Biofrontera (BFRI) Gross Margin (2020 - 2025)
Biofrontera (BFRI) recorded quarterly Gross Margin of 82.4% in Q4 2025, up 16.5% quarter-over-quarter from 70.74% in Q3 2025, and up 2437.0% on a YoY basis from 3.25% in Q4 2024.
Biofrontera (BFRI) Gross Margin (2020 - 2025) Analysis & Trends
Biofrontera's Gross Margin history runs 6 years deep, the most recent figure standing at 82.4% for Q4 2025.
- In Q4 2025, Gross Margin rose 2437.0% year-over-year to 82.4%; the TTM figure through Dec 2025 stood at 73.71% (up 2356.0% YoY), while the FY2025 annual figure was 73.71%, up 2357.0% from the prior year.
- Gross Margin was 82.4% for Q4 2025 at Biofrontera, up from 70.74% in the prior quarter.
- In the past five years, Gross Margin ranged from a high of 112.8% in Q4 2023 to a low of 72.27% in Q4 2022.
- Historically, Gross Margin has averaged 67.81% across 5 years, with a median of 70.74% in 2025.
- The sharpest annual moves came in 2022 and 2023: Gross Margin slumped 17030 bps in 2022, then jumped 18507 bps in 2023.
- A 5-year view of Gross Margin shows it stood at 98.03% in 2021, then sank by 174 bps to 72.27% in 2022, then surged by 256 bps to 112.8% in 2023, then sank by 49 bps to 58.03% in 2024, then jumped by 42 bps to 82.4% in 2025.
- The last three Gross Margin figures came in at 82.4% (Q4 2025), 70.74% (Q3 2025), and 70.74% (Q2 2025), per Business Quant data.
Powered by 
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Gross Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Teva Pharmaceutical Industries | 39.72 Bn | 35.98 Bn | 1.97 Bn | 49.52% |
| 2 | Zoetis | 34.61 Bn | 32.67 Bn | 1.62 Bn | 71.66% |
| 3 | United Therapeutics | 24.07 Bn | 21.91 Bn | 648.10 Mn | 82.93% |
| 4 | Aurora Cannabis | 16.98 Bn | 16.91 Bn | 33.43 Mn | 49.50% |
| 5 | Neurocrine Biosciences | 16.64 Bn | 15.32 Bn | 800.70 Mn | 98.31% |
| 6 | Elanco Animal Health | 12.19 Bn | 11.76 Bn | 785.00 Mn | 57.26% |
| 7 | Alkermes | 7.37 Bn | 6.86 Bn | -116.06 Mn | -293.83% |
| 8 | Hims & Hers Health | 6.62 Bn | 5.87 Bn | 396.79 Mn | 65.25% |
| 9 | Lantheus Holdings | 6.47 Bn | 5.97 Bn | 230.92 Mn | 61.20% |
| 10 | Biofrontera | 8.65 Mn | 2.24 Mn | 14.09 Mn | 82.40% |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | 82.40% |
| Sep 30, 2025 | 70.74% |
| Jun 30, 2025 | 70.74% |
| Mar 31, 2025 | 61.95% |
| Dec 31, 2024 | 58.03% |
| Sep 30, 2024 | 45.88% |
| Jun 30, 2024 | 44.61% |
| Mar 31, 2024 | 47.98% |
| Dec 31, 2023 | 112.80% |
| Sep 30, 2023 | 49.47% |
| Jun 30, 2023 | 52.60% |
| Mar 31, 2023 | 47.33% |
| Dec 31, 2022 | -72.27% |
| Sep 30, 2022 | 97.73% |
| Jun 30, 2022 | 96.59% |
| Mar 31, 2022 | 98.21% |
| Dec 31, 2021 | 98.03% |
| Sep 30, 2021 | 99.05% |
| Jun 30, 2021 | 97.69% |
| Mar 31, 2021 | 96.56% |