Prime Medicine (PRME) Return on Capital Employed [ROCE] (2022 - 2026)
Prime Medicine (PRME) posted Return on Capital Employed [ROCE] of -81.82% for Q2 2026, down 6.03 percentage points from -75.78% a year earlier and down 8.67 percentage points from the prior quarter.
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Analysis
Prime Medicine (PRME) Return on Capital Employed [ROCE] (2022 - 2026) Analysis & Trends
For FY2025, Prime Medicine's Return on Capital Employed [ROCE] came in at -73.71%, up 23.76 percentage points from FY2024.
- Annual Return on Capital Employed [ROCE] shows a three-year change of -35.42 percentage points (FY2022 to FY2025).
- In prior years, Prime Medicine's Return on Capital Employed [ROCE] was -97.47% in FY2024 (-4.66 pp), -92.81% in FY2023 (-54.52 pp) and -38.29% in FY2022.
- The Q2 2026 figure stands as the lowest quarterly Return on Capital Employed [ROCE] since Q3 2024.
- On a year-over-year basis, Return on Capital Employed [ROCE] increased in six of the last eight quarters, with an average year-over-year change of +12.22 percentage points.
- The strongest year-over-year quarter for Return on Capital Employed [ROCE] in the past five years was Q4 2024, with a gain of 54.89 percentage points; the weakest was Q4 2023, with a drop of 83.30 percentage points.
- According to Business Quant data, Return on Capital Employed [ROCE] for the three prior quarters was -73.15% (Q1 2026), -63.83% (Q4 2025) and -68.68% (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROCE (Qtr) |
|---|---|---|---|---|---|
| 1 | Eli Lilly | 1,076.25 Bn | 1,044.84 Bn | 19.71 Bn | 46.74% |
| 2 | Johnson & Johnson | 617.18 Bn | 535.70 Bn | 17.26 Bn | 17.83% |
| 3 | AbbVie | 464.58 Bn | 437.73 Bn | 12.70 Bn | 17.92% |
| 4 | Merck | 356.04 Bn | 310.47 Bn | 12.21 Bn | 6.28% |
| 5 | Novartis Ag | 269.07 Bn | 224.94 Bn | 11.24 Bn | 19.32% |
| 6 | Astrazeneca | 243.21 Bn | 216.77 Bn | 12.86 Bn | 9.54% |
| 7 | Amgen | 217.88 Bn | 173.28 Bn | 7.24 Bn | 16.66% |
| 8 | Gilead Sciences | 179.62 Bn | 153.74 Bn | 6.22 Bn | -5.97% |
| 9 | Pfizer | 158.45 Bn | 105.40 Bn | 10.94 Bn | 11.86% |
| 10 | Prime Medicine | 538.60 Mn | 538.60 Mn | - | -81.82% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -81.82% |
| Mar 31, 2026 | -73.15% |
| Dec 31, 2025 | -63.83% |
| Sep 30, 2025 | -68.68% |
| Jun 30, 2025 | -75.78% |
| Mar 31, 2025 | -74.14% |
| Dec 31, 2024 | -73.04% |
| Sep 30, 2024 | -87.58% |
| Jun 30, 2024 | -84.41% |
| Mar 31, 2024 | -93.39% |
| Dec 31, 2023 | -127.94% |
| Sep 30, 2023 | -79.51% |
| Jun 30, 2023 | -57.60% |
| Mar 31, 2023 | -43.42% |
| Dec 31, 2022 | -44.64% |
API Access
Prime Medicine Return on Capital Employed [ROCE] API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=return-on-capital-employed-%5Broce%5D&ticker=PRME&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "return-on-capital-employed-[roce]", "ticker": "PRME", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=return-on-capital-employed-%5Broce%5D&ticker=PRME&period=max&api_key=YOUR_API_KEY");
const data = await res.json();