Avalo Therapeutics (AVTX) Return on Sales (2016 - 2025)
Avalo Therapeutics' (AVTX) quarterly Return on Sales came in at 2.33% in Q4 2025, down 48.0% YoY from 4.47% in Q4 2024, and down 2.68% on a QoQ basis from 2.26% in Q3 2025.
Avalo Therapeutics (AVTX) Return on Sales (2016 - 2025) Analysis & Trends
Avalo Therapeutics (AVTX) has 10 years of Return on Sales data on file, last reported at 2.33% in Q4 2025.
- Quarterly Return on Sales fell 48.0% year-over-year to 2.33% in Q4 2025, while the trailing twelve-month figure through Dec 2025 was 1.57% (down 77.0% YoY) and the FY2025 annual result came in at 13.26%, down 1247.0% from the prior year.
- Return on Sales retreated to 2.33% in Q4 2025, from 2.26% in the prior quarter.
- In the past five years, Return on Sales ranged from a high of 0.93% in Q3 2024 to a low of 2.33% in Q4 2025.
- A 5-year average of 0.45% and a median of 0.13% in 2023 frame the typical range for Return on Sales.
- Annual changes were most pronounced in 2024 — Return on Sales jumped 115 bps — and 2025, when it tumbled 319 bps.
- Tracing AVTX's Return on Sales over 5 years: stood at 0.0% in 2021, then surged by 99 bps to 0.0% in 2022, then sank by 382254 bps to 0.14% in 2023, then slumped by 1187 bps to 1.84% in 2024, then decreased by 26 bps to 2.33% in 2025.
- The last three Return on Sales figures came in at 2.33% (Q4 2025), 2.26% (Q3 2025), and 1.84% (Q4 2024), per Business Quant data.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROS (Qtr) |
|---|---|---|---|---|---|
| 1 | Vertex Pharmaceuticals | 128.13 Bn | 120.28 Bn | 2.84 Bn | 0.00% |
| 2 | Regeneron Pharmaceuticals | 112.33 Bn | 104.33 Bn | 3.93 Bn | 0.00% |
| 3 | Argenx Se | 53.24 Bn | 48.05 Bn | 1.41 Bn | 0.00% |
| 4 | Revolution Medicines | 43.64 Bn | 43.64 Bn | - | - |
| 5 | BeOne Medicines | 39.27 Bn | 34.17 Bn | 1.53 Bn | 0.00% |
| 6 | MindWalk Holdings | 35.32 Bn | 35.31 Bn | 1.82 Bn | 0.00% |
| 7 | Royalty Pharma | 33.72 Bn | 35.84 Bn | - | 0.00% |
| 8 | Alnylam Pharmaceuticals | 30.58 Bn | 27.27 Bn | 992.69 Mn | 0.00% |
| 9 | Insmed | 27.01 Bn | 25.85 Bn | 358.27 Mn | 0.00% |
| 10 | Avalo Therapeutics | 854.16 Mn | 453.89 Mn | - | - |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | -2.33% |
| Sep 30, 2025 | -2.26% |
| Dec 31, 2024 | -1.84% |
| Sep 30, 2024 | 0.93% |
| Jun 30, 2024 | -0.45% |
| Mar 31, 2024 | -0.99% |
| Dec 31, 2023 | -0.14% |
| Sep 30, 2023 | -0.22% |
| Jun 30, 2023 | -0.13% |
| Mar 31, 2023 | -0.21% |
| Sep 30, 2022 | 0.00% |
| Jun 30, 2022 | 0.00% |
| Mar 31, 2022 | 0.00% |
| Dec 31, 2021 | 0.00% |
| Sep 30, 2021 | 0.00% |
| Jun 30, 2021 | 0.00% |
| Mar 31, 2021 | 0.00% |
| Dec 31, 2020 | 0.00% |
| Sep 30, 2020 | 0.00% |
| Jun 30, 2020 | 0.00% |