BioNTech SE (BNTX) Gross Margin (2018 - 2025)
BioNTech SE (BNTX) posted Gross Margin of 63.27% for Q4 2025, down 29.89% on a QoQ basis from 90.24% in Q3 2025, and down 1627.0% year-over-year from 4.14% in Q4 2024.
BioNTech SE (BNTX) has 8 years of Gross Margin data on file, last reported at 63.27% in Q4 2025.
- In Q4 2025, Gross Margin fell 1627.0% year-over-year to 63.27%; the TTM figure through Dec 2025 stood at 77.83% (down 183.0% YoY), while the FY2025 annual figure was 77.64%, up 48830.0% from the prior year.
- Gross Margin retreated to 63.27% in Q4 2025, from 90.24% in the prior quarter.
- Across five years, Gross Margin topped out at 100.0% in Q4 2021 and bottomed at 82.32% in Q2 2024.
- A 5-year average of 69.7% and a median of 80.81% in 2022 frame the typical range for Gross Margin.
- Annual changes were most pronounced in 2024 — Gross Margin slumped 8518 bps — and 2025, when it jumped 15302 bps.
- Year by year, Gross Margin stood at 100.0% in 2021, then dropped by 4 bps to 95.71% in 2022, then dropped by 8 bps to 87.89% in 2023, then decreased by 10 bps to 79.54% in 2024, then fell by 20 bps to 63.27% in 2025.
- The last three Gross Margin figures came in at 63.27% (Q4 2025), 90.24% (Q3 2025), and 70.71% (Q2 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Gross Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Quantum Biopharma | 961,148.99 Bn | 961,148.98 Bn | - | - |
| 2 | Alterity Therapeutics | 744,933.29 Bn | 744,933.26 Bn | - | - |
| 3 | Legend Biotech | 2,540.00 Bn | 2,539.71 Bn | 242.10 Mn | 79.04% |
| 4 | Nanobiotix | 2,199.85 Bn | 2,199.78 Bn | - | - |
| 5 | Akari Therapeutics | 1,635.88 Bn | 1,635.88 Bn | - | - |
| 6 | Vertex Pharmaceuticals | 111.32 Bn | 104.07 Bn | 2.59 Bn | 86.85% |
| 7 | Evaxion A | 62.56 Bn | 62.54 Bn | - | - |
| 8 | Regeneron Pharmaceuticals | 62.55 Bn | 53.79 Bn | 3.31 Bn | 91.79% |
| 9 | Alnylam Pharmaceuticals | 39.57 Bn | 36.56 Bn | 959.66 Mn | 82.22% |
| 10 | BioNTech SE | 27.66 Bn | 7.53 Bn | 668.28 Mn | 63.27% |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | 63.27% |
| Sep 30, 2025 | 90.24% |
| Jun 30, 2025 | 70.71% |
| Mar 31, 2025 | -261.21% |
| Dec 31, 2024 | -7,278.79% |
| Sep 30, 2024 | 85.63% |
| Jun 30, 2024 | -82.32% |
| Mar 31, 2024 | -542.39% |
| Dec 31, 2023 | 87.89% |
| Sep 30, 2023 | 81.93% |
| Jun 30, 2023 | 2.86% |
| Mar 31, 2023 | 92.48% |
| Dec 31, 2022 | 95.71% |
| Sep 30, 2022 | 78.25% |
| Jun 30, 2022 | 76.08% |
| Mar 31, 2022 | 79.70% |
| Dec 31, 2021 | 89.46% |
| Sep 30, 2021 | 100.00% |
| Jun 30, 2021 | 83.35% |
| Mar 31, 2021 | 88.62% |
| Dec 31, 2020 | 88.13% |
| Sep 30, 2020 | 89.80% |
| Jun 30, 2020 | 86.44% |
| Mar 31, 2020 | 78.78% |
| Sep 30, 2019 | 85.24% |
| Jun 30, 2019 | 78.71% |
| Mar 31, 2019 | 87.75% |
| Dec 31, 2018 | 92.98% |
| Sep 30, 2018 | 86.38% |