Cue Biopharma (CUE) Return on Capital Employed (2018 - 2025)

Cue Biopharma's (CUE) quarterly Return on Capital Employed came in at 23.38% in Q4 2025, up 1103.0% year-on-year from 1.94% in Q4 2024, and up 7.18% quarter-over-quarter from 25.19% in Q3 2025.

Cue Biopharma (CUE) Return on Capital Employed (2018 - 2025) Analysis & Trends

Cue Biopharma has disclosed Return on Capital Employed across 8 years of filings, most recently posting 23.38% for Q4 2025.

  • Return on Capital Employed for Q4 2025 came in at 23.38%, up 1103.0% year-over-year; the trailing twelve-month figure through Dec 2025 was 23.38% (up 1103.0% YoY), and the FY2025 annual result was 23.12%, up 263.0% from the prior year.
  • Return on Capital Employed came in at 23.38% for Q4 2025 at Cue Biopharma, up from 25.19% in the prior quarter.
  • In the past five years, Return on Capital Employed ranged from a high of 23.38% in Q4 2025 to a low of 170.65% in Q3 2024.
  • The 5-year median for Return on Capital Employed is 66.86% (2021), against an average of 76.7%.
  • Across the five-year window, Return on Capital Employed plunged 7183 bps in 2024 and surged 14545 bps in 2025, its largest moves.
  • Cue Biopharma's Return on Capital Employed stood at 63.98% in 2021, then decreased by 15 bps to 73.67% in 2022, then plunged by 47 bps to 108.35% in 2023, then surged by 68 bps to 34.42% in 2024, then soared by 32 bps to 23.38% in 2025.
  • The last three Return on Capital Employed figures came in at 23.38% (Q4 2025), 25.19% (Q3 2025), and 52.53% (Q2 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) ROCE (Qtr)
1 Alterity Therapeutics 925,601.88 Bn 925,601.85 Bn - -
2 Belite Bio 58,560.00 Bn 58,560.00 Bn - -
3 Quantum Biopharma 17,284.41 Bn 17,284.40 Bn - 450.31%
4 Legend Biotech 2,809.00 Bn 2,808.71 Bn 242.10 Mn 51.73%
5 Evaxion A 1,334.43 Bn 1,334.42 Bn - -
6 Akari Therapeutics 1,312.27 Bn 1,312.26 Bn - -107.40%
7 Psyence Biomedical 212.16 Bn 212.16 Bn - -
8 Vertex Pharmaceuticals 114.83 Bn 107.58 Bn 2.59 Bn 21.10%
9 Abivax 91.96 Bn 91.96 Bn - -50.43%
10 Cue Biopharma 581.16 Mn 553.47 Mn - -23.38%

Historic Data

Download Data
DateValue
Dec 31, 2025 -23.38%
Sep 30, 2025 -25.19%
Jun 30, 2025 -52.53%
Mar 31, 2025 -69.69%
Dec 31, 2024 -34.42%
Sep 30, 2024 -170.65%
Jun 30, 2024 -152.46%
Mar 31, 2024 -129.72%
Dec 31, 2023 -108.35%
Sep 30, 2023 -98.82%
Jun 30, 2023 -86.38%
Mar 31, 2023 -72.06%
Dec 31, 2022 -73.67%
Sep 30, 2022 -65.79%
Jun 30, 2022 -60.75%
Mar 31, 2022 -60.09%
Dec 31, 2021 -63.98%
Sep 30, 2021 -67.93%
Jun 30, 2021 -60.57%
Mar 31, 2021 -57.51%