Denali Therapeutics DNLI
NASDAQ DNLI
$22.27 -0.53 (-2.32%)
As of: Sep 4, 2026 · 12:48 PM EDT

Denali Therapeutics (DNLI) EBT (2017 - 2026)

Denali Therapeutics (DNLI) posted quarterly EBT of -$129.0 million for Q1 2026, up 5.05% year-over-year from -$122.8 million in Q1 2025, and up 1.84% quarter-over-quarter from -$131.4 million in Q4 2025.

Analysis

Denali Therapeutics (DNLI) EBT (2017 - 2026) Analysis & Trends

Denali Therapeutics (DNLI) has reported EBT for 10 consecutive years, with -$129.0 million the latest figure, recorded in Q1 2026.

  • In Q1 2026, EBT rose 5.05% year-over-year to -$129.0 million; the TTM figure through Mar 2026 stood at -$562.5 million (down 20.88% YoY), while the FY2025 annual figure was -$512.4 million, down 21.23% from the prior year.
  • EBT climbed to -$129.0 million in Q1 2026 per DNLI's latest filing, from -$131.4 million in the prior quarter.
  • Across five years, EBT topped out at $183.4 million in Q2 2023 and bottomed at -$172.2 million in Q2 2025.
  • Historically, EBT has averaged -$94.7 million across 5 years, with a median of -$110.1 million in 2024.
  • Annual changes were most pronounced in 2023 — EBT soared 412.05% — and 2024, when it sank 155.56%.
  • Denali Therapeutics' EBT stood at -$98.7 million in 2022, then decreased by 21.04% to -$119.4 million in 2023, then gained by 1.57% to -$117.6 million in 2024, then fell by 11.79% to -$131.4 million in 2025, then grew by 1.84% to -$129.0 million in 2026.
  • Business Quant data shows DNLI's EBT at -$129.0 million in Q1 2026, -$131.4 million in Q4 2025, and -$129.9 million in Q3 2025.
Peer Set

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) EBT (Qtr)
1 Vertex Pharmaceuticals 139.76 Bn 131.91 Bn 2.84 Bn 1.39 Bn
2 Regeneron Pharmaceuticals 85.72 Bn 77.72 Bn 3.93 Bn 1.53 Bn
3 Argenx Se 63.56 Bn 58.38 Bn 1.37 Bn 542.00 Mn
4 Moderna 57.87 Bn 52.73 Bn 52.00 Mn -767.00 Mn
5 Revolution Medicines 44.06 Bn 44.06 Bn - -644.37 Mn
6 BeOne Medicines 40.08 Bn 34.98 Bn 1.53 Bn 312.46 Mn
7 Alnylam Pharmaceuticals 35.50 Bn 32.20 Bn 992.69 Mn 177.81 Mn
8 Royalty Pharma 28.54 Bn 27.70 Bn - 81.49 Mn
9 Insmed 27.49 Bn 26.33 Bn 358.27 Mn -11.37 Mn
10 Denali Therapeutics 4.17 Bn 4.17 Bn 3.51 Mn -127.55 Mn
Historic Data

Historic Data

Download Data
DateValue
Jun 30, 2026 -127.55 Mn
Mar 31, 2026 -128.45 Mn
Dec 31, 2025 -128.45 Mn
Sep 30, 2025 -126.90 Mn
Jun 30, 2025 -124.12 Mn
Mar 31, 2025 -132.97 Mn
Dec 31, 2024 -114.69 Mn
Sep 30, 2024 -107.19 Mn
Jun 30, 2024 -99.03 Mn
Mar 31, 2024 -101.80 Mn
Dec 31, 2023 -119.44 Mn
Sep 30, 2023 -99.35 Mn
Jun 30, 2023 183.38 Mn
Mar 31, 2023 -109.78 Mn
Dec 31, 2022 -98.68 Mn
Sep 30, 2022 -103.30 Mn
Jun 30, 2022 -58.77 Mn
Mar 31, 2022 -66.50 Mn
Dec 31, 2021 -75.84 Mn
Sep 30, 2021 -84.59 Mn