Prime Medicine PRME
NASDAQ PRME
$3.70 -0.01 (-0.27%)
As of: Sep 4, 2026 · 3:59 PM EDT

Prime Medicine (PRME) Free Cash Flow (2021 - 2026)

Prime Medicine's (PRME) quarterly Free Cash Flow came in at -$42.7 million in Q1 2026, up 16.71% YoY from -$36.6 million in Q1 2025, and down 13.75% on a QoQ basis from -$37.5 million in Q4 2025.

Analysis

Prime Medicine (PRME) Free Cash Flow (2021 - 2026) Analysis & Trends

Prime Medicine (PRME) has 6 years of Free Cash Flow data on file, last reported at -$42.7 million in Q1 2026.

  • Quarterly Free Cash Flow rose 16.71% year-over-year to -$42.7 million in Q1 2026, while the trailing twelve-month figure through Mar 2026 was -$158.5 million (down 48.49% YoY) and the FY2025 annual result came in at -$167.1 million, down 34.73% from the prior year.
  • Free Cash Flow declined to -$42.7 million in Q1 2026, from -$37.5 million in the prior quarter.
  • In the past five years, Free Cash Flow ranged from a high of $15.2 million in Q4 2024 to a low of -$68.5 million in Q1 2024.
  • A 5-year average of -$37.7 million and a median of -$39.1 million in 2025 frame the typical range for Free Cash Flow.
  • Annual changes were most pronounced in 2024 — Free Cash Flow soared 129.19% — and 2025, when it tumbled 346.98%.
  • Tracing PRME's Free Cash Flow over 5 years: stood at -$20.4 million in 2022, then tumbled by 155.26% to -$52.1 million in 2023, then soared by 129.19% to $15.2 million in 2024, then sank by 346.98% to -$37.5 million in 2025, then dropped by 13.75% to -$42.7 million in 2026.
  • The last three Free Cash Flow figures came in at -$42.7 million (Q1 2026), -$37.5 million (Q4 2025), and -$39.1 million (Q3 2025), per Business Quant data.
Peer Set

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Free Cash Flow (Qtr)
1 Vertex Pharmaceuticals 138.47 Bn 130.62 Bn 2.84 Bn 1.01 Bn
2 Regeneron Pharmaceuticals 85.18 Bn 77.19 Bn 3.93 Bn 572.80 Mn
3 Argenx Se 63.38 Bn 58.19 Bn 1.37 Bn -
4 Moderna 58.09 Bn 52.95 Bn 52.00 Mn -563.00 Mn
5 Revolution Medicines 44.33 Bn 44.33 Bn - -389.61 Mn
6 BeOne Medicines 40.02 Bn 34.92 Bn 1.53 Bn 437.80 Mn
7 Alnylam Pharmaceuticals 35.57 Bn 32.27 Bn 992.69 Mn 292.04 Mn
8 Royalty Pharma 28.45 Bn 27.61 Bn - 477.44 Mn
9 Insmed 27.48 Bn 26.32 Bn 358.27 Mn -95.09 Mn
10 Prime Medicine 653.96 Mn 653.96 Mn - -41.09 Mn
Historic Data

Historic Data

Download Data
DateValue
Jun 30, 2026 -41.09 Mn
Mar 31, 2026 -42.92 Mn
Dec 31, 2025 -37.55 Mn
Sep 30, 2025 -35.29 Mn
Jun 30, 2025 -42.98 Mn
Mar 31, 2025 -51.28 Mn
Dec 31, 2024 14.45 Mn
Sep 30, 2024 -27.19 Mn
Jun 30, 2024 -47.39 Mn
Mar 31, 2024 -70.03 Mn
Dec 31, 2023 -45.70 Mn
Sep 30, 2023 -42.08 Mn
Jun 30, 2023 -42.19 Mn
Mar 31, 2023 -44.16 Mn
Dec 31, 2022 -35.53 Mn
Sep 30, 2022 -34.89 Mn
Jun 30, 2022 -25.03 Mn
Mar 31, 2022 -52.48 Mn
Dec 31, 2021 -13.57 Mn