Prime Medicine (PRME) Change in Accured Expenses (2021 - 2026)

Prime Medicine posted quarterly Change in Accured Expenses of -$4.5 million for Q1 2026, up 32.35% year-on-year from -$3.4 million in Q1 2025, and down 381.38% on a QoQ basis from $1.6 million in Q4 2025.

Prime Medicine (PRME) has 6 years of Change in Accured Expenses data on file, last reported at -$4.5 million in Q1 2026.

  • For the quarter ending Q1 2026, Change in Accured Expenses rose 32.35% year-over-year to -$4.5 million; the trailing twelve-month figure through Mar 2026 stood at $993000.0 (up 394.66% YoY), and the FY2025 full-year result was -$1.2 million, down 162.94% from the prior year.
  • Change in Accured Expenses for Q1 2026 stood at -$4.5 million, down from $1.6 million in the prior quarter.
  • Across five years, Change in Accured Expenses topped out at $5.9 million in Q3 2024 and bottomed at -$33.3 million in Q1 2022.
  • The 5-year median for Change in Accured Expenses is $608000.0 (2023), against an average of -$1.6 million.
  • Peak annual rise in Change in Accured Expenses reached 1211.11% in 2025, while the deepest fall reached 118.06% in 2025.
  • A 5-year view of Change in Accured Expenses shows it stood at $4.1 million in 2022, then slumped by 38.53% to $2.5 million in 2023, then plunged by 105.73% to -$144000.0 in 2024, then jumped by 1211.11% to $1.6 million in 2025, then plunged by 381.38% to -$4.5 million in 2026.
  • The last three Change in Accured Expenses figures came in at -$4.5 million (Q1 2026), $1.6 million (Q4 2025), and -$1.1 million (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Change in Accured Expenses (Qtr)
1 Quantum Biopharma 961,148.99 Bn 961,148.98 Bn - -
2 Alterity Therapeutics 744,933.29 Bn 744,933.26 Bn - -
3 Legend Biotech 2,540.00 Bn 2,539.71 Bn 242.10 Mn -
4 Nanobiotix 2,199.85 Bn 2,199.78 Bn - -
5 Akari Therapeutics 1,635.88 Bn 1,635.88 Bn - 931,000.00
6 Vertex Pharmaceuticals 111.32 Bn 104.07 Bn 2.59 Bn 70.50 Mn
7 Evaxion A 62.56 Bn 62.54 Bn - -
8 Regeneron Pharmaceuticals 62.55 Bn 53.79 Bn 3.31 Bn 107.70 Mn
9 Alnylam Pharmaceuticals 39.57 Bn 36.56 Bn 959.66 Mn -176.03 Mn
10 Prime Medicine 601.24 Mn 601.24 Mn - -4.50 Mn

Historic Data

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DateValue
Mar 31, 2026 -4.50 Mn
Mar 31, 2026 -4.50 Mn
Dec 31, 2025 1.60 Mn
Dec 31, 2025 1.60 Mn
Sep 30, 2025 -1.07 Mn
Sep 30, 2025 -1.07 Mn
Jun 30, 2025 4.97 Mn
Jun 30, 2025 4.97 Mn
Mar 31, 2025 -6.66 Mn
Mar 31, 2025 -6.66 Mn
Dec 31, 2024 -144,000.00
Dec 31, 2024 -144,000.00
Sep 30, 2024 5.93 Mn
Sep 30, 2024 5.93 Mn
Jun 30, 2024 536,000.00
Jun 30, 2024 536,000.00
Mar 31, 2024 -4.48 Mn
Mar 31, 2024 -4.48 Mn
Dec 31, 2023 2.51 Mn
Dec 31, 2023 2.51 Mn
Sep 30, 2023 2.68 Mn
Sep 30, 2023 2.68 Mn
Jun 30, 2023 608,000.00
Jun 30, 2023 608,000.00
Mar 31, 2023 -4.05 Mn
Mar 31, 2023 -4.05 Mn
Dec 31, 2022 4.09 Mn
Dec 31, 2022 4.09 Mn
Sep 30, 2022 890,000.00
Sep 30, 2022 890,000.00
Jun 30, 2022 2.47 Mn
Jun 30, 2022 2.47 Mn
Mar 31, 2022 -33.32 Mn
Mar 31, 2022 -33.32 Mn
Dec 31, 2021 33.31 Mn
Dec 31, 2021 33.31 Mn