option (right to buy) D 39,062 - 0 D D
01 Aug, 2025 Michael Aaron Kelly Stock Option (right to buy) D 13,510 - 0 D D
01 Aug, 2025 Carman Alenson Stock Option (right to buy) D 16,083 - 0 D D
01 Aug, 2025 2021 Gp, L.L.C. Gv Common Stock A 1,500,000 $3.30 3,262,440 I P
01 Aug, 2025 Wendy Chung Stock Option (right to buy) D 13,510 - 0 D D
01 Aug, 2025 2021 Gp, L.L.C. Gv Common Stock A 1,500,000 $3.30 3,262,440 I P
01 Aug, 2025 Jeffrey D Marrazzo Stock Option (right to buy) A 92,000 - 92,000 D A
01 Aug, 2025 David P Schenkein Stock Option (right to buy) A 39,062 - 39,062 D A
01 Aug, 2025 Allan Reine Stock Option (right to buy) A 850,000 - 850,000 D A
01 Aug, 2025 Michael Aaron Kelly Stock Option (right to buy) A 13,510 - 13,510 D A
01 Aug, 2025 Ann L. Lee Stock Option (right to buy) A 180,995 - 180,995 D A
01 Aug, 2025 Wendy Chung Stock Option (right to buy) A 13,510 - 13,510 D A
01 Aug, 2025 Thomas Cahill Stock Option (right to buy) A 39,062 - 39,062 D A