Growth Metrics

Krystal Biotech (KRYS) EBITDA Margin (2021 - 2025)

Krystal Biotech's EBITDA Margin history spans 4 years, with the latest figure at 48.03% for Q4 2025.

  • For Q4 2025, EBITDA Margin fell 1.0% year-over-year to 48.03%; the TTM value through Dec 2025 reached 52.98%, up 2258.0%, while the annual FY2025 figure was 52.98%, 2258.0% up from the prior year.
  • EBITDA Margin for Q4 2025 was 48.03% at Krystal Biotech, down from 81.09% in the prior quarter.
  • Across five years, EBITDA Margin topped out at 1059.99% in Q1 2021 and bottomed at 0.01% in Q1 2024.
  • The 4-year median for EBITDA Margin is 41.17% (2025), against an average of 212.8%.
  • The largest annual shift saw EBITDA Margin tumbled -90706bps in 2024 before it surged 4611bps in 2025.
  • A 4-year view of EBITDA Margin shows it stood at 1059.99% in 2021, then crashed by -98bps to 23.05% in 2023, then soared by 108bps to 48.04% in 2024, then fell by 0bps to 48.03% in 2025.
  • Per Business Quant, the three most recent readings for KRYS's EBITDA Margin are 48.03% (Q4 2025), 81.09% (Q3 2025), and 40.73% (Q2 2025).