TSHA vs BEAM vs CRSP Stock Comparison

Taysha Gene Therapies, Beam Therapeutics and CRISPR Therapeutics AG Prices as of Nov 3, 2026 Peers: Industry group
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BEAM Beam Therapeutics Inc.
$26.33 +7.5% 1M +8.6% 1Y
Market cap
$2.88B
P/E
–
Revenue (TTM)
$156.04M
Div. yield
–
Gene and Cell Therapy Healthcare
4 wins
CRSP CRISPR Therapeutics AG
$49.99 -9.8% 1M -19.3% 1Y
Market cap
$5.00B
P/E
–
Revenue (TTM)
$25.17M
Div. yield
–
Gene and Cell Therapy Healthcare
3 wins

Head to Head

8 decided of 12

Beam Therapeutics leads on 4 of the 12 questions below (Beam Therapeutics 4, CRISPR Therapeutics AG 3, Taysha Gene Therapies 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionTSHABEAMCRSPLeader
Larger companyMarket capitalisation $1.61B $2.88B $5.00B CRSP
Cheaper on earningsLower P/E, profitable companies only -10.7x -33.7x -11.0x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — — — –
Faster revenue growthRevenue growth, trailing twelve months -32.3% +158.9% -34.3% BEAM
More profitableNet margin, trailing twelve months -2,728.0% -54.7% -1,812.1% BEAM
Better return on capitalReturn on invested capital — — -23.3% –
Less leveragedLower net debt / EBITDA 2.7x 3.0x 3.3x TSHA
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months -8.3% +8.6% -19.3% BEAM
Better 5-year returnAnnualised price return, 5 years -24.1%/yr -22.4%/yr -11.7%/yr CRSP
Less volatileAnnualised volatility, 1 year 70.8% 70.5% 57.4% CRSP
Higher overall scoreMean of the five percentile scores vs peers 48/100 69/100 48/100 BEAM

Percentile Scorecard

TSHABEAMCRSP

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisTSHABEAMCRSP
Valuation 46 #340 of 634 56 #277 of 634 52 #305 of 634
Growth 16 #508 of 607 78 #137 of 607 28 #440 of 607
Profitability 26 #410 of 557 65 #196 of 557 37 #350 of 557
Financial Health 76 #161 of 654 81 #127 of 654 70 #199 of 654
Shareholder Returns 78 #91 of 401 67 #135 of 401 52 #194 of 401
Overall 48 69 48
  • TSHA ranked among 671 companies in Pharmaceuticals and Biotechnology
  • BEAM ranked among 671 companies in Pharmaceuticals and Biotechnology
  • CRSP ranked among 671 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodTSHABEAMCRSPSPY
1 month -11.7%+7.5%-9.8% -2.0%
3 months -34.0%-7.1%-5.8% -2.2%
6 months -41.1%-8.9%-4.6% +4.2%
Year to date -25.6%-5.0%-4.7% +10.6%
1 year -8.3%+8.6%-19.3% +10.4%
3 years +64.9%+7.5%-2.0% +73.6%
3 years, per year +18.2%+2.4%-0.7% +20.2%
5 years -74.9%-71.8%-46.2% +61.6%
5 years, per year -24.1%-22.4%-11.7% +10.1%
10 years ——+226.3% +261.3%
10 years, per year ——+12.6% +13.7%

Risk

MeasureTSHABEAMCRSPSPY
Volatility, 1Y 70.8%70.5%57.4% 12.8%
Downside volatility, 1Y 68.1%64.1%54.4% 12.8%
Beta vs S&P 500, 1Y 1.832.111.87 1.00
Return / volatility, 1Y -0.120.12-0.34 0.81
Max drawdown, 5Y -96.4%-85.3%-66.8% -25.4%
From 52-week high -41.4%-30.6%-19.3% -3.2%
52-week high $6.98$37.92$61.97 $779.14
52-week low $3.51$20.60$44.34 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleTSHABEAMCRSP
P/E now vs peer median -10.1xmedian 18.4x -32.2xmedian 18.4x -10.6xmedian 18.4x
P/S now vs peer median 242.6xmedian 9.0x 17.4xmedian 9.0x 192.6xmedian 9.0x
EV/EBITDA now vs peer median -6.1xmedian 16.0x -4.7xmedian 16.0x -6.2xmedian 16.0x
P/FCF now vs peer median -10.0xmedian 21.8x -7.3xmedian 21.8x -12.9xmedian 21.8x
P/B now vs peer median 3.4xmedian 2.1x 2.5xmedian 2.1x 2.9xmedian 2.1x
PEG now vs peer median -0.25median 0.37 -0.76median 0.37 5.48median 0.37

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsTSHABEAMCRSP
Revenue $5.49M $156.04M $25.17M
Operating income -$153.16M -$378.02M -$532.33M
Net income -$149.63M -$86.52M -$456.14M
Free cash flow -$132.57M -$372.77M -$376.72M
R&D $123.14M $408.66M $291.14M
EPS (diluted) $-0.41 $-0.82 $-4.72
Cash & equivalents $455.41M $219.83M $192.03M
Total debt $49.26M $100.26M $586.93M
Shares (diluted) 369.04M 104.33M 96.74M
Enterprise value $256.22M -$1.81B -$4.05B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricTSHABEAMCRSP
P/E -10.1x -32.2x -10.6x
P/FCF -10.0x -7.3x -12.9x
P/Operating cash flow -10.1x -7.6x -12.9x
P/S 242.6x 17.4x 192.6x
P/B 3.4x 2.5x 2.9x
P/Tangible book 3.4x 2.5x 2.9x
EV/EBITDA -6.1x -4.7x -6.2x
EV/EBIT -6.0x -4.4x -5.9x
EV/Revenue 168.5x 10.7x 125.7x
EV/FCF -7.0x -4.5x -8.4x
EV/Operating cash flow -7.0x -4.6x -8.4x
PEG (3Y EPS CAGR) -0.25 -0.76 5.48

Growth

14 metrics
MetricTSHABEAMCRSP
Revenue growth (1Y) -32.3% 158.9% -34.3%
Revenue CAGR (3Y) -9.1% 24.9% -47.1%
Gross profit growth (1Y) – – –
Gross profit CAGR (3Y) – – –
Operating income growth (1Y) -62.9% 15.2% 7.3%
Operating income CAGR (3Y) -8.7% 0.3% -7.9%
Net income growth (1Y) -61.4% 78.2% 6.6%
Net income CAGR (3Y) -6.5% 35.8% -8.9%
EPS growth (1Y) -30.3% 79.0% 11.8%
EPS CAGR (3Y) 40.5% 42.4% -1.9%
Operating cash flow growth (1Y) -61.0% -4.2% -23.8%
Operating cash flow CAGR (3Y) -35.6% -2.0% -10.5%
Free cash flow growth (1Y) -60.6% -4.8% -24.3%
Free cash flow CAGR (3Y) -29.4% 0.7% -8.8%

Profitability

14 metrics
MetricTSHABEAMCRSP
Gross margin – – –
EBITDA margin -2,770% -228.0% -2,038%
Operating margin -2,792% -242.3% -2,115%
Pretax margin -2,593% -54.4% -1,802%
Net margin -2,728% -54.7% -1,812%
FCF margin -2,417% -238.9% -1,497%
Operating cash flow margin -2,410% -230.3% -1,488%
Return on equity -47.5% -7.6% -26.9%
Return on assets -36.9% -5.9% -17.5%
Return on invested capital – – -23.3%
Return on capital employed -42.6% -27.9% -21.6%
Asset turnover 0.0x 0.1x 0.0x
Cash conversion (OCF / net income) 0.9x 4.2x 0.8x
Stock comp / revenue 331.3% 52.2% 276.8%

Financial Health

11 metrics
MetricTSHABEAMCRSP
Debt / assets 10.5% 7.2% 23.0%
Debt / equity 0.1x 0.1x 0.4x
Net debt / EBITDA 2.7x 3.0x 3.3x
Debt / FCF -0.4x -0.3x -1.6x
Liabilities / assets 17.7% 23.0% 35.5%
Equity / assets 82.3% 77.0% 64.5%
Interest coverage -3,647x – –
Current ratio 17.8x 14.6x 16.2x
Quick ratio 17.5x 14.3x 16.1x
Cash ratio 17.5x 14.3x 16.1x
Altman Z-score 7.26 3.36 2.29

Shareholder Returns

7 metrics
MetricTSHABEAMCRSP
Dividend yield – – –
Net buyback yield -0.2% -0.5% -2.8%
Shareholder yield -0.2% -0.5% -2.8%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusTSHABEAMCRSP
EPS, next fiscal year $-0.47FY2026 $-4.22FY2026 $-4.10FY2026
Revenue, next fiscal year $1.96MFY2026 $49.46MFY2026 $38.73MFY2026
Revenue growth, next FY -80.0%FY2026 -64.6%FY2026 +1,003.4%FY2026
Revenue growth, the year after +1,298.6% +23.6% +266.1%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersTSHABEAMCRSP
Held by institutions 81.2% 100.0% 78.9%
Institutions holding 209 277 520
Change in shares held, QoQ +12.7% +1.0% -1.0%
Institutions buying 140 154 238
Institutions selling 42 75 139
Buyers to sellers 3.33 2.05 1.71

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

TSHABEAMCRSP
TSHA 1.00 0.45 0.44
BEAM 0.45 1.00 0.76
CRSP 0.44 0.76 1.00

Add a Peer

Largest companies in the same industry

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Frequently Asked Questions

Which is bigger, TSHA, BEAM and CRSP?

CRISPR Therapeutics AG (CRSP) is the largest by market capitalisation: Taysha Gene Therapies (TSHA) $1.61B, Beam Therapeutics (BEAM) $2.88B, CRISPR Therapeutics AG (CRSP) $5.00B.

Which company is growing faster?

Beam Therapeutics (BEAM) grew revenue fastest over the trailing twelve months: Taysha Gene Therapies (TSHA) -32.3%, Beam Therapeutics (BEAM) +158.9%, CRISPR Therapeutics AG (CRSP) -34.3%.

Which company is more profitable?

Beam Therapeutics (BEAM) has the highest net margin (Taysha Gene Therapies (TSHA) -2,728.0%, Beam Therapeutics (BEAM) -54.7%, CRISPR Therapeutics AG (CRSP) -1,812.1%).

Which stock has performed better?

Over the past year Beam Therapeutics (BEAM) returned the most: Taysha Gene Therapies (TSHA) -8.3%, Beam Therapeutics (BEAM) +8.6%, CRISPR Therapeutics AG (CRSP) -19.3%. Over five years, CRISPR Therapeutics AG (CRSP) compounded fastest (Taysha Gene Therapies (TSHA) -24.1%/yr, Beam Therapeutics (BEAM) -22.4%/yr, CRISPR Therapeutics AG (CRSP) -11.7%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, CRISPR Therapeutics AG (CRSP) has been the steadiest (Taysha Gene Therapies (TSHA) 70.8%, Beam Therapeutics (BEAM) 70.5%, CRISPR Therapeutics AG (CRSP) 57.4%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, TSHA, BEAM and CRSP?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Beam Therapeutics (BEAM) leads on 4. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.