Prime Medicine (PRME) Change in Cash (2021 - 2026)
Prime Medicine (PRME) posted Change in Cash of $1.1 million for Q1 2026, up 112.84% on a QoQ basis from -$8.4 million in Q4 2025, and up 101.19% year-over-year from $533835.8 in Q1 2025.
Prime Medicine (PRME) Change in Cash (2021 - 2026) Analysis & Trends
Prime Medicine's Change in Cash history runs 6 years deep, the most recent figure standing at $1.1 million for Q1 2026.
- Quarterly Change in Cash rose 101.19% year-over-year to $1.1 million in Q1 2026, while the trailing twelve-month figure through Mar 2026 was -$28.1 million (down 1537.11% YoY) and the FY2025 annual result came in at -$119.8 million, down 184.69% from the prior year.
- Change in Cash was $1.1 million for Q1 2026 at Prime Medicine, up from -$8.4 million in the prior quarter.
- Across five years, Change in Cash topped out at $139.7 million in Q4 2022 and bottomed at -$90.6 million in Q1 2025.
- A 5-year average of -$7.1 million and a median of -$12.9 million in 2023 frame the typical range for Change in Cash.
- Annual changes were most pronounced in 2022 — Change in Cash soared 6691.46% — and 2025, when it plunged 272.28%.
- Prime Medicine's Change in Cash stood at $139.7 million in 2022, then tumbled by 101.71% to -$2.4 million in 2023, then soared by 2804.36% to $64.5 million in 2024, then slumped by 112.97% to -$8.4 million in 2025, then surged by 112.84% to $1.1 million in 2026.
- Business Quant data shows PRME's Change in Cash at $1.1 million in Q1 2026, -$8.4 million in Q4 2025, and $17.6 million in Q3 2025.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Change in Cash (Qtr) |
|---|---|---|---|---|---|
| 1 | Oculis Holding AG | 68,785.72 Bn | 68,785.72 Bn | - | -22.03 Mn |
| 2 | Nanobiotix | 1,895.57 Bn | 1,895.51 Bn | - | - |
| 3 | BeOne Medicines | 471.35 Bn | 466.56 Bn | 1.35 Bn | 243.78 Mn |
| 4 | NuCana | 279.75 Bn | 279.75 Bn | - | -1.34 Mn |
| 5 | Vertex Pharmaceuticals | 120.24 Bn | 113.00 Bn | 2.59 Bn | 417.10 Mn |
| 6 | Regeneron Pharmaceuticals | 67.80 Bn | 59.04 Bn | 3.31 Bn | -153.10 Mn |
| 7 | Belite Bio | 62.51 Bn | 62.51 Bn | - | - |
| 8 | Argenx Se | 57.38 Bn | 57.38 Bn | 1.41 Bn | - |
| 9 | Revolution Medicines | 37.78 Bn | 37.78 Bn | - | 57.19 Mn |
| 10 | Prime Medicine | 525.98 Mn | 525.98 Mn | - | 1.07 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | 1.07 Mn |
| Dec 31, 2025 | -8.36 Mn |
| Sep 30, 2025 | 17.59 Mn |
| Jun 30, 2025 | -38.44 Mn |
| Mar 31, 2025 | -90.60 Mn |
| Dec 31, 2024 | 64.50 Mn |
| Sep 30, 2024 | 62.94 Mn |
| Jun 30, 2024 | -38.56 Mn |
| Mar 31, 2024 | 52.59 Mn |
| Dec 31, 2023 | -2.39 Mn |
| Sep 30, 2023 | -76.62 Mn |
| Jun 30, 2023 | -12.89 Mn |
| Mar 31, 2023 | -54.16 Mn |
| Dec 31, 2022 | 139.67 Mn |
| Sep 30, 2022 | -44.29 Mn |
| Jun 30, 2022 | -71.64 Mn |
| Mar 31, 2022 | -21.17 Mn |
| Dec 31, 2021 | -2.12 Mn |