Growth Metrics

Krystal Biotech (KRYS) Net Margin (2023 - 2026)

Krystal Biotech recorded quarterly Net Margin of 48.07% in Q1 2026, little changed quarter-over-quarter from 47.99% in Q4 2025, and up 755.0% year-over-year from 5.62% in Q1 2025.

Krystal Biotech's Net Margin history runs 4 years deep, the most recent figure standing at 48.07% for Q1 2026.

  • In Q1 2026, Net Margin rose 755.0% year-over-year to 48.07%; the TTM figure through Mar 2026 stood at 53.94% (up 1675.0% YoY), while the FY2025 annual figure was 52.64%, up 2195.0% from the prior year.
  • Net Margin came in at 48.07% for Q1 2026 at Krystal Biotech, roughly flat from 47.99% in the prior quarter.
  • In the past five years, Net Margin ranged from a high of 943.75% in Q3 2023 to a low of 2.06% in Q1 2024.
  • A 4-year average of 120.79% and a median of 40.52% in 2025 frame the typical range for Net Margin.
  • Across the five-year window, Net Margin tumbled 91133 bps in 2024 and jumped 4873 bps in 2025, its largest moves.
  • Krystal Biotech's Net Margin stood at 20.63% in 2023, then soared by 142 bps to 49.95% in 2024, then retreated by 4 bps to 47.99% in 2025, then gained by 0 bps to 48.07% in 2026.
  • According to Business Quant data, Net Margin over the past three periods registered 48.07%, 47.99%, and 81.15% for Q1 2026, Q4 2025, and Q3 2025 respectively.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Net Margin (Qtr)
1 Quantum Biopharma 1,216,509.61 Bn 1,216,509.61 Bn - -
2 Alterity Therapeutics 764,224.41 Bn 764,224.38 Bn - -
3 Legend Biotech 2,716.00 Bn 2,715.71 Bn 242.10 Mn 0.82%
4 Nanobiotix 2,248.83 Bn 2,248.77 Bn - -
5 Akari Therapeutics 1,951.18 Bn 1,951.17 Bn - -
6 Vertex Pharmaceuticals 113.69 Bn 106.44 Bn 2.59 Bn 34.53%
7 Evaxion A 64.16 Bn 64.14 Bn - -
8 Regeneron Pharmaceuticals 63.94 Bn 55.18 Bn 3.31 Bn 20.17%
9 Alnylam Pharmaceuticals 40.13 Bn 37.12 Bn 959.66 Mn 17.65%
10 Krystal Biotech 9.05 Bn 8.23 Bn 110.03 Mn 48.07%

Historic Data

Download Data 🔒
DateValue
Mar 31, 2026 48.07%
Dec 31, 2025 47.99%
Sep 30, 2025 81.15%
Jun 30, 2025 39.97%
Mar 31, 2025 40.52%
Dec 31, 2024 49.95%
Sep 30, 2024 32.42%
Jun 30, 2024 22.15%
Mar 31, 2024 2.06%
Dec 31, 2023 20.63%
Sep 30, 2023 943.75%