Avalo Therapeutics (AVTX) Return on Sales (2016 - 2025)

Avalo Therapeutics posted quarterly Return on Sales of 2.33% for Q4 2025, down 48.0% year-on-year from 4.47% in Q4 2024, and down 2.68% on a QoQ basis from 2.26% in Q3 2025.

Avalo Therapeutics (AVTX) has 10 years of Return on Sales data on file, last reported at 2.33% in Q4 2025.

  • For the quarter ending Q4 2025, Return on Sales fell 48.0% year-over-year to 2.33%; the trailing twelve-month figure through Dec 2025 stood at 1.57% (down 77.0% YoY), and the FY2025 full-year result was 13.26%, down 1247.0% from the prior year.
  • Return on Sales for Q4 2025 stood at 2.33%, down from 2.26% in the prior quarter.
  • Across five years, Return on Sales topped out at 0.93% in Q3 2024 and bottomed at 2.33% in Q4 2025.
  • The 5-year median for Return on Sales is 0.13% (2023), against an average of 0.45%.
  • The widest annual swing landed in 2024, when Return on Sales jumped 115 bps; it then sank 319 bps in 2025.
  • A 5-year view of Return on Sales shows it stood at 0.0% in 2021, then soared by 99 bps to 0.0% in 2022, then plunged by 382254 bps to 0.14% in 2023, then sank by 1187 bps to 1.84% in 2024, then slipped by 26 bps to 2.33% in 2025.
  • The last three Return on Sales figures came in at 2.33% (Q4 2025), 2.26% (Q3 2025), and 1.84% (Q4 2024), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) ROS (Qtr)
1 Quantum Biopharma 961,148.99 Bn 961,148.98 Bn - -
2 Alterity Therapeutics 744,933.29 Bn 744,933.26 Bn - -
3 Legend Biotech 2,540.00 Bn 2,539.71 Bn 242.10 Mn 0.00%
4 Nanobiotix 2,199.85 Bn 2,199.78 Bn - -
5 Akari Therapeutics 1,635.88 Bn 1,635.88 Bn - -
6 Vertex Pharmaceuticals 111.32 Bn 104.07 Bn 2.59 Bn 0.00%
7 Evaxion A 62.56 Bn 62.54 Bn - 0.00%
8 Regeneron Pharmaceuticals 62.55 Bn 53.79 Bn 3.31 Bn 0.00%
9 Alnylam Pharmaceuticals 39.57 Bn 36.56 Bn 959.66 Mn 0.00%
10 Avalo Therapeutics 317.29 Mn 317.29 Mn - -

Historic Data

Download Data 🔒
DateValue
Dec 31, 2025 -2.33%
Sep 30, 2025 -2.26%
Dec 31, 2024 -1.84%
Sep 30, 2024 0.93%
Jun 30, 2024 -0.45%
Mar 31, 2024 -0.99%
Dec 31, 2023 -0.14%
Sep 30, 2023 -0.22%
Jun 30, 2023 -0.13%
Mar 31, 2023 -0.21%
Sep 30, 2022 0.00%
Jun 30, 2022 0.00%
Mar 31, 2022 0.00%
Dec 31, 2021 0.00%
Sep 30, 2021 0.00%
Jun 30, 2021 0.00%
Mar 31, 2021 0.00%
Dec 31, 2020 0.00%
Sep 30, 2020 0.00%
Jun 30, 2020 0.00%
Mar 31, 2020 0.00%
Dec 31, 2019 0.12%
Sep 30, 2019 0.00%
Jun 30, 2019 -0.03%
Mar 31, 2019 -0.01%
Dec 31, 2018 0.00%
Sep 30, 2018 -0.06%
Jun 30, 2018 -0.01%
Mar 31, 2018 -0.01%
Dec 31, 2017 -0.02%
Sep 30, 2017 0.01%
Jun 30, 2017 -0.11%
Mar 31, 2017 -0.05%
Dec 31, 2016 -0.09%
Sep 30, 2016 -0.19%
Jun 30, 2016 -0.06%