TSHA vs SLBT vs LEGN Stock Comparison

Taysha Gene Therapies, SL Science Holding and Legend Biotech Prices as of Nov 3, 2026 Peers: Industry group
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LEGN Legend Biotech Corp
$21.48 +15.7% 1M -33.1% 1Y
Market cap
$4.23B
P/E
–
Revenue (TTM)
$1.27B
Div. yield
–
Gene and Cell Therapy Healthcare
6 wins

Head to Head

8 decided of 12

Legend Biotech leads on 6 of the 12 questions below (Legend Biotech 6, Taysha Gene Therapies 2). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionTSHASLBTLEGNLeader
Larger companyMarket capitalisation $1.61B $2.59B $4.23B LEGN
Cheaper on earningsLower P/E, profitable companies only -10.7x — -46.2x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — — — –
Faster revenue growthRevenue growth, trailing twelve months -32.3% — +59.5% LEGN
More profitableNet margin, trailing twelve months -2,728.0% — -7.2% LEGN
Better return on capitalReturn on invested capital — — -4.2% –
Less leveragedLower net debt / EBITDA 2.7x — -130.2x LEGN
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months -8.3% -88.3% -33.1% TSHA
Better 5-year returnAnnualised price return, 5 years -24.1%/yr — -15.1%/yr LEGN
Less volatileAnnualised volatility, 1 year 70.8% 175.7% 72.4% TSHA
Higher overall scoreMean of the five percentile scores vs peers 48/100 — 74/100 LEGN

Percentile Scorecard

TSHASLBTLEGN

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisTSHASLBTLEGN
Valuation 46 #340 of 634 12 #561 of 634 88 #75 of 634
Growth 16 #508 of 607 – 97 #20 of 607
Profitability 26 #410 of 557 – 80 #112 of 557
Financial Health 76 #161 of 654 58 #278 of 654 60 #262 of 654
Shareholder Returns 78 #91 of 401 – 44 #227 of 401
Overall 48 – 74
  • TSHA ranked among 671 companies in Pharmaceuticals and Biotechnology
  • SLBT ranked among 671 companies in Pharmaceuticals and Biotechnology
  • LEGN ranked among 671 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodTSHASLBTLEGNSPY
1 month -11.7%-22.3%+15.7% -2.0%
3 months -34.0%-60.4%+12.3% -2.2%
6 months -41.1%-85.6%-24.7% +4.2%
Year to date -25.6%-88.4%-1.2% +10.6%
1 year -8.3%-88.3%-33.1% +10.4%
3 years +64.9%—-67.4% +73.6%
3 years, per year +18.2%—-31.2% +20.2%
5 years -74.9%—-55.9% +61.6%
5 years, per year -24.1%—-15.1% +10.1%

Risk

MeasureTSHASLBTLEGNSPY
Volatility, 1Y 70.8%175.7%72.4% 12.8%
Downside volatility, 1Y 68.1%169.4%62.7% 12.8%
Beta vs S&P 500, 1Y 1.830.170.48 1.00
Return / volatility, 1Y -0.12-0.50-0.46 0.81
Max drawdown, 5Y -96.4%-91.0%-78.2% -25.4%
From 52-week high -41.4%-90.5%-40.8% -3.2%
52-week high $6.98$12.81$36.28 $779.14
52-week low $3.51$1.15$16.65 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleTSHASLBTLEGN
P/E now vs peer median -10.1xmedian 18.4x —median 18.4x -43.2xmedian 18.4x
P/S now vs peer median 242.6xmedian 9.0x —median 9.0x 3.1xmedian 9.0x
EV/EBITDA now vs peer median -6.1xmedian 16.0x —median 16.0x 867.8xmedian 16.0x
P/FCF now vs peer median -10.0xmedian 21.8x -1,417xmedian 21.8x -61.3xmedian 21.8x
P/B now vs peer median 3.4xmedian 2.1x 381.5xmedian 2.1x 3.2xmedian 2.1x
PEG now vs peer median -0.25median 0.37 —median 0.37 -0.92median 0.37

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsTSHASLBTLEGN
Revenue $5.49M – $1.27B
Gross profit – – $727.10M
Operating income -$153.16M – -$55.25M
Net income -$149.63M – -$80.39M
Free cash flow -$132.57M – -$64.60M
R&D $123.14M – $396.15M
EPS (diluted) $-0.41 – $-0.50
Cash & equivalents $455.41M $8.31M $672.90M
Total debt $49.26M – $156.40M
Shares (diluted) 369.04M – 184.32M
Enterprise value $256.22M $2.58B $1.73B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricTSHASLBTLEGN
P/E -10.1x – -43.2x
P/FCF -10.0x -1,417x -61.3x
P/Operating cash flow -10.1x – -44.3x
P/S 242.6x – 3.1x
P/B 3.4x 381.5x 3.2x
P/Tangible book 3.4x 381.5x 3.2x
EV/EBITDA -6.1x – 867.8x
EV/EBIT -6.0x – -62.3x
EV/Revenue 168.5x – 2.7x
EV/FCF -7.0x – -53.3x
EV/Operating cash flow -7.0x – -38.5x
PEG (3Y EPS CAGR) -0.25 – -0.92

Growth

14 metrics
MetricTSHASLBTLEGN
Revenue growth (1Y) -32.3% – 59.5%
Revenue CAGR (3Y) -9.1% – 97.6%
Gross profit growth (1Y) – – 42.4%
Gross profit CAGR (3Y) – – 147.5%
Operating income growth (1Y) -62.9% – 75.3%
Operating income CAGR (3Y) -8.7% – 49.1%
Net income growth (1Y) -61.4% – 75.3%
Net income CAGR (3Y) -6.5% – 46.7%
EPS growth (1Y) -30.3% – 72.0%
EPS CAGR (3Y) 40.5% – 47.0%
Operating cash flow growth (1Y) -61.0% – 67.5%
Operating cash flow CAGR (3Y) -35.6% – 37.1%
Free cash flow growth (1Y) -60.6% – 77.8%
Free cash flow CAGR (3Y) -29.4% – 44.5%

Profitability

14 metrics
MetricTSHASLBTLEGN
Gross margin – – 57.2%
EBITDA margin -2,770% – 0.3%
Operating margin -2,792% – -4.3%
Pretax margin -2,593% – -4.4%
Net margin -2,728% – -7.2%
FCF margin -2,417% – -5.1%
Operating cash flow margin -2,410% – -7.0%
Return on equity -47.5% – -8.3%
Return on assets -36.9% – -5.5%
Return on invested capital – – -4.2%
Return on capital employed -42.6% – -4.3%
Asset turnover 0.0x – 0.8x
Cash conversion (OCF / net income) 0.9x – 1.1x
Stock comp / revenue 331.3% – 5.2%

Financial Health

11 metrics
MetricTSHASLBTLEGN
Debt / assets 10.5% – 8.9%
Debt / equity 0.1x – 0.1x
Net debt / EBITDA 2.7x – -130.2x
Debt / FCF -0.4x – -2.4x
Liabilities / assets 17.7% 21.8% 29.8%
Equity / assets 82.3% 78.2% 70.2%
Interest coverage -3,647x – -4.8x
Current ratio 17.8x 4.4x 3.0x
Quick ratio 17.5x 4.3x 1.7x
Cash ratio 17.5x 4.3x 1.7x
Altman Z-score 7.26 – 6.73

Shareholder Returns

7 metrics
MetricTSHASLBTLEGN
Dividend yield – – –
Net buyback yield -0.2% – -5.4%
Shareholder yield -0.2% 0.0% -5.4%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusTSHASLBTLEGN
EPS, next fiscal year $-0.47FY2026 – $-0.04FY2026
Revenue, next fiscal year $1.96MFY2026 – $1.37BFY2026
Revenue growth, next FY -80.0%FY2026 – +32.9%FY2026
Revenue growth, the year after +1,298.6% – +35.9%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersTSHASLBTLEGN
Held by institutions 81.2% – 55.9%
Institutions holding 209 – 218
Change in shares held, QoQ +12.7% – +7.3%
Institutions buying 140 – 117
Institutions selling 42 – 78
Buyers to sellers 3.33 – 1.50

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

TSHASLBTLEGN
TSHA 1.00 -0.03 0.17
SLBT -0.03 1.00 -0.03
LEGN 0.17 -0.03 1.00

Add a Peer

Largest companies in the same industry

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Frequently Asked Questions

Which is bigger, TSHA, SLBT and LEGN?

Legend Biotech (LEGN) is the largest by market capitalisation: Taysha Gene Therapies (TSHA) $1.61B, SL Science Holding (SLBT) $2.59B, Legend Biotech (LEGN) $4.23B.

Which company is growing faster?

Legend Biotech (LEGN) grew revenue fastest over the trailing twelve months: Taysha Gene Therapies (TSHA) -32.3%, Legend Biotech (LEGN) +59.5%.

Which company is more profitable?

Legend Biotech (LEGN) has the highest net margin (Taysha Gene Therapies (TSHA) -2,728.0%, Legend Biotech (LEGN) -7.2%).

Which stock has performed better?

Over the past year Taysha Gene Therapies (TSHA) returned the most: Taysha Gene Therapies (TSHA) -8.3%, SL Science Holding (SLBT) -88.3%, Legend Biotech (LEGN) -33.1%. Over five years, Legend Biotech (LEGN) compounded fastest (Taysha Gene Therapies (TSHA) -24.1%/yr, Legend Biotech (LEGN) -15.1%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Taysha Gene Therapies (TSHA) has been the steadiest (Taysha Gene Therapies (TSHA) 70.8%, SL Science Holding (SLBT) 175.7%, Legend Biotech (LEGN) 72.4%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, TSHA, SLBT and LEGN?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Legend Biotech (LEGN) leads on 6. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.