Prime Medicine (PRME) EBITDA Margin (2024 - 2026)
Prime Medicine posted quarterly EBITDA Margin of 5748.25% for Q1 2026, down 217837.0% year-on-year from N/an in Q1 2025, and down 4.65% on a QoQ basis from 5492.84% in Q4 2025.
Prime Medicine (PRME) has 3 years of EBITDA Margin data on file, last reported at 5748.25% in Q1 2026.
- For the quarter ending Q1 2026, EBITDA Margin fell 217837.0% year-over-year to 5748.25%; the trailing twelve-month figure through Mar 2026 stood at 4917.2% (up 33321.0% YoY), and the FY2025 full-year result was 4340.7%, up 222538.0% from the prior year.
- EBITDA Margin for Q1 2026 stood at 5748.25%, down from 5492.84% in the prior quarter.
- Across five years, EBITDA Margin topped out at 1937.52% in Q4 2024 and bottomed at 25084.21% in Q3 2024.
- The 3-year median for EBITDA Margin is 5104.54% (2025), against an average of 7303.88%.
- Peak annual rise in EBITDA Margin reached 2095858 bps in 2025, while the deepest fall reached 355532 bps in 2025.
- A 3-year view of EBITDA Margin shows it stood at 1937.52% in 2024, then tumbled by 183 bps to 5492.84% in 2025, then dropped by 5 bps to 5748.25% in 2026.
- The last three EBITDA Margin figures came in at 5748.25% (Q1 2026), 5492.84% (Q4 2025), and 4125.63% (Q3 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBITDA Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Quantum Biopharma | 961,148.99 Bn | 961,148.98 Bn | - | - |
| 2 | Alterity Therapeutics | 744,933.29 Bn | 744,933.26 Bn | - | - |
| 3 | Legend Biotech | 2,540.00 Bn | 2,539.71 Bn | 242.10 Mn | -6.43% |
| 4 | Nanobiotix | 2,199.85 Bn | 2,199.78 Bn | - | - |
| 5 | Akari Therapeutics | 1,635.88 Bn | 1,635.88 Bn | - | - |
| 6 | Vertex Pharmaceuticals | 111.32 Bn | 104.07 Bn | 2.59 Bn | 38.10% |
| 7 | Evaxion A | 62.56 Bn | 62.54 Bn | - | - |
| 8 | Regeneron Pharmaceuticals | 62.55 Bn | 53.79 Bn | 3.31 Bn | 18.35% |
| 9 | Alnylam Pharmaceuticals | 39.57 Bn | 36.56 Bn | 959.66 Mn | 17.24% |
| 10 | Prime Medicine | 601.24 Mn | 601.24 Mn | - | -5,748.25% |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -5,748.25% |
| Dec 31, 2025 | -5,492.84% |
| Sep 30, 2025 | -4,125.63% |
| Jun 30, 2025 | -4,716.23% |
| Mar 31, 2025 | -3,569.88% |
| Dec 31, 2024 | -1,937.52% |
| Sep 30, 2024 | -25,084.21% |
| Mar 31, 2024 | -7,756.51% |