Exelixis (EXEL) Operating Margin (2010 - 2026)
Exelixis (EXEL) posted quarterly Operating Margin of 41.15% for Q2 2026, up 751.0% year-over-year from 4.84% in Q2 2025, and up 4.73% quarter-over-quarter from 39.29% in Q1 2026.
Exelixis (EXEL) Operating Margin (2010 - 2026) Analysis & Trends
Exelixis' Operating Margin history runs 17 years deep, the most recent figure standing at 41.15% for Q2 2026.
- In Q2 2026, Operating Margin rose 751.0% year-over-year to 41.15%; the TTM figure through Apr 2026 stood at 39.43% (up 628.0% YoY), while the FY2026 annual figure was 37.59%, up 971.0% from the prior year.
- Operating Margin for Q2 2026 stood at 41.15%, up from 39.29% in the prior quarter.
- The five-year high for Operating Margin was 43.3% in Q2 2024, with the low at 11.34% in Q4 2022.
- The 5-year median for Operating Margin is 23.38% (2022), against an average of 22.62%.
- The sharpest annual moves came in 2023 and 2024: Operating Margin plunged 2379 bps in 2023, then surged 2895 bps in 2024.
- Exelixis' Operating Margin stood at 11.34% in 2022, then soared by 250 bps to 17.05% in 2023, then soared by 48 bps to 25.22% in 2024, then soared by 57 bps to 39.57% in 2025, then climbed by 4 bps to 41.15% in 2026.
- Business Quant data shows EXEL's Operating Margin at 41.15% in Q2 2026, 39.29% in Q1 2026, and 39.57% in Q4 2025.
Powered by 
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Vertex Pharmaceuticals | 128.13 Bn | 120.28 Bn | 2.84 Bn | 37.40% |
| 2 | Regeneron Pharmaceuticals | 112.33 Bn | 104.33 Bn | 3.93 Bn | 30.15% |
| 3 | Argenx Se | 53.24 Bn | 48.05 Bn | 1.41 Bn | 31.68% |
| 4 | Revolution Medicines | 43.64 Bn | 43.64 Bn | - | - |
| 5 | BeOne Medicines | 39.27 Bn | 34.17 Bn | 1.53 Bn | 19.06% |
| 6 | MindWalk Holdings | 35.32 Bn | 35.31 Bn | 1.82 Bn | -105.20% |
| 7 | Royalty Pharma | 33.72 Bn | 35.84 Bn | - | 19.75% |
| 8 | Alnylam Pharmaceuticals | 30.58 Bn | 27.27 Bn | 992.69 Mn | 17.93% |
| 9 | Insmed | 27.01 Bn | 25.85 Bn | 358.27 Mn | -0.36% |
| 10 | Exelixis | 12.75 Bn | 11.91 Bn | 608.03 Mn | 39.51% |
Historic Data
Download Data| Date | Value |
|---|---|
| Jul 3, 2026 | 39.51% |
| Apr 3, 2026 | 41.15% |
| Jan 2, 2026 | 39.29% |
| Oct 3, 2025 | 39.57% |
| Jul 4, 2025 | 37.58% |
| Apr 4, 2025 | 33.64% |
| Jan 3, 2025 | 28.80% |
| Sep 27, 2024 | 25.22% |
| Jun 28, 2024 | 43.30% |
| Mar 29, 2024 | 6.93% |
| Dec 29, 2023 | 17.05% |
| Sep 29, 2023 | -3.73% |
| Jun 30, 2023 | 16.57% |
| Mar 31, 2023 | 7.05% |
| Dec 30, 2022 | -11.34% |
| Sep 30, 2022 | 20.06% |
| Jul 1, 2022 | 19.96% |
| Apr 1, 2022 | 23.38% |
| Oct 1, 2021 | 15.72% |
| Jul 2, 2021 | 31.94% |