Growth Metrics

Krystal Biotech (KRYS) EBITDA Margin (2021 - 2025)

Krystal Biotech (KRYS) has disclosed EBITDA Margin for 4 consecutive years, with 48.04% as the latest value for Q4 2025.

  • Quarterly EBITDA Margin fell 1.0% to 48.04% in Q4 2025 from the year-ago period, while the trailing twelve-month figure was 52.99% through Dec 2025, up 2258.0% year-over-year, with the annual reading at 52.98% for FY2025, 2258.0% up from the prior year.
  • EBITDA Margin hit 48.04% in Q4 2025 for Krystal Biotech, down from 81.09% in the prior quarter.
  • In the past five years, EBITDA Margin ranged from a high of 1059.99% in Q1 2021 to a low of 0.01% in Q1 2024.
  • Historically, EBITDA Margin has averaged 212.8% across 4 years, with a median of 41.18% in 2025.
  • Biggest five-year swings in EBITDA Margin: plummeted -90705bps in 2024 and later skyrocketed 4610bps in 2025.
  • Year by year, EBITDA Margin stood at 1059.99% in 2021, then plummeted by -98bps to 23.04% in 2023, then skyrocketed by 108bps to 48.05% in 2024, then fell by 0bps to 48.04% in 2025.
  • Business Quant data shows EBITDA Margin for KRYS at 48.04% in Q4 2025, 81.09% in Q3 2025, and 40.73% in Q2 2025.