Prime Medicine (PRME) Net Margin (2024 - 2026)

Prime Medicine posted quarterly Net Margin of 5738.55% for Q1 2026, down 216978.0% year-on-year from N/an in Q1 2025, and down 4.36% on a QoQ basis from 5498.69% in Q4 2025.

Prime Medicine (PRME) has 3 years of Net Margin data on file, last reported at 5738.55% in Q1 2026.

  • For the quarter ending Q1 2026, Net Margin fell 216978.0% year-over-year to 5738.55%; the trailing twelve-month figure through Mar 2026 stood at 4917.55% (up 33495.0% YoY), and the FY2025 full-year result was 4342.44%, up 222417.0% from the prior year.
  • Net Margin for Q1 2026 stood at 5738.55%, down from 5498.69% in the prior quarter.
  • Across five years, Net Margin topped out at 1936.6% in Q4 2024 and bottomed at 25128.23% in Q3 2024.
  • The 3-year median for Net Margin is 5107.68% (2025), against an average of 7307.46%.
  • Peak annual rise in Net Margin reached 2099909 bps in 2025, while the deepest fall reached 356209 bps in 2025.
  • A 3-year view of Net Margin shows it stood at 1936.6% in 2024, then plunged by 184 bps to 5498.69% in 2025, then declined by 4 bps to 5738.55% in 2026.
  • The last three Net Margin figures came in at 5738.55% (Q1 2026), 5498.69% (Q4 2025), and 4129.14% (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Net Margin (Qtr)
1 Quantum Biopharma 961,148.99 Bn 961,148.98 Bn - -
2 Alterity Therapeutics 744,933.29 Bn 744,933.26 Bn - -
3 Legend Biotech 2,540.00 Bn 2,539.71 Bn 242.10 Mn 0.82%
4 Nanobiotix 2,199.85 Bn 2,199.78 Bn - -
5 Akari Therapeutics 1,635.88 Bn 1,635.88 Bn - -
6 Vertex Pharmaceuticals 111.32 Bn 104.07 Bn 2.59 Bn 34.53%
7 Evaxion A 62.56 Bn 62.54 Bn - -
8 Regeneron Pharmaceuticals 62.55 Bn 53.79 Bn 3.31 Bn 20.17%
9 Alnylam Pharmaceuticals 39.57 Bn 36.56 Bn 959.66 Mn 17.65%
10 Prime Medicine 601.24 Mn 601.24 Mn - -5,738.55%

Historic Data

Download Data 🔒
DateValue
Mar 31, 2026 -5,738.55%
Dec 31, 2025 -5,498.69%
Sep 30, 2025 -4,129.14%
Jun 30, 2025 -4,716.68%
Mar 31, 2025 -3,568.78%
Dec 31, 2024 -1,936.60%
Sep 30, 2024 -25,128.23%
Mar 31, 2024 -7,742.98%