Agios Pharmaceuticals (AGIO) Operating Margin (2012 - 2026)
Agios Pharmaceuticals (AGIO) posted Operating Margin of -247.07% for Q2 2026, up 773.05 percentage points from -1020.12% a year earlier and up 283.27 percentage points from the prior quarter.
Agios Pharmaceuticals (AGIO) Operating Margin (2012 - 2026) Analysis & Trends
For the trailing twelve months through Jun 30, 2026, Operating Margin at Agios Pharmaceuticals was -466.78%, up 662.35 percentage points year-over-year; for FY2025, it came in at -873.87%, up 292.60 percentage points from FY2024.
- Annual Operating Margin has increased for three consecutive years, with a three-year change of +1858.21 percentage points (FY2022 to FY2025).
- In prior years, Agios Pharmaceuticals' Operating Margin was -1166.47% in FY2024 (+293.05 pp), -1459.52% in FY2023 (+1272.55 pp) and -2732.07% in FY2022.
- The Q2 2026 figure stands as the highest quarterly Operating Margin since Q4 2020.
- On a year-over-year basis, Operating Margin has increased in each of the last five quarters, with an average year-over-year change of +364.85 percentage points over the last eight quarters.
- The strongest year-over-year quarter for Operating Margin in the past five years was Q1 2023, with a gain of 10541.36 percentage points; the weakest was Q1 2025, with a drop of 97.63 percentage points.
- According to Business Quant data, Operating Margin for the three prior quarters was -530.34% (Q1 2026), -608.89% (Q4 2025) and -907.37% (Q3 2025).
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 655.56 Bn | 574.09 Bn | 17.26 Bn | 28.21% |
| 2 | AbbVie | 470.94 Bn | 444.10 Bn | 12.70 Bn | 37.86% |
| 3 | Merck | 367.14 Bn | 321.57 Bn | 12.21 Bn | -3.52% |
| 4 | Novartis Ag | 280.33 Bn | 236.20 Bn | 11.24 Bn | 32.97% |
| 5 | Astrazeneca | 257.78 Bn | 231.34 Bn | 12.86 Bn | 20.57% |
| 6 | Amgen | 226.04 Bn | 181.44 Bn | 7.24 Bn | 34.95% |
| 7 | Gilead Sciences | 188.89 Bn | 163.01 Bn | 6.22 Bn | -133.21% |
| 8 | Pfizer | 163.75 Bn | 110.70 Bn | 10.94 Bn | 28.37% |
| 9 | Vertex Pharmaceuticals | 133.68 Bn | 105.69 Bn | 2.84 Bn | 37.40% |
| 10 | Agios Pharmaceuticals | 1.99 Bn | 1.99 Bn | 41.75 Mn | -247.07% |
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -247.07% |
| Mar 31, 2026 | -530.34% |
| Dec 31, 2025 | -608.89% |
| Sep 30, 2025 | -907.37% |
| Jun 30, 2025 | -1,020.12% |
| Mar 31, 2025 | -1,221.97% |
| Dec 31, 2024 | -1,165.30% |
| Sep 30, 2024 | -1,146.93% |
| Jun 30, 2024 | -1,228.29% |
| Mar 31, 2024 | -1,124.34% |
| Dec 31, 2023 | -1,496.23% |
| Sep 30, 2023 | -1,363.66% |
| Jun 30, 2023 | -1,396.01% |
| Mar 31, 2023 | -1,615.49% |
| Dec 31, 2022 | -2,300.97% |
| Sep 30, 2022 | -2,590.73% |
| Jun 30, 2022 | -1,749.19% |
| Mar 31, 2022 | -12,156.85% |
| Dec 31, 2020 | -209.86% |
| Sep 30, 2020 | -231.34% |
Agios Pharmaceuticals Operating Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=operating-margin&ticker=AGIO&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "operating-margin", "ticker": "AGIO", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=operating-margin&ticker=AGIO&period=max&api_key=YOUR_API_KEY");
const data = await res.json();