Denali Therapeutics (DNLI) EBT (2017 - 2026)
Denali Therapeutics (DNLI) posted quarterly EBT of -$129.0 million for Q1 2026, up 5.05% year-over-year from -$122.8 million in Q1 2025, and up 1.84% quarter-over-quarter from -$131.4 million in Q4 2025.
Denali Therapeutics (DNLI) EBT (2017 - 2026) Analysis & Trends
Denali Therapeutics (DNLI) has reported EBT for 10 consecutive years, with -$129.0 million the latest figure, recorded in Q1 2026.
- In Q1 2026, EBT rose 5.05% year-over-year to -$129.0 million; the TTM figure through Mar 2026 stood at -$562.5 million (down 20.88% YoY), while the FY2025 annual figure was -$512.4 million, down 21.23% from the prior year.
- EBT climbed to -$129.0 million in Q1 2026 per DNLI's latest filing, from -$131.4 million in the prior quarter.
- Across five years, EBT topped out at $183.4 million in Q2 2023 and bottomed at -$172.2 million in Q2 2025.
- Historically, EBT has averaged -$94.7 million across 5 years, with a median of -$110.1 million in 2024.
- Annual changes were most pronounced in 2023 — EBT soared 412.05% — and 2024, when it sank 155.56%.
- Denali Therapeutics' EBT stood at -$98.7 million in 2022, then decreased by 21.04% to -$119.4 million in 2023, then gained by 1.57% to -$117.6 million in 2024, then fell by 11.79% to -$131.4 million in 2025, then grew by 1.84% to -$129.0 million in 2026.
- Business Quant data shows DNLI's EBT at -$129.0 million in Q1 2026, -$131.4 million in Q4 2025, and -$129.9 million in Q3 2025.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBT (Qtr) |
|---|---|---|---|---|---|
| 1 | Vertex Pharmaceuticals | 128.13 Bn | 120.28 Bn | 2.84 Bn | 1.39 Bn |
| 2 | Regeneron Pharmaceuticals | 112.33 Bn | 104.33 Bn | 3.93 Bn | 1.53 Bn |
| 3 | Argenx Se | 53.24 Bn | 48.05 Bn | 1.41 Bn | 541.00 Mn |
| 4 | Revolution Medicines | 43.64 Bn | 43.64 Bn | - | -644.37 Mn |
| 5 | BeOne Medicines | 39.27 Bn | 34.17 Bn | 1.53 Bn | 312.46 Mn |
| 6 | MindWalk Holdings | 35.32 Bn | 35.31 Bn | 1.82 Bn | -2,828.29 |
| 7 | Royalty Pharma | 33.72 Bn | 35.84 Bn | - | 81.49 Mn |
| 8 | Alnylam Pharmaceuticals | 30.58 Bn | 27.27 Bn | 992.69 Mn | 177.81 Mn |
| 9 | Insmed | 27.01 Bn | 25.85 Bn | 358.27 Mn | -11.37 Mn |
| 10 | Denali Therapeutics | 3.90 Bn | 3.90 Bn | 3.51 Mn | -130.55 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Jun 30, 2026 | -130.55 Mn |
| Mar 31, 2026 | -129.01 Mn |
| Dec 31, 2025 | -131.43 Mn |
| Sep 30, 2025 | -129.88 Mn |
| Jun 30, 2025 | -172.23 Mn |
| Mar 31, 2025 | -135.87 Mn |
| Dec 31, 2024 | -117.57 Mn |
| Sep 30, 2024 | -110.08 Mn |
| Jun 30, 2024 | -101.88 Mn |
| Mar 31, 2024 | -104.60 Mn |
| Dec 31, 2023 | -119.44 Mn |
| Sep 30, 2023 | -99.35 Mn |
| Jun 30, 2023 | 183.38 Mn |
| Mar 31, 2023 | -112.78 Mn |
| Dec 31, 2022 | -98.68 Mn |
| Sep 30, 2022 | -103.30 Mn |
| Jun 30, 2022 | -58.77 Mn |
| Mar 31, 2022 | -69.12 Mn |
| Dec 31, 2021 | -75.84 Mn |
| Sep 30, 2021 | -84.59 Mn |