TSHA vs SLBT Stock Comparison

Taysha Gene Therapies and SL Science Holding Prices as of Oct 27, 2026 Peers: Industry group
SLBT SL Science Holding Ltd
$1.19 -24.2% 1M -88.5% 1Y
Market cap
$2.59B
P/E
–
Revenue (TTM)
—
Div. yield
–
Gene and Cell Therapy Healthcare
1 win

Head to Head

3 decided of 12

Taysha Gene Therapies leads on 2 of the 12 questions below (Taysha Gene Therapies 2, SL Science Holding 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionTSHASLBTLeader
Larger companyMarket capitalisation $1.38B $2.59B SLBT
Cheaper on earningsLower P/E, profitable companies only -10.5x — –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — — –
Faster revenue growthRevenue growth, trailing twelve months -32.3% — –
More profitableNet margin, trailing twelve months -2,728.0% — –
Better return on capitalReturn on invested capital — — –
Less leveragedLower net debt / EBITDA 2.7x — –
Higher dividend yieldTrailing dividend yield — 0.00% –
Better 1-year returnPrice return, last 12 months -12.9% -88.5% TSHA
Better 5-year returnAnnualised price return, 5 years -23.5%/yr — –
Less volatileAnnualised volatility, 1 year 71.6% 175.4% TSHA
Higher overall scoreMean of the five percentile scores vs peers 49/100 — –

Percentile Scorecard

TSHASLBT

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisTSHASLBT
Valuation 45 #346 of 625 11 #555 of 625
Growth 16 #506 of 602 –
Profitability 28 #397 of 551 –
Financial Health 76 #159 of 656 58 #279 of 656
Shareholder Returns 78 #80 of 365 –
Overall 49 –
  • TSHA ranked among 672 companies in Pharmaceuticals and Biotechnology
  • SLBT ranked among 672 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodTSHASLBTSPY
1 month -9.0%-24.2% -0.2%
3 months -22.2%-56.7% +3.9%
6 months -32.5%-84.9% +8.2%
Year to date -22.7%-88.7% +12.9%
1 year -12.9%-88.5% +12.3%
3 years +92.3%— +87.4%
3 years, per year +24.4%— +23.3%
5 years -73.8%— +67.9%
5 years, per year -23.5%— +10.9%

Risk

MeasureTSHASLBTSPY
Volatility, 1Y 71.6%175.4% 12.7%
Downside volatility, 1Y 70.1%170.6% 12.7%
Beta vs S&P 500, 1Y 1.830.23 1.00
Return / volatility, 1Y -0.18-0.50 0.97
Max drawdown, 5Y -96.5%-91.0% -25.4%
From 52-week high -39.1%-90.7% -1.2%
52-week high $6.98$12.81 $779.14
52-week low $3.51$1.15 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleTSHASLBT
P/E now vs peer median -10.5xmedian 17.2x —median 17.2x
P/S now vs peer median 252.1xmedian 9.0x —median 9.0x
EV/EBITDA now vs peer median -6.4xmedian 16.3x —median 16.3x
P/FCF now vs peer median -10.4xmedian 18.7x -1,382xmedian 18.7x
P/B now vs peer median 3.6xmedian 2.2x 372.2xmedian 2.2x
PEG now vs peer median -0.26median 0.33 —median 0.33

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsTSHASLBT
Revenue $5.49M –
Operating income -$153.16M –
Net income -$149.63M –
Free cash flow -$132.57M –
R&D $123.14M –
EPS (diluted) $-0.41 –
Cash & equivalents $455.41M $8.31M
Total debt $49.26M –
Shares (diluted) 369.04M –
Enterprise value $33.42M $2.58B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricTSHASLBT
P/E -10.5x –
P/FCF -10.4x -1,382x
P/Operating cash flow -10.5x –
P/S 252.1x –
P/B 3.6x 372.2x
P/Tangible book 3.6x 372.2x
EV/EBITDA -6.4x –
EV/EBIT -6.4x –
EV/Revenue 178.0x –
EV/FCF -7.4x –
EV/Operating cash flow -7.4x –
PEG (3Y EPS CAGR) -0.26 –

Growth

14 metrics
MetricTSHASLBT
Revenue growth (1Y) -32.3% –
Revenue CAGR (3Y) -9.1% –
Gross profit growth (1Y) – –
Gross profit CAGR (3Y) – –
Operating income growth (1Y) -62.9% –
Operating income CAGR (3Y) -8.7% –
Net income growth (1Y) -61.4% –
Net income CAGR (3Y) -6.5% –
EPS growth (1Y) -30.3% –
EPS CAGR (3Y) 40.5% –
Operating cash flow growth (1Y) -61.0% –
Operating cash flow CAGR (3Y) -35.6% –
Free cash flow growth (1Y) -60.6% –
Free cash flow CAGR (3Y) -29.4% –

Profitability

14 metrics
MetricTSHASLBT
Gross margin – –
EBITDA margin -2,770% –
Operating margin -2,792% –
Pretax margin -2,593% –
Net margin -2,728% –
FCF margin -2,417% –
Operating cash flow margin -2,410% –
Return on equity -47.5% –
Return on assets -36.9% –
Return on invested capital – –
Return on capital employed -42.6% –
Asset turnover 0.0x –
Cash conversion (OCF / net income) 0.9x –
Stock comp / revenue 331.3% –

Financial Health

11 metrics
MetricTSHASLBT
Debt / assets 10.5% –
Debt / equity 0.1x –
Net debt / EBITDA 2.7x –
Debt / FCF -0.4x –
Liabilities / assets 17.7% 21.8%
Equity / assets 82.3% 78.2%
Interest coverage -3,647x –
Current ratio 17.8x 4.4x
Quick ratio 17.5x 4.3x
Cash ratio 17.5x 4.3x
Altman Z-score 7.64 –

Shareholder Returns

7 metrics
MetricTSHASLBT
Dividend yield – –
Net buyback yield -0.2% –
Shareholder yield -0.2% 0.0%
Payout ratio (earnings) – –
Payout ratio (FCF) – –
Dividend growth (1Y) – –
Dividend CAGR (3Y) – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusTSHASLBT
EPS, next fiscal year $-0.47FY2026 –
Revenue, next fiscal year $1.96MFY2026 –
Revenue growth, next FY -80.0%FY2026 –
Revenue growth, the year after +1,298.6% –

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersTSHASLBT
Held by institutions 81.2% –
Institutions holding 209 –
Change in shares held, QoQ +12.7% –
Institutions buying 140 –
Institutions selling 42 –
Buyers to sellers 3.33 –

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

TSHASLBT
TSHA 1.00 -0.03
SLBT -0.03 1.00

Add a Peer

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Frequently Asked Questions

Which is bigger, TSHA and SLBT?

SL Science Holding (SLBT) is the largest by market capitalisation: Taysha Gene Therapies (TSHA) $1.38B, SL Science Holding (SLBT) $2.59B.

Which stock has performed better?

Over the past year Taysha Gene Therapies (TSHA) returned the most: Taysha Gene Therapies (TSHA) -12.9%, SL Science Holding (SLBT) -88.5%. Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Taysha Gene Therapies (TSHA) has been the steadiest (Taysha Gene Therapies (TSHA) 71.6%, SL Science Holding (SLBT) 175.4%). Volatility measures how widely the price swings, not the risk of the business.

Do TSHA and SLBT move together?

Their daily returns over the past year have a correlation of -0.03, a negative relationship. Holding both diversifies more than two closely linked stocks would.

Which is the better stock, TSHA and SLBT?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Taysha Gene Therapies (TSHA) leads on 2. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.