Growth Metrics

BioNTech SE (BNTX) EBITDA (2018 - 2025)

BioNTech SE (BNTX) posted EBITDA of -$375.8 million for Q4 2025, down 585.32% on a QoQ basis from -$54.8 million in Q3 2025, and down 336.63% year-over-year from $158.8 million in Q4 2024.

BioNTech SE (BNTX) has 8 years of EBITDA data on file, last reported at -$375.8 million in Q4 2025.

  • In Q4 2025, EBITDA fell 336.63% year-over-year to -$375.8 million; the TTM figure through Dec 2025 stood at -$1.4 billion (down 50.58% YoY), while the FY2025 annual figure was -$1.6 billion, down 13.02% from the prior year.
  • EBITDA declined to -$375.8 million in Q4 2025, from -$54.8 million in the prior quarter.
  • Across five years, EBITDA topped out at $5.6 billion in Q3 2021 and bottomed at -$985.8 million in Q2 2024.
  • A 5-year average of $1.5 billion and a median of $385.7 million in 2024 frame the typical range for EBITDA.
  • Annual changes were most pronounced in 2021 — EBITDA surged 5574.02% — and 2025, when it sank 336.63%.
  • Year by year, EBITDA stood at $5.4 billion in 2021, then tumbled by 37.51% to $3.4 billion in 2022, then slumped by 83.15% to $566.2 million in 2023, then sank by 71.95% to $158.8 million in 2024, then slumped by 336.63% to -$375.8 million in 2025.
  • The last three EBITDA figures came in at -$375.8 million (Q4 2025), -$54.8 million (Q3 2025), and -$481.1 million (Q2 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) EBITDA (Qtr)
1 Quantum Biopharma 961,148.99 Bn 961,148.98 Bn - -13.63 Mn
2 Alterity Therapeutics 744,933.29 Bn 744,933.26 Bn - -
3 Legend Biotech 2,540.00 Bn 2,539.71 Bn 242.10 Mn -19.70 Mn
4 Nanobiotix 2,199.85 Bn 2,199.78 Bn - -
5 Akari Therapeutics 1,635.88 Bn 1,635.88 Bn - -14.44 Mn
6 Vertex Pharmaceuticals 111.32 Bn 104.07 Bn 2.59 Bn 1.14 Bn
7 Evaxion A 62.56 Bn 62.54 Bn - -3.82 Mn
8 Regeneron Pharmaceuticals 62.55 Bn 53.79 Bn 3.31 Bn 661.60 Mn
9 Alnylam Pharmaceuticals 39.57 Bn 36.56 Bn 959.66 Mn 201.19 Mn
10 BioNTech SE 27.66 Bn 7.53 Bn 668.28 Mn -375.75 Mn

Historic Data

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DateValue
Dec 31, 2025 -375.75 Mn
Sep 30, 2025 -54.83 Mn
Jun 30, 2025 -481.08 Mn
Mar 31, 2025 -503.64 Mn
Dec 31, 2024 158.79 Mn
Sep 30, 2024 205.15 Mn
Jun 30, 2024 -985.78 Mn
Mar 31, 2024 -318.09 Mn
Dec 31, 2023 566.16 Mn
Sep 30, 2023 165.47 Mn
Jun 30, 2023 -613.39 Mn
Mar 31, 2023 702.39 Mn
Dec 31, 2022 3.36 Bn
Sep 30, 2022 2.41 Bn
Jun 30, 2022 2.36 Bn
Mar 31, 2022 5.33 Bn
Dec 31, 2021 5.38 Bn
Sep 30, 2021 5.57 Bn
Jun 30, 2021 5.06 Bn
Mar 31, 2021 2.01 Bn
Dec 31, 2020 291,157.18 Bn
Sep 30, 2020 217.73 Mn
Jun 30, 2020 89.11 Mn
Mar 31, 2020 65.46 Mn
Dec 31, 2019 -343.22 Mn
Sep 30, 2019 41.03 Mn
Jun 30, 2019 53.79 Mn
Mar 31, 2019 49.82 Mn
Dec 31, 2018 61,410.03
Sep 30, 2018 25.16