Prime Medicine (PRME) Free Cash Flow (2021 - 2026)
Prime Medicine's (PRME) quarterly Free Cash Flow came in at -$42.7 million in Q1 2026, up 16.71% YoY from -$36.6 million in Q1 2025, and down 13.75% on a QoQ basis from -$37.5 million in Q4 2025.
Analysis
Prime Medicine (PRME) Free Cash Flow (2021 - 2026) Analysis & Trends
Prime Medicine (PRME) has 6 years of Free Cash Flow data on file, last reported at -$42.7 million in Q1 2026.
- Quarterly Free Cash Flow rose 16.71% year-over-year to -$42.7 million in Q1 2026, while the trailing twelve-month figure through Mar 2026 was -$158.5 million (down 48.49% YoY) and the FY2025 annual result came in at -$167.1 million, down 34.73% from the prior year.
- Free Cash Flow declined to -$42.7 million in Q1 2026, from -$37.5 million in the prior quarter.
- In the past five years, Free Cash Flow ranged from a high of $15.2 million in Q4 2024 to a low of -$68.5 million in Q1 2024.
- A 5-year average of -$37.7 million and a median of -$39.1 million in 2025 frame the typical range for Free Cash Flow.
- Annual changes were most pronounced in 2024 — Free Cash Flow soared 129.19% — and 2025, when it tumbled 346.98%.
- Tracing PRME's Free Cash Flow over 5 years: stood at -$20.4 million in 2022, then tumbled by 155.26% to -$52.1 million in 2023, then soared by 129.19% to $15.2 million in 2024, then sank by 346.98% to -$37.5 million in 2025, then dropped by 13.75% to -$42.7 million in 2026.
- The last three Free Cash Flow figures came in at -$42.7 million (Q1 2026), -$37.5 million (Q4 2025), and -$39.1 million (Q3 2025), per Business Quant data.
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Free Cash Flow (Qtr) |
|---|---|---|---|---|---|
| 1 | Vertex Pharmaceuticals | 138.47 Bn | 130.62 Bn | 2.84 Bn | 1.01 Bn |
| 2 | Regeneron Pharmaceuticals | 85.18 Bn | 77.19 Bn | 3.93 Bn | 572.80 Mn |
| 3 | Argenx Se | 63.38 Bn | 58.19 Bn | 1.37 Bn | - |
| 4 | Moderna | 58.09 Bn | 52.95 Bn | 52.00 Mn | -563.00 Mn |
| 5 | Revolution Medicines | 44.33 Bn | 44.33 Bn | - | -389.61 Mn |
| 6 | BeOne Medicines | 40.02 Bn | 34.92 Bn | 1.53 Bn | 437.80 Mn |
| 7 | Alnylam Pharmaceuticals | 35.57 Bn | 32.27 Bn | 992.69 Mn | 292.04 Mn |
| 8 | Royalty Pharma | 28.45 Bn | 27.61 Bn | - | 477.44 Mn |
| 9 | Insmed | 27.48 Bn | 26.32 Bn | 358.27 Mn | -95.09 Mn |
| 10 | Prime Medicine | 653.96 Mn | 653.96 Mn | - | -41.09 Mn |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -41.09 Mn |
| Mar 31, 2026 | -42.92 Mn |
| Dec 31, 2025 | -37.55 Mn |
| Sep 30, 2025 | -35.29 Mn |
| Jun 30, 2025 | -42.98 Mn |
| Mar 31, 2025 | -51.28 Mn |
| Dec 31, 2024 | 14.45 Mn |
| Sep 30, 2024 | -27.19 Mn |
| Jun 30, 2024 | -47.39 Mn |
| Mar 31, 2024 | -70.03 Mn |
| Dec 31, 2023 | -45.70 Mn |
| Sep 30, 2023 | -42.08 Mn |
| Jun 30, 2023 | -42.19 Mn |
| Mar 31, 2023 | -44.16 Mn |
| Dec 31, 2022 | -35.53 Mn |
| Sep 30, 2022 | -34.89 Mn |
| Jun 30, 2022 | -25.03 Mn |
| Mar 31, 2022 | -52.48 Mn |
| Dec 31, 2021 | -13.57 Mn |