Prime Medicine (PRME) Change in Cash (2021 - 2026)
Prime Medicine's (PRME) quarterly Change in Cash came in at $1.1 million in Q1 2026, up 101.19% YoY from $533835.8 in Q1 2025, and up 112.84% on a QoQ basis from -$8.4 million in Q4 2025.
Analysis
Prime Medicine (PRME) Change in Cash (2021 - 2026) Analysis & Trends
Prime Medicine (PRME) has 6 years of Change in Cash data on file, last reported at $1.1 million in Q1 2026.
- Quarterly Change in Cash rose 101.19% year-over-year to $1.1 million in Q1 2026, while the trailing twelve-month figure through Mar 2026 was -$28.1 million (down 1537.11% YoY) and the FY2025 annual result came in at -$119.8 million, down 184.69% from the prior year.
- Change in Cash grew to $1.1 million in Q1 2026, from -$8.4 million in the prior quarter.
- In the past five years, Change in Cash ranged from a high of $139.7 million in Q4 2022 to a low of -$90.6 million in Q1 2025.
- A 5-year average of -$7.1 million and a median of -$12.9 million in 2023 frame the typical range for Change in Cash.
- Annual changes were most pronounced in 2022 — Change in Cash soared 6691.46% — and 2025, when it sank 272.28%.
- Tracing PRME's Change in Cash over 5 years: stood at $139.7 million in 2022, then sank by 101.71% to -$2.4 million in 2023, then jumped by 2804.36% to $64.5 million in 2024, then plunged by 112.97% to -$8.4 million in 2025, then soared by 112.84% to $1.1 million in 2026.
- The last three Change in Cash figures came in at $1.1 million (Q1 2026), -$8.4 million (Q4 2025), and $17.6 million (Q3 2025), per Business Quant data.
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Change in Cash (Qtr) |
|---|---|---|---|---|---|
| 1 | Vertex Pharmaceuticals | 138.47 Bn | 130.62 Bn | 2.84 Bn | 649.20 Mn |
| 2 | Regeneron Pharmaceuticals | 85.18 Bn | 77.19 Bn | 3.93 Bn | -504.60 Mn |
| 3 | Argenx Se | 63.38 Bn | 58.19 Bn | 1.37 Bn | - |
| 4 | Moderna | 58.09 Bn | 52.95 Bn | 52.00 Mn | -185.00 Mn |
| 5 | Revolution Medicines | 44.33 Bn | 44.33 Bn | - | 374.50 Mn |
| 6 | BeOne Medicines | 40.02 Bn | 34.92 Bn | 1.53 Bn | 427.25 Mn |
| 7 | Alnylam Pharmaceuticals | 35.57 Bn | 32.27 Bn | 992.69 Mn | -2.94 Mn |
| 8 | Royalty Pharma | 28.45 Bn | 27.61 Bn | - | 225.59 Mn |
| 9 | Insmed | 27.48 Bn | 26.32 Bn | 358.27 Mn | -37.42 Mn |
| 10 | Prime Medicine | 653.96 Mn | 653.96 Mn | - | -16.66 Mn |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -16.66 Mn |
| Mar 31, 2026 | 1.07 Mn |
| Dec 31, 2025 | -8.36 Mn |
| Sep 30, 2025 | 17.59 Mn |
| Jun 30, 2025 | -38.44 Mn |
| Mar 31, 2025 | -90.60 Mn |
| Dec 31, 2024 | 64.50 Mn |
| Sep 30, 2024 | 62.94 Mn |
| Jun 30, 2024 | -38.56 Mn |
| Mar 31, 2024 | 52.59 Mn |
| Dec 31, 2023 | -2.39 Mn |
| Sep 30, 2023 | -76.62 Mn |
| Jun 30, 2023 | -12.89 Mn |
| Mar 31, 2023 | -54.16 Mn |
| Dec 31, 2022 | 139.67 Mn |
| Sep 30, 2022 | -44.29 Mn |
| Jun 30, 2022 | -71.64 Mn |
| Mar 31, 2022 | -21.17 Mn |
| Dec 31, 2021 | -2.12 Mn |