Prime Medicine (PRME) Net Margin (2024 - 2026)
Prime Medicine (PRME) posted Net Margin of 5738.55% for Q1 2026, down 4.36% on a QoQ basis from 5498.69% in Q4 2025, and down 216978.0% year-over-year from N/an in Q1 2025.
Prime Medicine (PRME) Net Margin (2024 - 2026) Analysis & Trends
Prime Medicine's Net Margin history runs 3 years deep, the most recent figure standing at 5738.55% for Q1 2026.
- Quarterly Net Margin fell 216978.0% year-over-year to 5738.55% in Q1 2026, while the trailing twelve-month figure through Mar 2026 was 4917.55% (up 33495.0% YoY) and the FY2025 annual result came in at 4342.44%, up 222417.0% from the prior year.
- Net Margin was 5738.55% for Q1 2026 at Prime Medicine, down from 5498.69% in the prior quarter.
- Across five years, Net Margin topped out at 1936.6% in Q4 2024 and bottomed at 25128.23% in Q3 2024.
- A 3-year average of 7307.46% and a median of 5107.68% in 2025 frame the typical range for Net Margin.
- Peak annual rise in Net Margin reached 2099909 bps in 2025, while the deepest fall reached 356209 bps in 2025.
- Prime Medicine's Net Margin stood at 1936.6% in 2024, then tumbled by 184 bps to 5498.69% in 2025, then fell by 4 bps to 5738.55% in 2026.
- Business Quant data shows PRME's Net Margin at 5738.55% in Q1 2026, 5498.69% in Q4 2025, and 4129.14% in Q3 2025.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Net Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Oculis Holding AG | 68,785.72 Bn | 68,785.72 Bn | - | - |
| 2 | Nanobiotix | 1,895.57 Bn | 1,895.51 Bn | - | - |
| 3 | BeOne Medicines | 471.35 Bn | 466.56 Bn | 1.35 Bn | 15.02% |
| 4 | NuCana | 279.75 Bn | 279.75 Bn | - | - |
| 5 | Vertex Pharmaceuticals | 120.24 Bn | 113.00 Bn | 2.59 Bn | 34.53% |
| 6 | Regeneron Pharmaceuticals | 67.80 Bn | 59.04 Bn | 3.31 Bn | 20.17% |
| 7 | Belite Bio | 62.51 Bn | 62.51 Bn | - | - |
| 8 | Argenx Se | 57.38 Bn | 57.38 Bn | 1.41 Bn | 30.33% |
| 9 | Revolution Medicines | 37.78 Bn | 37.78 Bn | - | - |
| 10 | Prime Medicine | 525.98 Mn | 525.98 Mn | - | -5,738.55% |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -5,738.55% |
| Dec 31, 2025 | -5,498.69% |
| Sep 30, 2025 | -4,129.14% |
| Jun 30, 2025 | -4,716.68% |
| Mar 31, 2025 | -3,568.78% |
| Dec 31, 2024 | -1,936.60% |
| Sep 30, 2024 | -25,128.23% |
| Mar 31, 2024 | -7,742.98% |