Prime Medicine (PRME) Enterprise Value (2021 - 2026)
Prime Medicine (PRME) posted Enterprise Value of -$135.5 million for Q1 2026, up 23.74% on a QoQ basis from -$177.7 million in Q4 2025, and down 41.45% year-over-year from -$231.4 million in Q1 2025.
Prime Medicine (PRME) Enterprise Value (2021 - 2026) Analysis & Trends
Prime Medicine's Enterprise Value history runs 6 years deep, the most recent figure standing at -$135.5 million for Q1 2026.
- Quarterly Enterprise Value fell 41.45% year-over-year to -$135.5 million in Q1 2026, while the trailing twelve-month figure through Mar 2026 was -$135.5 million (down 41.45% YoY) and the FY2025 annual result came in at -$177.7 million, up 4.2% from the prior year.
- Enterprise Value was -$135.5 million for Q1 2026 at Prime Medicine, up from -$177.7 million in the prior quarter.
- Across five years, Enterprise Value topped out at -$47.0 million in Q4 2023 and bottomed at -$286.1 million in Q4 2022.
- A 5-year average of -$132.7 million and a median of -$127.0 million in 2023 frame the typical range for Enterprise Value.
- Annual changes were most pronounced in 2023 — Enterprise Value surged 83.56% — and 2024, when it tumbled 294.41%.
- Prime Medicine's Enterprise Value stood at -$286.1 million in 2022, then surged by 83.56% to -$47.0 million in 2023, then tumbled by 294.41% to -$185.5 million in 2024, then increased by 4.2% to -$177.7 million in 2025, then increased by 23.74% to -$135.5 million in 2026.
- Business Quant data shows PRME's Enterprise Value at -$135.5 million in Q1 2026, -$177.7 million in Q4 2025, and -$76.3 million in Q3 2025.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Enterprise Value (Qtr) |
|---|---|---|---|---|---|
| 1 | Oculis Holding AG | 68,785.72 Bn | 68,785.72 Bn | - | -283.54 Mn |
| 2 | Nanobiotix | 1,895.57 Bn | 1,895.51 Bn | - | -61.40 Mn |
| 3 | BeOne Medicines | 471.35 Bn | 466.56 Bn | 1.35 Bn | -4.79 Bn |
| 4 | NuCana | 279.75 Bn | 279.75 Bn | - | -32.26 Mn |
| 5 | Vertex Pharmaceuticals | 120.24 Bn | 113.00 Bn | 2.59 Bn | -7.25 Bn |
| 6 | Regeneron Pharmaceuticals | 67.80 Bn | 59.04 Bn | 3.31 Bn | -8.75 Bn |
| 7 | Belite Bio | 62.51 Bn | 62.51 Bn | - | - |
| 8 | Argenx Se | 57.38 Bn | 57.38 Bn | 1.41 Bn | -5.18 Bn |
| 9 | Revolution Medicines | 37.78 Bn | 37.78 Bn | - | -1.91 Bn |
| 10 | Prime Medicine | 525.98 Mn | 525.98 Mn | - | -135.50 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -135.50 Mn |
| Dec 31, 2025 | -177.68 Mn |
| Sep 30, 2025 | -76.26 Mn |
| Jun 30, 2025 | -57.21 Mn |
| Mar 31, 2025 | -95.79 Mn |
| Dec 31, 2024 | -185.47 Mn |
| Sep 30, 2024 | -122.89 Mn |
| Jun 30, 2024 | -158.18 Mn |
| Mar 31, 2024 | -100.78 Mn |
| Dec 31, 2023 | -47.03 Mn |
| Sep 30, 2023 | -48.78 Mn |
| Jun 30, 2023 | -126.97 Mn |
| Mar 31, 2023 | -243.39 Mn |
| Dec 31, 2022 | -286.09 Mn |
| Sep 30, 2022 | -137.12 Mn |
| Jun 30, 2022 | -92.24 Mn |
| Mar 31, 2022 | -164.25 Mn |
| Dec 31, 2021 | -117.74 Mn |
| Sep 30, 2021 | -200.66 Mn |