TSHA vs CRSP vs VCEL Stock Comparison

Taysha Gene Therapies, CRISPR Therapeutics AG and Vericel Prices as of Oct 27, 2026 Peers: Industry group
CRSP CRISPR Therapeutics AG
$51.47 -5.1% 1M -21.7% 1Y
Market cap
$4.98B
P/E
–
Revenue (TTM)
$13.39M
Div. yield
–
Gene and Cell Therapy Healthcare
1 win
VCEL Vericel Corp
$43.27 +9.0% 1M +18.6% 1Y
Market cap
$2.21B
P/E
91.2x
Revenue (TTM)
$306.30M
Div. yield
–
Gene and Cell Therapy Healthcare
6 wins

Head to Head

8 decided of 12

Vericel leads on 6 of the 12 questions below (Vericel 6, CRISPR Therapeutics AG 1, Taysha Gene Therapies 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionTSHACRSPVCELLeader
Larger companyMarket capitalisation $1.38B $4.98B $2.21B CRSP
Cheaper on earningsLower P/E, profitable companies only -10.5x -11.0x 91.2x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — — 84.8x –
Faster revenue growthRevenue growth, trailing twelve months -32.3% -64.8% +23.0% VCEL
More profitableNet margin, trailing twelve months -2,728.0% -3,368.7% 7.9% VCEL
Better return on capitalReturn on invested capital — -22.6% — –
Less leveragedLower net debt / EBITDA 2.7x 3.4x — TSHA
Higher dividend yieldTrailing dividend yield — — — –
Better 1-year returnPrice return, last 12 months -12.9% -21.7% +18.6% VCEL
Better 5-year returnAnnualised price return, 5 years -23.5%/yr -11.4%/yr -3.3%/yr VCEL
Less volatileAnnualised volatility, 1 year 71.6% 57.2% 40.8% VCEL
Higher overall scoreMean of the five percentile scores vs peers 49/100 44/100 81/100 VCEL

Percentile Scorecard

TSHACRSPVCEL

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisTSHACRSPVCEL
Valuation 45 #346 of 625 49 #322 of 625 82 #116 of 625
Growth 16 #506 of 602 32 #411 of 602 94 #38 of 602
Profitability 28 #397 of 551 32 #375 of 551 88 #66 of 551
Financial Health 76 #159 of 656 71 #190 of 656 69 #207 of 656
Shareholder Returns 78 #80 of 365 38 #228 of 365 73 #99 of 365
Overall 49 44 81
  • TSHA ranked among 672 companies in Pharmaceuticals and Biotechnology
  • CRSP ranked among 672 companies in Pharmaceuticals and Biotechnology
  • VCEL ranked among 672 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodTSHACRSPVCELSPY
1 month -9.0%-5.1%+9.0% -0.2%
3 months -22.2%+8.2%-7.4% +3.9%
6 months -32.5%-1.1%+21.4% +8.2%
Year to date -22.7%-1.8%+20.2% +12.9%
1 year -12.9%-21.7%+18.6% +12.3%
3 years +92.3%+32.9%+31.8% +87.4%
3 years, per year +24.4%+9.9%+9.7% +23.3%
5 years -73.8%-45.2%-15.3% +67.9%
5 years, per year -23.5%-11.4%-3.3% +10.9%
10 years —+225.3%+1,781.3% +261.1%
10 years, per year —+12.5%+34.1% +13.7%

Risk

MeasureTSHACRSPVCELSPY
Volatility, 1Y 71.6%57.2%40.8% 12.7%
Downside volatility, 1Y 70.1%53.7%40.1% 12.7%
Beta vs S&P 500, 1Y 1.831.830.74 1.00
Return / volatility, 1Y -0.18-0.380.46 0.97
Max drawdown, 5Y -96.5%-67.7%-65.4% -25.4%
From 52-week high -39.1%-21.7%-10.4% -1.2%
52-week high $6.98$65.72$48.31 $779.14
52-week low $3.51$44.34$29.34 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleTSHACRSPVCEL
P/E now vs peer median -10.5xmedian 17.2x -11.0xmedian 17.2x 91.2xmedian 17.2x
P/S now vs peer median 252.1xmedian 9.0x 371.5xmedian 9.0x 7.2xmedian 9.0x
EV/EBITDA now vs peer median -6.4xmedian 16.3x -6.2xmedian 16.3x 65.4xmedian 16.3x
P/FCF now vs peer median -10.4xmedian 18.7x -13.4xmedian 18.7x 35.9xmedian 18.7x
P/B now vs peer median 3.6xmedian 2.2x 2.8xmedian 2.2x 6.0xmedian 2.2x
PEG now vs peer median -0.26median 0.33 -2.86median 0.33 1.68median 0.33

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsTSHACRSPVCEL
Revenue $5.49M $13.39M $306.30M
Gross profit – – $228.38M
Operating income -$153.16M -$534.34M $18.24M
Net income -$149.63M -$451.14M $24.22M
Free cash flow -$132.57M -$371.33M $61.66M
R&D $123.14M $278.15M $29.17M
EPS (diluted) $-0.41 $-4.67 $0.46
Cash & equivalents $455.41M $291.34M $125.40M
Total debt $49.26M $586.20M –
Shares (diluted) 369.04M 96.51M 52.31M
Enterprise value $33.42M -$3.72B $1.63B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricTSHACRSPVCEL
P/E -10.5x -11.0x 91.2x
P/FCF -10.4x -13.4x 35.9x
P/Operating cash flow -10.5x -13.5x 31.8x
P/S 252.1x 371.5x 7.2x
P/B 3.6x 2.8x 6.0x
P/Tangible book 3.6x 2.8x 6.1x
EV/EBITDA -6.4x -6.2x 65.4x
EV/EBIT -6.4x -6.0x 112.5x
EV/Revenue 178.0x 238.7x 6.7x
EV/FCF -7.4x -8.6x 33.3x
EV/Operating cash flow -7.4x -8.7x 29.4x
PEG (3Y EPS CAGR) -0.26 -2.86 1.68

Growth

14 metrics
MetricTSHACRSPVCEL
Revenue growth (1Y) -32.3% -64.8% 23.0%
Revenue CAGR (3Y) -9.1% -57.1% 19.8%
Gross profit growth (1Y) – – 24.8%
Gross profit CAGR (3Y) – – 23.9%
Operating income growth (1Y) -62.9% 3.3% 1,428%
Operating income CAGR (3Y) -8.7% -4.1% 47.8%
Net income growth (1Y) -61.4% 3.6% 240.8%
Net income CAGR (3Y) -6.5% -2.7% 56.6%
EPS growth (1Y) -30.3% 13.0% 228.1%
EPS CAGR (3Y) 40.5% 3.9% 54.3%
Operating cash flow growth (1Y) -61.0% -13.8% 47.5%
Operating cash flow CAGR (3Y) -35.6% -2.5% 33.7%
Free cash flow growth (1Y) -60.6% -14.1% 842.9%
Free cash flow CAGR (3Y) -29.4% -0.9% 43.2%

Profitability

14 metrics
MetricTSHACRSPVCEL
Gross margin – – 74.6%
EBITDA margin -2,770% -3,850% 10.2%
Operating margin -2,792% -3,990% 6.0%
Pretax margin -2,593% -3,346% 8.2%
Net margin -2,728% -3,369% 7.9%
FCF margin -2,417% -2,773% 20.1%
Operating cash flow margin -2,410% -2,760% 22.7%
Return on equity -47.5% -25.3% 6.9%
Return on assets -36.9% -16.8% 5.1%
Return on invested capital – -22.6% –
Return on capital employed -42.6% -20.9% 4.1%
Asset turnover 0.0x 0.0x 0.6x
Cash conversion (OCF / net income) 0.9x 0.8x 2.9x
Stock comp / revenue 331.3% 510.2% 12.2%

Financial Health

11 metrics
MetricTSHACRSPVCEL
Debt / assets 10.5% 22.1% –
Debt / equity 0.1x 0.3x –
Net debt / EBITDA 2.7x 3.4x –
Debt / FCF -0.4x -1.6x –
Liabilities / assets 17.7% 34.1% 26.4%
Equity / assets 82.3% 65.9% 73.6%
Interest coverage -3,647x – 28.5x
Current ratio 17.8x 17.8x 5.0x
Quick ratio 17.5x 17.8x 4.5x
Cash ratio 17.5x 17.8x 3.1x
Altman Z-score 7.64 2.51 10.18

Shareholder Returns

7 metrics
MetricTSHACRSPVCEL
Dividend yield – – –
Net buyback yield -0.2% -8.6% -0.3%
Shareholder yield -0.2% -8.6% -0.3%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusTSHACRSPVCEL
Forward P/E – – 84.8xFY2026
EPS, next fiscal year $-0.47FY2026 $-4.10FY2026 $0.51FY2026
EPS growth, next FY – – +59.4%FY2026
EPS growth, the year after – – +74.5%
Revenue, next fiscal year $1.96MFY2026 $38.73MFY2026 $324.56MFY2026
Revenue growth, next FY -80.0%FY2026 +1,003.4%FY2026 +17.5%FY2026
Revenue growth, the year after +1,298.6% +266.1% +16.1%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersTSHACRSPVCEL
Held by institutions 81.2% 78.9% 100.0%
Institutions holding 209 518 317
Change in shares held, QoQ +12.7% -1.0% +0.4%
Institutions buying 140 237 187
Institutions selling 42 139 98
Buyers to sellers 3.33 1.71 1.91

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

TSHACRSPVCEL
TSHA 1.00 0.44 0.17
CRSP 0.44 1.00 0.35
VCEL 0.17 0.35 1.00

Add a Peer

Largest companies in the same industry

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Frequently Asked Questions

Which is bigger, TSHA, CRSP and VCEL?

CRISPR Therapeutics AG (CRSP) is the largest by market capitalisation: Taysha Gene Therapies (TSHA) $1.38B, CRISPR Therapeutics AG (CRSP) $4.98B, Vericel (VCEL) $2.21B.

Which company is growing faster?

Vericel (VCEL) grew revenue fastest over the trailing twelve months: Taysha Gene Therapies (TSHA) -32.3%, CRISPR Therapeutics AG (CRSP) -64.8%, Vericel (VCEL) +23.0%.

Which company is more profitable?

Vericel (VCEL) has the highest net margin (Taysha Gene Therapies (TSHA) -2,728.0%, CRISPR Therapeutics AG (CRSP) -3,368.7%, Vericel (VCEL) 7.9%).

Which stock has performed better?

Over the past year Vericel (VCEL) returned the most: Taysha Gene Therapies (TSHA) -12.9%, CRISPR Therapeutics AG (CRSP) -21.7%, Vericel (VCEL) +18.6%. Over five years, Vericel (VCEL) compounded fastest (Taysha Gene Therapies (TSHA) -23.5%/yr, CRISPR Therapeutics AG (CRSP) -11.4%/yr, Vericel (VCEL) -3.3%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Vericel (VCEL) has been the steadiest (Taysha Gene Therapies (TSHA) 71.6%, CRISPR Therapeutics AG (CRSP) 57.2%, Vericel (VCEL) 40.8%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, TSHA, CRSP and VCEL?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Vericel (VCEL) leads on 6. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.