Orchestra BioMed Holdings (OBIO) Change in Cash (2021 - 2026)

Orchestra BioMed Holdings (OBIO) reported Change in Cash of -$6.3 million for Q1 2026, down 61.59% year-over-year from -$16.5 million in Q1 2025, and up 13.64% on a QoQ basis from -$7.3 million in Q4 2025.

Orchestra BioMed Holdings (OBIO) has 6 years of Change in Cash data on file, last reported at -$6.3 million in Q1 2026.

  • Quarterly Change in Cash fell 61.59% year-over-year to -$6.3 million in Q1 2026, while the trailing twelve-month figure through Mar 2026 was $10.0 million (up 301.35% YoY) and the FY2025 annual result came in at $12.4 million, up 249.78% from the prior year.
  • Change in Cash advanced to -$6.3 million in Q1 2026 per OBIO's latest filing, from -$7.3 million in the prior quarter.
  • Across five years, Change in Cash topped out at $77.6 million in Q2 2022 and bottomed at -$77.2 million in Q4 2022.
  • The 5-year median for Change in Cash is -$1.1 million (2023), against an average of $1.1 million.
  • Peak annual rise in Change in Cash reached 198454.75% in 2022, while the deepest fall reached 267668.34% in 2022.
  • Tracing OBIO's Change in Cash over 5 years: stood at -$77.2 million in 2022, then surged by 114.87% to $11.5 million in 2023, then slumped by 129.13% to -$3.3 million in 2024, then sank by 118.96% to -$7.3 million in 2025, then advanced by 13.64% to -$6.3 million in 2026.
  • Per Business Quant, the three latest OBIO Change in Cash figures stand at -$6.3 million (Q1 2026), -$7.3 million (Q4 2025), and $23.3 million (Q3 2025).

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Change in Cash (Qtr)
1 Quantum Biopharma 1,216,509.61 Bn 1,216,509.61 Bn - 2.44 Mn
2 Alterity Therapeutics 764,224.41 Bn 764,224.38 Bn - -
3 Legend Biotech 2,716.00 Bn 2,715.71 Bn 242.10 Mn 623.00 Mn
4 Nanobiotix 2,248.83 Bn 2,248.77 Bn - -
5 Akari Therapeutics 1,951.18 Bn 1,951.17 Bn - -2.44 Mn
6 Vertex Pharmaceuticals 113.69 Bn 106.44 Bn 2.59 Bn 417.10 Mn
7 Evaxion A 64.16 Bn 64.14 Bn - -
8 Regeneron Pharmaceuticals 63.94 Bn 55.18 Bn 3.31 Bn -153.10 Mn
9 Alnylam Pharmaceuticals 40.13 Bn 37.12 Bn 959.66 Mn 53.61 Mn
10 Orchestra BioMed Holdings 245.24 Mn 255.02 Mn 78,000.00 -6.32 Mn

Historic Data

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DateValue
Mar 31, 2026 -6.32 Mn
Dec 31, 2025 -7.32 Mn
Sep 30, 2025 23.26 Mn
Jun 30, 2025 401,000.00
Mar 31, 2025 -3.91 Mn
Dec 31, 2024 -3.34 Mn
Sep 30, 2024 1.89 Mn
Jun 30, 2024 389,000.00
Mar 31, 2024 -7.24 Mn
Dec 31, 2023 11.48 Mn
Sep 30, 2023 2.67 Mn
Jun 30, 2023 -2.29 Mn
Mar 31, 2023 -1.09 Mn
Dec 31, 2022 -77.21 Mn
Sep 30, 2022 -9.98 Mn
Jun 30, 2022 77.64 Mn
Mar 31, 2022 19.39 Mn
Dec 31, 2021 -28,835.00
Sep 30, 2021 -128,010.00
Jun 30, 2021 -39,143.00
Mar 31, 2021 -76,374.00