BioNTech SE (BNTX) Gross Margin (2018 - 2025)
BioNTech SE (BNTX) posted Gross Margin of 63.27% for Q4 2025, down 29.89% sequentially from 90.24% in Q3 2025, and down 3672.0% YoY from 1.77% in Q4 2024.
BioNTech SE (BNTX) Gross Margin (2018 - 2025) Analysis & Trends
BioNTech SE has reported Gross Margin for 8 years, with the latest figure at 63.27% in Q4 2025.
- Quarterly Gross Margin fell 3672.0% year-over-year to 63.27% in Q4 2025, while the trailing twelve-month figure through Dec 2025 was 77.83% (down 2216.0% YoY) and the FY2025 annual result came in at 77.64%, down 269.0% from the prior year.
- Gross Margin retreated to 63.27% in Q4 2025 per BNTX's latest filing, from 90.24% in the prior quarter.
- Over five years, Gross Margin peaked at 100.0% in Q3 2021 and troughed at 2.86% in Q2 2023.
- A 5-year average of 77.12% and a median of 82.64% in 2023 frame the typical range for Gross Margin.
- The sharpest annual moves came in 2023 and 2024: Gross Margin tumbled 7322 bps in 2023, then surged 5067 bps in 2024.
- Over 5 years, Gross Margin stood at 89.46% in 2021, then gained by 7 bps to 95.71% in 2022, then slipped by 8 bps to 87.89% in 2023, then gained by 14 bps to 99.99% in 2024, then slumped by 37 bps to 63.27% in 2025.
- According to Business Quant data, Gross Margin over the past three periods registered 63.27%, 90.24%, and 70.71% for Q4 2025, Q3 2025, and Q2 2025 respectively.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Gross Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Vertex Pharmaceuticals | 128.13 Bn | 120.28 Bn | 2.84 Bn | 85.33% |
| 2 | Regeneron Pharmaceuticals | 112.33 Bn | 104.33 Bn | 3.93 Bn | 91.59% |
| 3 | Argenx Se | 53.24 Bn | 48.05 Bn | 1.41 Bn | 90.68% |
| 4 | Revolution Medicines | 43.64 Bn | 43.64 Bn | - | - |
| 5 | BeOne Medicines | 39.27 Bn | 34.17 Bn | 1.53 Bn | 89.76% |
| 6 | MindWalk Holdings | 35.32 Bn | 35.31 Bn | 1.82 Bn | 60,631,834.75% |
| 7 | Royalty Pharma | 33.72 Bn | 35.84 Bn | - | - |
| 8 | Alnylam Pharmaceuticals | 30.58 Bn | 27.27 Bn | 992.69 Mn | 76.90% |
| 9 | Insmed | 27.01 Bn | 25.85 Bn | 358.27 Mn | 84.20% |
| 10 | BioNTech SE | 23.54 Bn | 5.15 Bn | 668.28 Mn | 63.27% |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | 63.27% |
| Sep 30, 2025 | 90.24% |
| Jun 30, 2025 | 70.71% |
| Mar 31, 2025 | 54.16% |
| Dec 31, 2024 | 79.54% |
| Sep 30, 2024 | 85.63% |
| Jun 30, 2024 | 53.54% |
| Mar 31, 2024 | 68.50% |
| Dec 31, 2023 | 87.89% |
| Sep 30, 2023 | 81.93% |
| Jun 30, 2023 | 2.86% |
| Mar 31, 2023 | 92.48% |
| Dec 31, 2022 | 95.71% |
| Sep 30, 2022 | 78.25% |
| Jun 30, 2022 | 76.08% |
| Mar 31, 2022 | 79.70% |
| Dec 31, 2021 | 89.46% |
| Sep 30, 2021 | 80.10% |
| Jun 30, 2021 | 83.35% |
| Mar 31, 2021 | 88.62% |