Prime Medicine (PRME) Net Margin (2024 - 2026)
Prime Medicine (PRME) reported Net Margin of -3648.96% for Q2 2026, up 1067.72 percentage points from -4716.68% a year earlier and up 2089.59 percentage points from the prior quarter.
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Analysis
Prime Medicine (PRME) Net Margin (2024 - 2026) Analysis & Trends
Over the twelve months ended Jun 30, 2026, Prime Medicine's Net Margin came in at -4613.11%, down 596.28 percentage points year-over-year; for FY2025, it was -4342.44%, up 2224.17 percentage points from FY2024.
- Net Margin has a five-year change of -4245.42 percentage points (FY2020 to FY2025).
- By year, Net Margin came in at -6566.61% in FY2024.
- The Q2 2026 figure ranks as the highest quarterly Net Margin since Q1 2025.
- Year over year, Net Margin gained in three of the last five quarters, with an average year-over-year change of +4101.83 percentage points.
- Per Business Quant data, the three quarters before Q2 2026 came in at -5738.55% (Q1 2026), -5498.69% (Q4 2025) and -4129.14% (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Net Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 655.56 Bn | 574.09 Bn | 17.26 Bn | 21.86% |
| 2 | AbbVie | 470.94 Bn | 444.10 Bn | 12.70 Bn | 21.27% |
| 3 | Merck | 367.14 Bn | 321.57 Bn | 12.21 Bn | -8.04% |
| 4 | Novartis Ag | 280.33 Bn | 236.20 Bn | 11.24 Bn | 22.61% |
| 5 | Astrazeneca | 257.78 Bn | 231.34 Bn | 12.86 Bn | 18.81% |
| 6 | Amgen | 226.04 Bn | 181.44 Bn | 7.24 Bn | 23.62% |
| 7 | Gilead Sciences | 188.89 Bn | 163.01 Bn | 6.22 Bn | -134.51% |
| 8 | Pfizer | 163.75 Bn | 110.70 Bn | 10.94 Bn | -1.65% |
| 9 | Vertex Pharmaceuticals | 133.68 Bn | 105.69 Bn | 2.84 Bn | 32.99% |
| 10 | Prime Medicine | 520.52 Mn | 520.52 Mn | - | -3,648.96% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -3,648.96% |
| Mar 31, 2026 | -5,738.55% |
| Dec 31, 2025 | -5,498.69% |
| Sep 30, 2025 | -4,129.14% |
| Jun 30, 2025 | -4,716.68% |
| Mar 31, 2025 | -3,568.78% |
| Dec 31, 2024 | -1,936.60% |
| Sep 30, 2024 | -25,128.23% |
| Mar 31, 2024 | -7,742.98% |
API Access
Prime Medicine Net Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=net-margin&ticker=PRME&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "net-margin", "ticker": "PRME", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=net-margin&ticker=PRME&period=max&api_key=YOUR_API_KEY");
const data = await res.json();