CASI Pharmaceuticals (CASIF) EBITDA (2022 - 2025)
CASI Pharmaceuticals (CASIF) reported EBITDA of -$77.2 million for Q4 2025, down 218.78% on a YoY basis from $65.0 million in Q4 2024, and down 607.28% quarter-over-quarter from -$10.9 million in Q3 2025.
CASI Pharmaceuticals (CASIF) EBITDA (2022 - 2025) Analysis & Trends
CASI Pharmaceuticals has reported EBITDA for 4 years, with the latest figure at -$77.2 million in Q4 2025.
- For the quarter ending Q4 2025, EBITDA fell 218.78% year-over-year to -$77.2 million; the trailing twelve-month figure through Dec 2025 stood at -$112.7 million (down 292.0% YoY), and the FY2025 full-year result was -$45.0 million, down 212.99% from the prior year.
- EBITDA for Q4 2025 stood at -$77.2 million, down from -$10.9 million in the prior quarter.
- The five-year high for EBITDA was $65.0 million in Q4 2024, with the low at -$77.2 million in Q4 2025.
- Historically, EBITDA has averaged -$4.5 million across 4 years, with a median of -$8.3 million in 2022.
- Annual changes were most pronounced in 2023 — EBITDA jumped 386.19% — and 2025, when it tumbled 218.79%.
- CASI Pharmaceuticals' EBITDA stood at -$17.4 million in 2022, then jumped by 386.19% to $49.9 million in 2023, then jumped by 30.25% to $65.0 million in 2024, then slumped by 218.78% to -$77.2 million in 2025.
- The last three EBITDA figures came in at -$77.2 million (Q4 2025), -$10.9 million (Q3 2025), and -$13.4 million (Q2 2025), per Business Quant data.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBITDA (Qtr) |
|---|---|---|---|---|---|
| 1 | Alterity Therapeutics | 821,726.73 Bn | 821,726.69 Bn | - | - |
| 2 | Belite Bio | 57,768.00 Bn | 57,768.00 Bn | - | -26.92 Mn |
| 3 | Quantum Biopharma | 16,655.88 Bn | 16,655.88 Bn | - | -13.63 Mn |
| 4 | Legend Biotech | 3,540.00 Bn | 3,539.71 Bn | 242.10 Mn | -19.70 Mn |
| 5 | Evaxion A | 1,526.26 Bn | 1,526.24 Bn | - | -3.82 Mn |
| 6 | Akari Therapeutics | 1,520.09 Bn | 1,520.09 Bn | - | -14.44 Mn |
| 7 | Psyence Biomedical | 223.87 Bn | 223.87 Bn | - | -752,618.00 |
| 8 | Vertex Pharmaceuticals | 114.47 Bn | 107.23 Bn | 2.59 Bn | 1.14 Bn |
| 9 | Abivax | 91.22 Bn | 91.22 Bn | - | -65.83 Mn |
| 10 | CASI Pharmaceuticals | - | - | 3.69 Mn | -77.19 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | -77.19 Mn |
| Sep 30, 2025 | -10.91 Mn |
| Jun 30, 2025 | -13.39 Mn |
| Mar 31, 2025 | -11.20 Mn |
| Dec 31, 2024 | 64.99 Mn |
| Sep 30, 2024 | -8.44 Mn |
| Jun 30, 2024 | -7.28 Mn |
| Mar 31, 2024 | 9.43 Mn |
| Dec 31, 2023 | 49.89 Mn |
| Sep 30, 2023 | -4.64 Mn |
| Jun 30, 2023 | -12.25 Mn |
| Mar 31, 2023 | -5.63 Mn |
| Dec 31, 2022 | -17.43 Mn |
| Sep 30, 2022 | -8.15 Mn |
| Jun 30, 2022 | -11.03 Mn |
| Mar 31, 2022 | -8.15 Mn |