Prime Medicine (PRME) Change in Cash (2021 - 2026)

Prime Medicine (PRME) reported Change in Cash of $1.1 million for Q1 2026, up 101.19% on a YoY basis from $533835.8 in Q1 2025, and up 112.84% quarter-over-quarter from -$8.4 million in Q4 2025.

Prime Medicine (PRME) Change in Cash (2021 - 2026) Analysis & Trends

Prime Medicine has reported Change in Cash for 6 years, with the latest figure at $1.1 million in Q1 2026.

  • For the quarter ending Q1 2026, Change in Cash rose 101.19% year-over-year to $1.1 million; the trailing twelve-month figure through Mar 2026 stood at -$28.1 million (down 1537.11% YoY), and the FY2025 full-year result was -$119.8 million, down 184.69% from the prior year.
  • Change in Cash for Q1 2026 stood at $1.1 million, up from -$8.4 million in the prior quarter.
  • The five-year high for Change in Cash was $139.7 million in Q4 2022, with the low at -$90.6 million in Q1 2025.
  • Historically, Change in Cash has averaged -$7.1 million across 5 years, with a median of -$12.9 million in 2023.
  • Annual changes were most pronounced in 2022 — Change in Cash soared 6691.46% — and 2025, when it sank 272.28%.
  • Prime Medicine's Change in Cash stood at $139.7 million in 2022, then sank by 101.71% to -$2.4 million in 2023, then jumped by 2804.36% to $64.5 million in 2024, then plunged by 112.97% to -$8.4 million in 2025, then soared by 112.84% to $1.1 million in 2026.
  • The last three Change in Cash figures came in at $1.1 million (Q1 2026), -$8.4 million (Q4 2025), and $17.6 million (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Change in Cash (Qtr)
1 Alterity Therapeutics 925,601.88 Bn 925,601.85 Bn - -
2 Belite Bio 58,560.00 Bn 58,560.00 Bn - -
3 Quantum Biopharma 17,284.41 Bn 17,284.40 Bn - 2.44 Mn
4 Legend Biotech 2,809.00 Bn 2,808.71 Bn 242.10 Mn 623.00 Mn
5 Evaxion A 1,334.43 Bn 1,334.42 Bn - -
6 Akari Therapeutics 1,312.27 Bn 1,312.26 Bn - -2.44 Mn
7 Psyence Biomedical 212.16 Bn 212.16 Bn - -
8 Vertex Pharmaceuticals 114.83 Bn 107.58 Bn 2.59 Bn 417.10 Mn
9 Abivax 91.96 Bn 91.96 Bn - -45.97 Mn
10 Prime Medicine 572.02 Mn 572.02 Mn - 1.07 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 1.07 Mn
Dec 31, 2025 -8.36 Mn
Sep 30, 2025 17.59 Mn
Jun 30, 2025 -38.44 Mn
Mar 31, 2025 -90.60 Mn
Dec 31, 2024 64.50 Mn
Sep 30, 2024 62.94 Mn
Jun 30, 2024 -38.56 Mn
Mar 31, 2024 52.59 Mn
Dec 31, 2023 -2.39 Mn
Sep 30, 2023 -76.62 Mn
Jun 30, 2023 -12.89 Mn
Mar 31, 2023 -54.16 Mn
Dec 31, 2022 139.67 Mn
Sep 30, 2022 -44.29 Mn
Jun 30, 2022 -71.64 Mn
Mar 31, 2022 -21.17 Mn
Dec 31, 2021 -2.12 Mn