Denali Therapeutics (DNLI) Net Income (2017 - 2026)

Denali Therapeutics' (DNLI) quarterly Net Income came in at -$129.0 million in Q1 2026, up 5.05% year-on-year from -$122.8 million in Q1 2025, and up 1.84% on a QoQ basis from -$131.4 million in Q4 2025.

Denali Therapeutics (DNLI) Net Income (2017 - 2026) Analysis & Trends

Denali Therapeutics (DNLI) has 10 years of Net Income data on file, last reported at -$129.0 million in Q1 2026.

  • On a quarterly basis, Net Income rose 5.05% year-over-year to -$129.0 million in Q1 2026; TTM through Mar 2026 was -$562.5 million, a 20.88% decrease from a year earlier, with the FY2025 full-year figure at -$512.5 million, down 21.23% from the prior year.
  • Net Income for Q1 2026 stood at -$129.0 million, up from -$131.4 million in the prior quarter.
  • Over the last five years, Net Income for DNLI reached as high as $183.4 million in Q2 2023 and fell as low as -$172.2 million in Q2 2025.
  • Historically, Net Income has averaged -$94.7 million across 5 years, with a median of -$110.1 million in 2024.
  • Across the five-year window, Net Income surged 411.91% in 2023 and tumbled 155.56% in 2024, its largest moves.
  • Year by year, Net Income stood at -$98.7 million in 2022, then fell by 21.07% to -$119.5 million in 2023, then increased by 1.59% to -$117.6 million in 2024, then decreased by 11.79% to -$131.4 million in 2025, then rose by 1.84% to -$129.0 million in 2026.
  • Per Business Quant data, the three most recent Net Income figures were -$129.0 million in Q1 2026, -$131.4 million in Q4 2025, and -$129.9 million in Q3 2025.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Net Income (Qtr)
1 Oculis Holding AG 67,072.09 Bn 67,072.09 Bn - -37.09 Mn
2 Nanobiotix 1,894.61 Bn 1,894.55 Bn - -
3 Akari Therapeutics 1,014.18 Bn 1,014.18 Bn - -14.46 Mn
4 BeOne Medicines 471.64 Bn 466.85 Bn 1.35 Bn 227.36 Mn
5 Vertex Pharmaceuticals 121.72 Bn 114.47 Bn 2.59 Bn 1.03 Bn
6 Regeneron Pharmaceuticals 68.28 Bn 59.52 Bn 3.31 Bn 727.20 Mn
7 Belite Bio 61.40 Bn 61.40 Bn - -26.94 Mn
8 Argenx Se 56.94 Bn 56.94 Bn 1.18 Bn 498.00 Mn
9 Revolution Medicines 37.37 Bn 37.37 Bn - -453.82 Mn
10 Denali Therapeutics 4.33 Bn 4.33 Bn - -129.01 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 -129.01 Mn
Dec 31, 2025 -131.43 Mn
Sep 30, 2025 -129.88 Mn
Jun 30, 2025 -172.23 Mn
Mar 31, 2025 -135.87 Mn
Dec 31, 2024 -117.57 Mn
Sep 30, 2024 -110.08 Mn
Jun 30, 2024 -101.88 Mn
Mar 31, 2024 -104.60 Mn
Dec 31, 2023 -119.47 Mn
Sep 30, 2023 -99.35 Mn
Jun 30, 2023 183.38 Mn
Mar 31, 2023 -112.78 Mn
Dec 31, 2022 -98.68 Mn
Sep 30, 2022 -103.30 Mn
Jun 30, 2022 -58.79 Mn
Mar 31, 2022 -69.12 Mn
Dec 31, 2021 -75.26 Mn
Sep 30, 2021 -84.59 Mn
Jun 30, 2021 -60.69 Mn