Prime Medicine (PRME) EBITDA Margin (2024 - 2026)
Prime Medicine's (PRME) quarterly EBITDA Margin came in at 5917.52% in Q1 2026, down 231422.0% YoY from N/an in Q1 2025, and down 2.02% on a QoQ basis from 5800.48% in Q4 2025.
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Prime Medicine (PRME) EBITDA Margin (2024 - 2026) Analysis & Trends
Prime Medicine (PRME) has 3 years of EBITDA Margin data on file, last reported at 5917.52% in Q1 2026.
- Quarterly EBITDA Margin fell 231422.0% year-over-year to 5917.52% in Q1 2026, while the trailing twelve-month figure through Mar 2026 was 5121.76% (up 24792.0% YoY) and the FY2025 annual result came in at 4498.06%, up 228930.0% from the prior year.
- EBITDA Margin declined to 5917.52% in Q1 2026, from 5800.48% in the prior quarter.
- In the past five years, EBITDA Margin ranged from a high of 2025.74% in Q4 2024 to a low of 25948.33% in Q3 2024.
- A 3-year average of 7583.5% and a median of 5293.83% in 2025 frame the typical range for EBITDA Margin.
- The widest YoY moves for EBITDA Margin: up 2154237 bps in 2025, down 377473 bps in 2025.
- Tracing PRME's EBITDA Margin over 3 years: stood at 2025.74% in 2024, then slumped by 186 bps to 5800.48% in 2025, then decreased by 2 bps to 5917.52% in 2026.
- The last three EBITDA Margin figures came in at 5917.52% (Q1 2026), 5800.48% (Q4 2025), and 4405.96% (Q3 2025), per Business Quant data.
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBITDA Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Vertex Pharmaceuticals | 138.47 Bn | 130.62 Bn | 2.84 Bn | 37.40% |
| 2 | Regeneron Pharmaceuticals | 85.18 Bn | 77.19 Bn | 3.93 Bn | 30.15% |
| 3 | Argenx Se | 63.38 Bn | 58.19 Bn | 1.37 Bn | 32.54% |
| 4 | Moderna | 58.09 Bn | 52.95 Bn | 52.00 Mn | -562.07% |
| 5 | Revolution Medicines | 44.33 Bn | 44.33 Bn | - | - |
| 6 | BeOne Medicines | 40.02 Bn | 34.92 Bn | 1.53 Bn | 19.06% |
| 7 | Alnylam Pharmaceuticals | 35.57 Bn | 32.27 Bn | 992.69 Mn | 17.93% |
| 8 | Royalty Pharma | 28.45 Bn | 27.61 Bn | - | 19.75% |
| 9 | Insmed | 27.48 Bn | 26.32 Bn | 358.27 Mn | -0.36% |
| 10 | Prime Medicine | 653.96 Mn | 653.96 Mn | - | -3,750.87% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -3,750.87% |
| Mar 31, 2026 | -5,917.52% |
| Dec 31, 2025 | -5,800.48% |
| Sep 30, 2025 | -4,405.96% |
| Jun 30, 2025 | -4,787.17% |
| Mar 31, 2025 | -3,603.30% |
| Dec 31, 2024 | -2,025.74% |
| Sep 30, 2024 | -25,948.33% |
| Mar 31, 2024 | -8,179.53% |