Prime Medicine (PRME) Change in Cash (2021 - 2026)
Prime Medicine (PRME) reported Change in Cash of $1.1 million for Q1 2026, up 101.19% on a YoY basis from $533835.8 in Q1 2025, and up 112.84% quarter-over-quarter from -$8.4 million in Q4 2025.
Prime Medicine (PRME) Change in Cash (2021 - 2026) Analysis & Trends
Prime Medicine has reported Change in Cash for 6 years, with the latest figure at $1.1 million in Q1 2026.
- For the quarter ending Q1 2026, Change in Cash rose 101.19% year-over-year to $1.1 million; the trailing twelve-month figure through Mar 2026 stood at -$28.1 million (down 1537.11% YoY), and the FY2025 full-year result was -$119.8 million, down 184.69% from the prior year.
- Change in Cash for Q1 2026 stood at $1.1 million, up from -$8.4 million in the prior quarter.
- The five-year high for Change in Cash was $139.7 million in Q4 2022, with the low at -$90.6 million in Q1 2025.
- Historically, Change in Cash has averaged -$7.1 million across 5 years, with a median of -$12.9 million in 2023.
- Annual changes were most pronounced in 2022 — Change in Cash soared 6691.46% — and 2025, when it sank 272.28%.
- Prime Medicine's Change in Cash stood at $139.7 million in 2022, then sank by 101.71% to -$2.4 million in 2023, then jumped by 2804.36% to $64.5 million in 2024, then plunged by 112.97% to -$8.4 million in 2025, then soared by 112.84% to $1.1 million in 2026.
- The last three Change in Cash figures came in at $1.1 million (Q1 2026), -$8.4 million (Q4 2025), and $17.6 million (Q3 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Change in Cash (Qtr) |
|---|---|---|---|---|---|
| 1 | Alterity Therapeutics | 925,601.88 Bn | 925,601.85 Bn | - | - |
| 2 | Belite Bio | 58,560.00 Bn | 58,560.00 Bn | - | - |
| 3 | Quantum Biopharma | 17,284.41 Bn | 17,284.40 Bn | - | 2.44 Mn |
| 4 | Legend Biotech | 2,809.00 Bn | 2,808.71 Bn | 242.10 Mn | 623.00 Mn |
| 5 | Evaxion A | 1,334.43 Bn | 1,334.42 Bn | - | - |
| 6 | Akari Therapeutics | 1,312.27 Bn | 1,312.26 Bn | - | -2.44 Mn |
| 7 | Psyence Biomedical | 212.16 Bn | 212.16 Bn | - | - |
| 8 | Vertex Pharmaceuticals | 114.83 Bn | 107.58 Bn | 2.59 Bn | 417.10 Mn |
| 9 | Abivax | 91.96 Bn | 91.96 Bn | - | -45.97 Mn |
| 10 | Prime Medicine | 572.02 Mn | 572.02 Mn | - | 1.07 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | 1.07 Mn |
| Dec 31, 2025 | -8.36 Mn |
| Sep 30, 2025 | 17.59 Mn |
| Jun 30, 2025 | -38.44 Mn |
| Mar 31, 2025 | -90.60 Mn |
| Dec 31, 2024 | 64.50 Mn |
| Sep 30, 2024 | 62.94 Mn |
| Jun 30, 2024 | -38.56 Mn |
| Mar 31, 2024 | 52.59 Mn |
| Dec 31, 2023 | -2.39 Mn |
| Sep 30, 2023 | -76.62 Mn |
| Jun 30, 2023 | -12.89 Mn |
| Mar 31, 2023 | -54.16 Mn |
| Dec 31, 2022 | 139.67 Mn |
| Sep 30, 2022 | -44.29 Mn |
| Jun 30, 2022 | -71.64 Mn |
| Mar 31, 2022 | -21.17 Mn |
| Dec 31, 2021 | -2.12 Mn |