Prime Medicine (PRME) Net Margin (2024 - 2026)
Prime Medicine's (PRME) quarterly Net Margin came in at 5738.55% in Q1 2026, down 216978.0% YoY from N/an in Q1 2025, and down 4.36% on a QoQ basis from 5498.69% in Q4 2025.
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Prime Medicine (PRME) Net Margin (2024 - 2026) Analysis & Trends
Prime Medicine (PRME) has 3 years of Net Margin data on file, last reported at 5738.55% in Q1 2026.
- Quarterly Net Margin fell 216978.0% year-over-year to 5738.55% in Q1 2026, while the trailing twelve-month figure through Mar 2026 was 4917.55% (up 33495.0% YoY) and the FY2025 annual result came in at 4342.44%, up 222417.0% from the prior year.
- Net Margin declined to 5738.55% in Q1 2026, from 5498.69% in the prior quarter.
- In the past five years, Net Margin ranged from a high of 1936.6% in Q4 2024 to a low of 25128.23% in Q3 2024.
- A 3-year average of 7307.46% and a median of 5107.68% in 2025 frame the typical range for Net Margin.
- The widest YoY moves for Net Margin: up 2099909 bps in 2025, down 356209 bps in 2025.
- Tracing PRME's Net Margin over 3 years: stood at 1936.6% in 2024, then sank by 184 bps to 5498.69% in 2025, then dropped by 4 bps to 5738.55% in 2026.
- The last three Net Margin figures came in at 5738.55% (Q1 2026), 5498.69% (Q4 2025), and 4129.14% (Q3 2025), per Business Quant data.
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Net Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Vertex Pharmaceuticals | 138.47 Bn | 130.62 Bn | 2.84 Bn | 32.99% |
| 2 | Regeneron Pharmaceuticals | 85.18 Bn | 77.19 Bn | 3.93 Bn | 30.23% |
| 3 | Argenx Se | 63.38 Bn | 58.19 Bn | 1.37 Bn | 31.16% |
| 4 | Moderna | 58.09 Bn | 52.95 Bn | 52.00 Mn | -539.31% |
| 5 | Revolution Medicines | 44.33 Bn | 44.33 Bn | - | - |
| 6 | BeOne Medicines | 40.02 Bn | 34.92 Bn | 1.53 Bn | 13.90% |
| 7 | Alnylam Pharmaceuticals | 35.57 Bn | 32.27 Bn | 992.69 Mn | 12.74% |
| 8 | Royalty Pharma | 28.45 Bn | 27.61 Bn | - | 12.09% |
| 9 | Insmed | 27.48 Bn | 26.32 Bn | 358.27 Mn | -3.12% |
| 10 | Prime Medicine | 653.96 Mn | 653.96 Mn | - | -3,648.96% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -3,648.96% |
| Mar 31, 2026 | -5,738.55% |
| Dec 31, 2025 | -5,498.69% |
| Sep 30, 2025 | -4,129.14% |
| Jun 30, 2025 | -4,716.68% |
| Mar 31, 2025 | -3,568.78% |
| Dec 31, 2024 | -1,936.60% |
| Sep 30, 2024 | -25,128.23% |
| Mar 31, 2024 | -7,742.98% |