Denali Therapeutics (DNLI) EBIT (2017 - 2026)
Denali Therapeutics' (DNLI) quarterly EBIT came in at -$137.4 million in Q1 2026, up 5.65% year-on-year from -$130.0 million in Q1 2025, and little changed on a QoQ basis from -$137.4 million in Q4 2025.
Denali Therapeutics (DNLI) EBIT (2017 - 2026) Analysis & Trends
Denali Therapeutics (DNLI) has 10 years of EBIT data on file, last reported at -$137.4 million in Q1 2026.
- On a quarterly basis, EBIT rose 5.65% year-over-year to -$137.4 million in Q1 2026; TTM through Mar 2026 was -$547.1 million, a 6.19% decrease from a year earlier, with the FY2025 full-year figure at -$555.3 million, down 13.95% from the prior year.
- EBIT for Q1 2026 stood at -$137.4 million, roughly flat from -$137.4 million in the prior quarter.
- Over the last five years, EBIT for DNLI reached as high as $170.5 million in Q2 2023 and fell as low as -$145.6 million in Q1 2025.
- Historically, EBIT has averaged -$101.0 million across 5 years, with a median of -$120.8 million in 2023.
- Across the five-year window, EBIT surged 377.59% in 2023 and plunged 168.39% in 2024, its largest moves.
- Year by year, EBIT stood at -$105.3 million in 2022, then dropped by 25.85% to -$132.6 million in 2023, then rose by 2.06% to -$129.8 million in 2024, then decreased by 5.79% to -$137.4 million in 2025, then increased by 0.01% to -$137.4 million in 2026.
- Per Business Quant data, the three most recent EBIT figures were -$137.4 million in Q1 2026, -$137.4 million in Q4 2025, and -$137.4 million in Q3 2025.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBIT (Qtr) |
|---|---|---|---|---|---|
| 1 | Oculis Holding AG | 67,072.09 Bn | 67,072.09 Bn | - | -27.75 Mn |
| 2 | Nanobiotix | 1,894.61 Bn | 1,894.55 Bn | - | - |
| 3 | Akari Therapeutics | 1,014.18 Bn | 1,014.18 Bn | - | -15.76 Mn |
| 4 | BeOne Medicines | 471.64 Bn | 466.85 Bn | 1.35 Bn | 249.90 Mn |
| 5 | Vertex Pharmaceuticals | 121.72 Bn | 114.47 Bn | 2.59 Bn | 1.14 Bn |
| 6 | Regeneron Pharmaceuticals | 68.28 Bn | 59.52 Bn | 3.31 Bn | 642.90 Mn |
| 7 | Belite Bio | 61.40 Bn | 61.40 Bn | - | -32.68 Mn |
| 8 | Argenx Se | 56.94 Bn | 56.94 Bn | 1.18 Bn | 394.00 Mn |
| 9 | Revolution Medicines | 37.37 Bn | 37.37 Bn | - | -445.22 Mn |
| 10 | Denali Therapeutics | 4.33 Bn | 4.33 Bn | - | -137.36 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -137.36 Mn |
| Dec 31, 2025 | -137.37 Mn |
| Sep 30, 2025 | -137.43 Mn |
| Jun 30, 2025 | -134.96 Mn |
| Mar 31, 2025 | -145.58 Mn |
| Dec 31, 2024 | -129.85 Mn |
| Sep 30, 2024 | -123.19 Mn |
| Jun 30, 2024 | -116.59 Mn |
| Mar 31, 2024 | -117.72 Mn |
| Dec 31, 2023 | -132.57 Mn |
| Sep 30, 2023 | -113.80 Mn |
| Jun 30, 2023 | 170.48 Mn |
| Mar 31, 2023 | -120.82 Mn |
| Dec 31, 2022 | -105.34 Mn |
| Sep 30, 2022 | -107.49 Mn |
| Jun 30, 2022 | -61.42 Mn |
| Mar 31, 2022 | -66.50 Mn |
| Dec 31, 2021 | -77.12 Mn |
| Sep 30, 2021 | -85.59 Mn |
| Jun 30, 2021 | -61.82 Mn |