SLBT vs KRYS vs VCEL Stock Comparison

SL Science Holding, Krystal Biotech and Vericel Prices as of Oct 29, 2026 Peers: Industry group
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KRYS Krystal Biotech, Inc.
$324.55 -3.1% 1M +75.4% 1Y
Market cap
$9.75B
P/E
40.4x
Revenue (TTM)
$440.53M
Div. yield
–
Gene and Cell Therapy Healthcare
8 wins
VCEL Vericel Corp
$42.91 +5.7% 1M +23.0% 1Y
Market cap
$2.05B
P/E
84.7x
Revenue (TTM)
$306.30M
Div. yield
–
Gene and Cell Therapy Healthcare
1 win

Head to Head

9 decided of 12

Krystal Biotech leads on 8 of the 12 questions below (Krystal Biotech 8, Vericel 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionSLBTKRYSVCELLeader
Larger companyMarket capitalisation $2.82B $9.75B $2.05B KRYS
Cheaper on earningsLower P/E, profitable companies only — 40.4x 84.7x KRYS
Cheaper on forward earningsLower price / next fiscal year consensus EPS — 46.8x 84.1x KRYS
Faster revenue growthRevenue growth, trailing twelve months — +22.6% +23.0% VCEL
More profitableNet margin, trailing twelve months — 54.8% 7.9% KRYS
Better return on capitalReturn on invested capital — — — –
Less leveragedLower net debt / EBITDA — — — –
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months -88.7% +75.4% +23.0% KRYS
Better 5-year returnAnnualised price return, 5 years — +45.4%/yr -1.4%/yr KRYS
Less volatileAnnualised volatility, 1 year 175.5% 38.0% 41.0% KRYS
Higher overall scoreMean of the five percentile scores vs peers — 85/100 81/100 KRYS

Percentile Scorecard

SLBTKRYSVCEL

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisSLBTKRYSVCEL
Valuation 11 #556 of 624 79 #131 of 624 82 #115 of 624
Growth – 93 #41 of 601 94 #36 of 601
Profitability – 96 #21 of 541 88 #64 of 541
Financial Health 58 #271 of 647 84 #103 of 647 69 #203 of 647
Shareholder Returns – 70 #108 of 359 73 #99 of 359
Overall – 85 81
  • SLBT ranked among 671 companies in Pharmaceuticals and Biotechnology
  • KRYS ranked among 671 companies in Pharmaceuticals and Biotechnology
  • VCEL ranked among 671 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodSLBTKRYSVCELSPY
1 month -36.1%-3.1%+5.7% +0.7%
3 months -56.5%-11.5%-9.9% +3.7%
6 months -87.4%+23.8%+23.6% +7.1%
Year to date -88.9%+31.6%+19.2% +12.8%
1 year -88.7%+75.4%+23.0% +11.9%
3 years —+178.9%+24.8% +85.2%
3 years, per year —+40.8%+7.7% +22.8%
5 years —+547.9%-6.8% +67.6%
5 years, per year —+45.4%-1.4% +10.9%
10 years ——+1,726.0% +262.0%
10 years, per year ——+33.7% +13.7%

Risk

MeasureSLBTKRYSVCELSPY
Volatility, 1Y 175.5%38.0%41.0% 12.7%
Downside volatility, 1Y 170.0%37.4%40.0% 12.6%
Beta vs S&P 500, 1Y 0.240.690.71 1.00
Return / volatility, 1Y -0.511.990.56 0.94
Max drawdown, 5Y -91.0%-44.5%-64.7% -25.4%
From 52-week high -90.9%-14.2%-11.2% -1.2%
52-week high $12.81$378.15$48.31 $779.14
52-week low $1.15$185.05$29.34 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleSLBTKRYSVCEL
P/E now vs peer median —median 17.8x 39.7xmedian 17.8x 90.5xmedian 17.8x
P/S now vs peer median —median 9.1x 21.8xmedian 9.1x 7.2xmedian 9.1x
EV/EBITDA now vs peer median —median 15.0x 43.0xmedian 15.0x 64.8xmedian 15.0x
P/FCF now vs peer median -1,359xmedian 21.7x 37.3xmedian 21.7x 35.6xmedian 21.7x
P/B now vs peer median 365.9xmedian 2.2x 7.1xmedian 2.2x 5.9xmedian 2.2x
PEG now vs peer median —median 0.35 0.77median 0.35 1.67median 0.35

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsSLBTKRYSVCEL
Revenue – $440.53M $306.30M
Gross profit – $416.91M $228.38M
Operating income – $197.75M $18.24M
Net income – $241.47M $24.22M
Free cash flow – $257.78M $61.66M
R&D – $59.23M $29.17M
EPS (diluted) – $7.88 $0.46
Cash & equivalents $8.31M $427.74M $125.40M
Shares (diluted) – 30.66M 52.31M
Enterprise value $2.80B $6.53B $1.47B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricSLBTKRYSVCEL
P/E – 39.7x 90.5x
P/FCF -1,359x 37.3x 35.6x
P/Operating cash flow – 35.3x 31.5x
P/S – 21.8x 7.2x
P/B 365.9x 7.1x 5.9x
P/Tangible book 365.9x 7.1x 6.0x
EV/EBITDA – 43.0x 64.8x
EV/EBIT – 44.3x 111.5x
EV/Revenue – 19.9x 6.6x
EV/FCF – 34.0x 33.0x
EV/Operating cash flow – 32.2x 29.2x
PEG (3Y EPS CAGR) – 0.77 1.67

Growth

14 metrics
MetricSLBTKRYSVCEL
Revenue growth (1Y) – 22.6% 23.0%
Revenue CAGR (3Y) – – 19.8%
Gross profit growth (1Y) – 24.3% 24.8%
Gross profit CAGR (3Y) – – 23.9%
Operating income growth (1Y) – 41.8% 1,428%
Operating income CAGR (3Y) – 48.8% 47.8%
Net income growth (1Y) – 64.6% 240.8%
Net income CAGR (3Y) – 54.9% 56.6%
EPS growth (1Y) – 59.7% 228.1%
EPS CAGR (3Y) – 51.8% 54.3%
Operating cash flow growth (1Y) – 39.4% 47.5%
Operating cash flow CAGR (3Y) – 67.0% 33.7%
Free cash flow growth (1Y) – 39.0% 842.9%
Free cash flow CAGR (3Y) – 58.6% 43.2%

Profitability

14 metrics
MetricSLBTKRYSVCEL
Gross margin – 94.6% 74.6%
EBITDA margin – 46.2% 10.2%
Operating margin – 44.9% 6.0%
Pretax margin – 51.4% 8.2%
Net margin – 54.8% 7.9%
FCF margin – 58.5% 20.1%
Operating cash flow margin – 61.8% 22.7%
Return on equity – 18.3% 6.9%
Return on assets – 16.7% 5.1%
Return on invested capital – – –
Return on capital employed – 15.0% 4.1%
Asset turnover – 0.3x 0.6x
Cash conversion (OCF / net income) – 1.1x 2.9x
Stock comp / revenue – 12.4% 12.2%

Financial Health

11 metrics
MetricSLBTKRYSVCEL
Debt / assets – – –
Debt / equity – – –
Net debt / EBITDA – – –
Debt / FCF – – –
Liabilities / assets 21.8% 9.4% 26.4%
Equity / assets 78.2% 90.6% 73.6%
Interest coverage – – 28.5x
Current ratio 4.4x 8.3x 5.0x
Quick ratio 4.3x 7.7x 4.5x
Cash ratio 4.3x 6.6x 3.1x
Altman Z-score – 42.32 10.09

Shareholder Returns

7 metrics
MetricSLBTKRYSVCEL
Dividend yield – – –
Net buyback yield – -0.4% -0.3%
Shareholder yield 0.0% -0.4% -0.3%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusSLBTKRYSVCEL
Forward P/E – 46.8xFY2026 84.1xFY2026
EPS, next fiscal year – $6.94FY2026 $0.51FY2026
EPS growth, next FY – +1.5%FY2026 +59.4%FY2026
EPS growth, the year after – +25.5% +74.5%
Revenue, next fiscal year – $514.54MFY2026 $324.56MFY2026
Revenue growth, next FY – +32.2%FY2026 +17.5%FY2026
Revenue growth, the year after – +33.4% +16.1%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersSLBTKRYSVCEL
Held by institutions – 99.8% 100.0%
Institutions holding – 422 318
Change in shares held, QoQ – +4.6% +0.4%
Institutions buying – 271 188
Institutions selling – 107 98
Buyers to sellers – 2.53 1.92

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

SLBTKRYSVCEL
SLBT 1.00 -0.07 0.02
KRYS -0.07 1.00 0.24
VCEL 0.02 0.24 1.00

Add a Peer

Largest companies in the same industry

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Frequently Asked Questions

Which is bigger, SLBT, KRYS and VCEL?

Krystal Biotech (KRYS) is the largest by market capitalisation: SL Science Holding (SLBT) $2.82B, Krystal Biotech (KRYS) $9.75B, Vericel (VCEL) $2.05B.

Which stock is cheaper, SLBT, KRYS and VCEL?

Krystal Biotech (KRYS) trades on the lowest price-to-earnings ratio (Krystal Biotech (KRYS) 40.4x, Vericel (VCEL) 84.7x). On next year's consensus earnings, Krystal Biotech (KRYS) is cheapest (Krystal Biotech (KRYS) 46.8x, Vericel (VCEL) 84.1x). A lower multiple can reflect slower expected growth, so read it next to the growth figures.

Which company is growing faster?

Vericel (VCEL) grew revenue fastest over the trailing twelve months: Krystal Biotech (KRYS) +22.6%, Vericel (VCEL) +23.0%.

Which company is more profitable?

Krystal Biotech (KRYS) has the highest net margin (Krystal Biotech (KRYS) 54.8%, Vericel (VCEL) 7.9%).

Which stock has performed better?

Over the past year Krystal Biotech (KRYS) returned the most: SL Science Holding (SLBT) -88.7%, Krystal Biotech (KRYS) +75.4%, Vericel (VCEL) +23.0%. Over five years, Krystal Biotech (KRYS) compounded fastest (Krystal Biotech (KRYS) +45.4%/yr, Vericel (VCEL) -1.4%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Krystal Biotech (KRYS) has been the steadiest (SL Science Holding (SLBT) 175.5%, Krystal Biotech (KRYS) 38.0%, Vericel (VCEL) 41.0%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, SLBT, KRYS and VCEL?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Krystal Biotech (KRYS) leads on 8. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.