Prime Medicine (PRME) Net Cash Flow (2021 - 2026)

Prime Medicine posted quarterly Net Cash Flow of $1.1 million for Q1 2026, up 101.19% year-on-year from $533835.8 in Q1 2025, and up 112.84% on a QoQ basis from -$8.4 million in Q4 2025.

Prime Medicine (PRME) has 6 years of Net Cash Flow data on file, last reported at $1.1 million in Q1 2026.

  • For the quarter ending Q1 2026, Net Cash Flow rose 101.19% year-over-year to $1.1 million; the trailing twelve-month figure through Mar 2026 stood at -$28.1 million (down 1537.11% YoY), and the FY2025 full-year result was -$119.8 million, down 184.69% from the prior year.
  • Net Cash Flow for Q1 2026 stood at $1.1 million, up from -$8.4 million in the prior quarter.
  • Across five years, Net Cash Flow topped out at $139.7 million in Q4 2022 and bottomed at -$90.6 million in Q1 2025.
  • The 5-year median for Net Cash Flow is -$12.9 million (2023), against an average of -$7.1 million.
  • The widest annual swing landed in 2022, when Net Cash Flow soared 6691.46%; it then tumbled 272.28% in 2025.
  • A 5-year view of Net Cash Flow shows it stood at $139.7 million in 2022, then plunged by 101.71% to -$2.4 million in 2023, then surged by 2804.36% to $64.5 million in 2024, then tumbled by 112.97% to -$8.4 million in 2025, then jumped by 112.84% to $1.1 million in 2026.
  • The last three Net Cash Flow figures came in at $1.1 million (Q1 2026), -$8.4 million (Q4 2025), and $17.6 million (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Net Cash Flow (Qtr)
1 Quantum Biopharma 961,148.99 Bn 961,148.98 Bn - 2.44 Mn
2 Alterity Therapeutics 744,933.29 Bn 744,933.26 Bn - -
3 Legend Biotech 2,540.00 Bn 2,539.71 Bn 242.10 Mn 625.70 Mn
4 Nanobiotix 2,199.85 Bn 2,199.78 Bn - -
5 Akari Therapeutics 1,635.88 Bn 1,635.88 Bn - -2.44 Mn
6 Vertex Pharmaceuticals 111.32 Bn 104.07 Bn 2.59 Bn 457.40 Mn
7 Evaxion A 62.56 Bn 62.54 Bn - -
8 Regeneron Pharmaceuticals 62.55 Bn 53.79 Bn 3.31 Bn -152.20 Mn
9 Alnylam Pharmaceuticals 39.57 Bn 36.56 Bn 959.66 Mn 60.68 Mn
10 Prime Medicine 601.24 Mn 601.24 Mn - 1.07 Mn

Historic Data

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DateValue
Mar 31, 2026 1.07 Mn
Mar 31, 2026 1.07 Mn
Dec 31, 2025 -8.36 Mn
Dec 31, 2025 -8.36 Mn
Sep 30, 2025 17.59 Mn
Sep 30, 2025 17.59 Mn
Jun 30, 2025 -38.44 Mn
Jun 30, 2025 -38.44 Mn
Mar 31, 2025 -90.60 Mn
Mar 31, 2025 -90.60 Mn
Dec 31, 2024 64.50 Mn
Dec 31, 2024 64.50 Mn
Sep 30, 2024 62.94 Mn
Sep 30, 2024 62.94 Mn
Jun 30, 2024 -38.56 Mn
Jun 30, 2024 -38.56 Mn
Mar 31, 2024 52.59 Mn
Mar 31, 2024 52.59 Mn
Dec 31, 2023 -2.39 Mn
Dec 31, 2023 -2.39 Mn
Sep 30, 2023 -76.62 Mn
Sep 30, 2023 -76.62 Mn
Jun 30, 2023 -12.89 Mn
Jun 30, 2023 -12.89 Mn
Mar 31, 2023 -54.16 Mn
Mar 31, 2023 -54.16 Mn
Dec 31, 2022 139.67 Mn
Dec 31, 2022 139.67 Mn
Sep 30, 2022 -44.29 Mn
Sep 30, 2022 -44.29 Mn
Jun 30, 2022 -71.64 Mn
Jun 30, 2022 -71.64 Mn
Mar 31, 2022 -21.17 Mn
Mar 31, 2022 -21.17 Mn
Dec 31, 2021 -2.12 Mn
Dec 31, 2021 -2.12 Mn