Prelude Therapeutics (PRLD) EBITDA Margin (2024 - 2026)

Prelude Therapeutics' (PRLD) quarterly EBITDA Margin came in at 227.82% in Q1 2026, up 21.9% quarter-over-quarter from 291.68% in Q4 2025.

Prelude Therapeutics (PRLD) EBITDA Margin (2024 - 2026) Analysis & Trends

Prelude Therapeutics has disclosed EBITDA Margin across 3 years of filings, most recently posting 227.82% for Q1 2026.

  • EBITDA Margin for Q1 2026 came in at 227.82%, changed N/A year-over-year; the trailing twelve-month figure through Mar 2026 was 465.62% (changed N/A YoY), and the FY2025 annual result was 819.81%, up 99963.0% from the prior year.
  • EBITDA Margin came in at 227.82% for Q1 2026 at Prelude Therapeutics, up from 291.68% in the prior quarter.
  • In the past five years, EBITDA Margin ranged from a high of 227.82% in Q1 2026 to a low of 1060.47% in Q3 2024.
  • The 3-year median for EBITDA Margin is 303.42% (2025), against an average of 520.99%.
  • Peak annual rise in EBITDA Margin reached 75705 bps in 2025, while the deepest fall reached 42989 bps in 2025.
  • Prelude Therapeutics' EBITDA Margin stood at 721.58% in 2024, then surged by 60 bps to 291.68% in 2025, then increased by 22 bps to 227.82% in 2026.
  • The last three EBITDA Margin figures came in at 227.82% (Q1 2026), 291.68% (Q4 2025), and 303.42% (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) EBITDA Margin (Qtr)
1 Alterity Therapeutics 723,416.35 Bn 723,416.32 Bn - -
2 Belite Bio 57,340.00 Bn 57,340.00 Bn - -
3 Quantum Biopharma 19,125.08 Bn 19,125.08 Bn - -
4 Legend Biotech 3,262.00 Bn 3,261.71 Bn 242.10 Mn -6.43%
5 Akari Therapeutics 1,789.67 Bn 1,789.67 Bn - -
6 Evaxion A 1,480.39 Bn 1,480.37 Bn - -
7 Psyence Biomedical 241.78 Bn 241.78 Bn - -
8 Vertex Pharmaceuticals 113.54 Bn 106.29 Bn 2.59 Bn 38.10%
9 Abivax 94.26 Bn 94.26 Bn - -
10 Prelude Therapeutics 314.40 Mn 169.80 Mn - -227.82%

Historic Data

Download Data
DateValue
Mar 31, 2026 -227.82%
Dec 31, 2025 -291.68%
Sep 30, 2025 -303.42%
Dec 31, 2024 -721.58%
Sep 30, 2024 -1,060.47%