Growth Metrics

Alnylam Pharmaceuticals (ALNY) EBITDA Margin (2009 - 2026)

Alnylam Pharmaceuticals posted quarterly EBITDA Margin of 17.24% for Q1 2026, up 8807.0% year-on-year from 0.19% in Q1 2025, and up 67.02% on a QoQ basis from 10.32% in Q4 2025.

Alnylam Pharmaceuticals (ALNY) has 18 years of EBITDA Margin data on file, last reported at 17.24% in Q1 2026.

  • For the quarter ending Q1 2026, EBITDA Margin rose 8807.0% year-over-year to 17.24%; the trailing twelve-month figure through Mar 2026 stood at 12.01% (up 2552.0% YoY), and the FY2025 full-year result was 8.84%, up 2170.0% from the prior year.
  • EBITDA Margin for Q1 2026 stood at 17.24%, up from 10.32% in the prior quarter.
  • Across five years, EBITDA Margin topped out at 20.76% in Q3 2025 and bottomed at 154.17% in Q3 2022.
  • The 5-year median for EBITDA Margin is 20.31% (2024), against an average of 40.49%.
  • The widest annual swing landed in 2023, when EBITDA Margin jumped 17449 bps; it then sank 5676 bps in 2025.
  • A 5-year view of EBITDA Margin shows it stood at 62.19% in 2022, then jumped by 53 bps to 29.32% in 2023, then surged by 46 bps to 15.76% in 2024, then soared by 166 bps to 10.32% in 2025, then jumped by 67 bps to 17.24% in 2026.
  • The last three EBITDA Margin figures came in at 17.24% (Q1 2026), 10.32% (Q4 2025), and 20.76% (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) EBITDA Margin (Qtr)
1 Quantum Biopharma 961,148.99 Bn 961,148.98 Bn - -
2 Alterity Therapeutics 744,933.29 Bn 744,933.26 Bn - -
3 Legend Biotech 2,540.00 Bn 2,539.71 Bn 242.10 Mn -6.43%
4 Nanobiotix 2,199.85 Bn 2,199.78 Bn - -
5 Akari Therapeutics 1,635.88 Bn 1,635.88 Bn - -
6 Vertex Pharmaceuticals 111.32 Bn 104.07 Bn 2.59 Bn 38.10%
7 Evaxion A 62.56 Bn 62.54 Bn - -
8 Regeneron Pharmaceuticals 62.55 Bn 53.79 Bn 3.31 Bn 18.35%
9 Alnylam Pharmaceuticals 39.57 Bn 36.56 Bn 959.66 Mn 17.24%
10 Revolution Medicines 32.39 Bn 32.39 Bn - -

Historic Data

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DateValue
Mar 31, 2026 17.24%
Dec 31, 2025 10.32%
Sep 30, 2025 20.76%
Jun 30, 2025 -7.59%
Mar 31, 2025 -70.83%
Dec 31, 2024 -15.76%
Sep 30, 2024 -20.31%
Jun 30, 2024 -3.72%
Mar 31, 2024 -14.07%
Dec 31, 2023 -29.32%
Sep 30, 2023 20.32%
Jun 30, 2023 -85.95%
Mar 31, 2023 -52.80%
Dec 31, 2022 -62.19%
Sep 30, 2022 -154.17%
Jun 30, 2022 -125.24%
Mar 31, 2022 -114.95%
Dec 31, 2021 -99.60%
Sep 30, 2021 -108.01%
Jun 30, 2021 -85.66%
Mar 31, 2021 -108.91%
Dec 31, 2020 -152.83%
Sep 30, 2020 -204.42%
Jun 30, 2020 -173.51%
Mar 31, 2020 -178.70%
Dec 31, 2019 -388.29%
Sep 30, 2019 -295.56%
Jun 30, 2019 -497.52%
Mar 31, 2019 -545.31%
Dec 31, 2018 -1,004.43%
Sep 30, 2018 -11,835.04%
Jun 30, 2018 -543.40%
Mar 31, 2018 -646.76%
Dec 31, 2017 -376.86%
Sep 30, 2017 -717.82%
Jun 30, 2017 -744.11%
Mar 31, 2017 -567.92%
Dec 31, 2016 -679.48%
Sep 30, 2016 -758.57%
Jun 30, 2016 -1,256.33%
Mar 31, 2016 -1,584.13%
Dec 31, 2015 -1,047.98%
Sep 30, 2015 -1,625.13%
Jun 30, 2015 -1,213.66%
Mar 31, 2015 -254.38%
Dec 31, 2014 50.74%
Sep 30, 2014 -462.87%
Jun 30, 2014 -645.94%
Mar 31, 2014 -2,968.34%
Dec 31, 2013 -367.00%
Sep 30, 2013 -340.87%
Jun 30, 2013 -125.01%
Mar 31, 2013 -20.67%
Dec 31, 2012 -548.96%
Sep 30, 2012 -115.35%
Jun 30, 2012 -62.16%
Mar 31, 2012 -54.60%
Dec 31, 2011 -69.99%
Sep 30, 2011 -63.21%
Jun 30, 2011 -68.17%
Mar 31, 2011 -81.43%
Dec 31, 2010 -35.41%
Sep 30, 2010 -34.80%
Jun 30, 2010 -53.23%
Mar 31, 2010 -49.73%
Dec 31, 2009 -33.67%
Sep 30, 2009 -36.87%
Jun 30, 2009 -88.22%