Prime Medicine (PRME) Return on Equity [ROE] (2022 - 2026)
Prime Medicine's Return on Equity [ROE] came in at -330.42% for Q2 2026, down 92.89 percentage points from -237.54% a year earlier and down 125.35 percentage points from the prior quarter.
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Analysis
Prime Medicine (PRME) Return on Equity [ROE] (2022 - 2026) Analysis & Trends
For FY2025, Prime Medicine's Return on Equity [ROE] was -149.04%, down 12.17 percentage points from FY2024.
- Return on Equity [ROE] carries a three-year change of +3.21 percentage points (FY2022 to FY2025).
- Going back by year, Return on Equity [ROE] was -136.88% in FY2024 (-48.69 pp), -88.19% in FY2023 (+64.06 pp) and -152.25% in FY2022.
- The Q2 2026 figure represents the lowest quarterly Return on Equity [ROE] in data going back to Q4 2022.
- Year-over-year, Return on Equity [ROE] has declined for six consecutive quarters, with an average year-over-year change of -56.51 percentage points over the last eight quarters.
- The fastest year-over-year change in Return on Equity [ROE] over five years came in Q4 2023 (a gain of 140.32 percentage points), and the weakest in Q2 2025 (a drop of 138.78 percentage points).
- Business Quant data shows PRME's Return on Equity [ROE] at -205.07% (Q1 2026), -144.92% (Q4 2025) and -179.26% (Q3 2025) in the three quarters before Q2 2026.
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROE (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 638.12 Bn | 556.64 Bn | 17.26 Bn | 25.32% |
| 2 | AbbVie | 462.60 Bn | 435.75 Bn | 12.70 Bn | - |
| 3 | Merck | 358.70 Bn | 313.13 Bn | 12.21 Bn | 7.21% |
| 4 | Novartis Ag | 272.16 Bn | 228.03 Bn | 11.24 Bn | 84.40% |
| 5 | Astrazeneca | 250.36 Bn | 223.92 Bn | 12.86 Bn | 21.39% |
| 6 | Amgen | 227.87 Bn | 183.27 Bn | 7.24 Bn | 83.75% |
| 7 | Gilead Sciences | 184.97 Bn | 159.08 Bn | 6.22 Bn | -18.38% |
| 8 | Pfizer | 162.61 Bn | 109.56 Bn | 10.94 Bn | 4.97% |
| 9 | Vertex Pharmaceuticals | 132.45 Bn | 104.46 Bn | 2.84 Bn | 22.24% |
| 10 | Prime Medicine | 553.06 Mn | 553.06 Mn | - | -330.42% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -330.42% |
| Mar 31, 2026 | -205.07% |
| Dec 31, 2025 | -144.92% |
| Sep 30, 2025 | -179.26% |
| Jun 30, 2025 | -237.54% |
| Mar 31, 2025 | -155.35% |
| Dec 31, 2024 | -114.33% |
| Sep 30, 2024 | -113.57% |
| Jun 30, 2024 | -98.76% |
| Mar 31, 2024 | -108.53% |
| Dec 31, 2023 | -121.17% |
| Sep 30, 2023 | -79.15% |
| Jun 30, 2023 | -57.97% |
| Mar 31, 2023 | -46.17% |
| Dec 31, 2022 | -261.49% |
API Access
Prime Medicine Return on Equity [ROE] API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=return-on-equity-%5Broe%5D&ticker=PRME&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "return-on-equity-[roe]", "ticker": "PRME", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=return-on-equity-%5Broe%5D&ticker=PRME&period=max&api_key=YOUR_API_KEY");
const data = await res.json();