Praxis Precision Medicines (PRAX) Operating Income (2019 - 2026)

Praxis Precision Medicines' (PRAX) quarterly Operating Income came in at -$105.9 million in Q1 2026, down 41.66% year-on-year from -$181.5 million in Q1 2025, and down 9.08% quarter-over-quarter from -$97.0 million in Q4 2025.

Praxis Precision Medicines (PRAX) Operating Income (2019 - 2026) Analysis & Trends

Praxis Precision Medicines' Operating Income history runs 8 years deep, the most recent figure standing at -$105.9 million for Q1 2026.

  • On a quarterly basis, Operating Income fell 41.66% year-over-year to -$105.9 million in Q1 2026; TTM through Mar 2026 was -$357.3 million, a 53.36% decrease from a year earlier, with the FY2025 full-year figure at -$326.2 million, down 62.96% from the prior year.
  • Operating Income fell to -$105.9 million in Q1 2026 per PRAX's latest filing, from -$97.0 million in the prior quarter.
  • Across five years, Operating Income topped out at -$25.5 million in Q3 2023 and bottomed at -$105.9 million in Q1 2026.
  • The 5-year median for Operating Income is -$56.8 million (2024), against an average of -$57.3 million.
  • Across the five-year window, Operating Income sank 151.1% in 2022 and surged 44.67% in 2023, its largest moves.
  • Year by year, Operating Income stood at -$41.5 million in 2022, then soared by 32.92% to -$27.8 million in 2023, then sank by 130.01% to -$64.0 million in 2024, then slumped by 51.74% to -$97.0 million in 2025, then fell by 9.08% to -$105.9 million in 2026.
  • Per Business Quant, the three latest PRAX Operating Income figures stand at -$105.9 million (Q1 2026), -$97.0 million (Q4 2025), and -$78.4 million (Q3 2025).

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Op. Inc (Qtr)
1 Oculis Holding AG 67,072.09 Bn 67,072.09 Bn - -27.75 Mn
2 Nanobiotix 1,894.61 Bn 1,894.55 Bn - -
3 Akari Therapeutics 1,014.18 Bn 1,014.18 Bn - -15.76 Mn
4 BeOne Medicines 471.64 Bn 466.85 Bn 1.35 Bn 249.90 Mn
5 Vertex Pharmaceuticals 121.72 Bn 114.47 Bn 2.59 Bn 1.14 Bn
6 Regeneron Pharmaceuticals 68.28 Bn 59.52 Bn 3.31 Bn 642.90 Mn
7 Belite Bio 61.40 Bn 61.40 Bn - -32.68 Mn
8 Argenx Se 56.94 Bn 56.94 Bn 1.18 Bn 394.00 Mn
9 Revolution Medicines 37.37 Bn 37.37 Bn - -445.22 Mn
10 Praxis Precision Medicines 9.37 Bn 8.58 Bn - -105.86 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 -105.86 Mn
Dec 31, 2025 -97.04 Mn
Sep 30, 2025 -78.36 Mn
Jun 30, 2025 -76.07 Mn
Mar 31, 2025 -74.73 Mn
Dec 31, 2024 -63.96 Mn
Sep 30, 2024 -56.84 Mn
Jun 30, 2024 -37.49 Mn
Mar 31, 2024 -41.89 Mn
Dec 31, 2023 -27.81 Mn
Sep 30, 2023 -25.52 Mn
Jun 30, 2023 -34.96 Mn
Mar 31, 2023 -38.09 Mn
Dec 31, 2022 -41.45 Mn
Sep 30, 2022 -44.29 Mn
Jun 30, 2022 -60.39 Mn
Mar 31, 2022 -68.85 Mn
Dec 31, 2021 -58.66 Mn
Sep 30, 2021 -44.77 Mn
Jun 30, 2021 -36.48 Mn