Praxis Precision Medicines PRAX Insider Ownership

NASDAQ PRAX

$264.49 +4.32 (+1.66%)

At close: Oct 20, 2026 · 4:00 PM EDT

The most recent Praxis Precision Medicines (PRAX) insider transaction: Marcio Souza (Chief Executive Officer) gave 20,521 shares as a gift on Jul 8, 2026. So far in the quarter ending Dec 31, 2026, insider holdings showed no net buying or selling.

Updated Oct 5, 2026 Praxis Precision Medicines (PRAX) stock price and overview

Insider Holdings by Owner

4.62Mn Shares

Insider Ownership Statistics

as of 30 Sep, 2026

Insider Ownership

15.83%

▼-0.079% pp QoQ

Shares Held by Insiders

4.61Mn

filed for Sep 2026

▼-0.50% QoQ

Shares Outstanding

29.13Mn

29,131,375 shares

Direct Holdings

189.51K

Indirect: 4.42Mn

Net Shares Traded (QoQ)

-23.12K

net selling in Sep 2026

Insiders Holding Shares

with Form 4 holdings on file

Shares Owned by Insiders

Shares held % of outstanding

Latest —

Average ownership —

Peak ownership —

Shares Purchased/Sold by Insiders

Bought Sold

Latest quarter —

Net over range —

Buying quarters —

Insider Ownership Summary

Updated Oct 5, 2026

Over the past 12 months, Praxis Precision Medicines insiders sold $44.27 million of stock on the open market (364.24K shares) and made no open-market purchases.

Counted by insider, open-market selling of PRAX stock in the past 12 months came from 4 insiders, with no insider buying.
Adage Capital Management, L.P. (10% owner) led open-market sales of Praxis Precision Medicines stock over the past 12 months with $33.2 million (313.91K shares), most recently on October 16, 2025.
The latest open-market trade on record is a sale of 11.6K shares for $3.61 million by Jill Desimone (Director) on June 24, 2026.
Apart from open-market trades, PRAX insiders received 60.15K shares in stock awards, acquired 50.33K shares through option exercises and conversions, gave up 11.57K shares to cover taxes or exercise prices and gave away 23.52K shares as gifts in the past 12 months.
Per Business Quant data, Praxis Precision Medicines insiders hold 4.61Mn shares in total based on their latest Form 4 filings, or 15.83% of the 29.13Mn shares outstanding; that total is down 0.50% from 4.63Mn shares at the end of Q2 2026.
Direct holdings account for 189.51K shares (4.11%) of PRAX's insider total, and indirect holdings through trusts, partnerships and family members for 4.42Mn shares (95.89%).
Holdings in Praxis Precision Medicines stock are reported by 14 insiders, the officers, directors and 10% owners who have filed a Form 4 in the past two years.
PRAX's three largest insider shareholders, per their latest Form 4 filings, are Adage Capital Management, L.P. (10% owner, 4.42Mn shares), Marcio Souza (Chief Executive Officer, 56.49K shares) and Timothy Edwin Kelly (Chief Financial Officer, 31.17K shares).
Adage Capital Management, L.P. alone accounts for 95.89% of the shares held by Praxis Precision Medicines insiders.
Over the trailing 12 months, 14 insiders reported transactions in PRAX stock across 35 Form 4 filings.
This summary of Praxis Precision Medicines insider activity covers Form 4 filings through July 8, 2026.

Form 4 Holdings

Insiders Holding PRAX

Insiders 16

Shares held 4.62Mn

Of outstanding 15.86%

#	Insider	Position	Direct	Indirect	Total	Share of Insiders	Last Filed
1	Capital Management, L.P. Adage	TenPercentOwner	0	4,421,660	4,421,660	95.7%	17 Oct, 2025
2	Marcio Souza	Chief Executive Officer	56,495	0	56,495	1.2%	08 Jul, 2026
3	Timothy Edwin Kelly	Chief Financial Officer	31,167	0	31,167	0.7%	19 May, 2026
4	Megan Sniecinski	Chief Operating Officer	28,664	0	28,664	0.6%	19 May, 2026
5	Alex Nemiroff	General Counsel And Secretary	26,011	0	26,011	0.6%	19 May, 2026
6	Dean J Mitchell	Director	18,622	0	18,622	0.4%	12 Jun, 2026
7	Lauren Mastrocola	Principal Accounting Officer	13,573	0	13,573	0.3%	19 May, 2026
8	Bernard Ravina	Chief Medical Officer	6,632	0	6,632	0.1%	15 Feb, 2022
9	William D Young	Director	3,269	0	3,269	0.1%	12 Jun, 2026
10	Nicole Sweeny	Chief Commercial Officer	2,575	0	2,575	0.1%	13 Feb, 2023
11	Jeffrey B Kindler	Director	2,537	0	2,537	0.1%	12 Jun, 2026
12	Stuart A Arbuckle	Director	2,537	0	2,537	0.1%	12 Jun, 2026
13	Jill Desimone	Director	2,337	0	2,337	0.1%	26 Jun, 2026
14	Gregory Norden	Director	1,559	0	1,559	0.0%	12 Jun, 2026
15	Jeffrey Chodakewitz	Director	1,371	0	1,371	0.0%	12 Jun, 2026
16	Merit Ester Cudkowicz	Director	1,371	0	1,371	0.0%	12 Jun, 2026

Each row is that insider’s most recently reported position, from Form 4 filings over the last 60 months — which is why this total does not tie to the quarterly series above, where a quarter counts only the insiders who filed in it. Shares held through a fund or institutional portfolio are counted on the institutional ownership page instead.

Form 4 Filings

325 Insider Transactions

Source SEC Form 4

Latest quarter Sep 2026

Date	Insider	Position	Transaction	Shares	Price	Value	Shares Held After	Ownership
08 Jul, 2026	Marcio Souza	Chief Executive Officer	Disposed G	20,521	$0.00	$0	56,495	Direct
08 Jul, 2026	Marcio Souza	Chief Executive Officer	Disposed G	2,600	$0.00	$0	0	Indirect
24 Jun, 2026	Jill Desimone	Director	Acquired M	8,566	$44.25	$379.05K	10,903	Direct
24 Jun, 2026	Jill Desimone	Director	Acquired M	3,034	$147.30	$446.91K	13,937	Direct
24 Jun, 2026	Jill Desimone	Director	Disposed S	10	$301.44	$3.01K	13,927	Direct
24 Jun, 2026	Jill Desimone	Director	Disposed S	120	$303.13	$36.38K	13,807	Direct
24 Jun, 2026	Jill Desimone	Director	Disposed S	320	$305.31	$97.70K	13,487	Direct
24 Jun, 2026	Jill Desimone	Director	Disposed S	683	$306.77	$209.52K	12,804	Direct
24 Jun, 2026	Jill Desimone	Director	Disposed S	1,240	$308.24	$382.22K	11,564	Direct
24 Jun, 2026	Jill Desimone	Director	Disposed S	999	$309.38	$309.07K	10,565	Direct
24 Jun, 2026	Jill Desimone	Director	Disposed S	1,750	$310.89	$544.06K	8,815	Direct
24 Jun, 2026	Jill Desimone	Director	Disposed S	2,854	$311.91	$890.20K	5,961	Direct
24 Jun, 2026	Jill Desimone	Director	Disposed S	1,004	$312.83	$314.08K	4,957	Direct
24 Jun, 2026	Jill Desimone	Director	Disposed S	504	$313.66	$158.09K	4,453	Direct
24 Jun, 2026	Jill Desimone	Director	Disposed S	1,279	$314.90	$402.76K	3,174	Direct
24 Jun, 2026	Jill Desimone	Director	Disposed S	837	$315.71	$264.25K	2,337	Direct
24 Jun, 2026	Jill Desimone	Director	Disposed M	8,566	$0.00	$0	0	Direct
24 Jun, 2026	Jill Desimone	Director	Disposed M	3,034	$0.00	$0	0	Direct
10 Jun, 2026	Dean J Mitchell	Director	Acquired A	1,371	$0.00	$0	18,622	Direct
10 Jun, 2026	Gregory Norden	Director	Acquired A	1,371	$0.00	$0	1,559	Direct

Showing 1 to 20 of 325 transactions