PGEN vs CRSP vs NTLA Stock Comparison

Precigen, CRISPR Therapeutics AG and Intellia Therapeutics Prices as of Nov 2, 2026 Peers: Industry group
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PGEN Precigen, Inc.
$5.14 -39.8% 1M +24.2% 1Y
Market cap
$1.84B
P/E
–
Revenue (TTM)
$85.72M
Div. yield
–
Gene and Cell Therapy Healthcare
6 wins
CRSP CRISPR Therapeutics AG
$49.99 -9.8% 1M -21.9% 1Y
Market cap
$4.83B
P/E
–
Revenue (TTM)
$13.39M
Div. yield
–
Gene and Cell Therapy Healthcare
2 wins

Head to Head

8 decided of 12

Precigen leads on 6 of the 12 questions below (Precigen 6, CRISPR Therapeutics AG 2). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionPGENCRSPNTLALeader
Larger companyMarket capitalisation $1.84B $4.83B $1.63B CRSP
Cheaper on earningsLower P/E, profitable companies only -5.4x -10.7x -3.9x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS 30.2x — — –
Faster revenue growthRevenue growth, trailing twelve months +1,875.0% -64.8% +12.6% PGEN
More profitableNet margin, trailing twelve months -392.8% -3,368.7% -672.2% PGEN
Better return on capitalReturn on invested capital — -22.6% — –
Less leveragedLower net debt / EBITDA -1.6x 3.4x — PGEN
Higher dividend yieldTrailing dividend yield — — — –
Better 1-year returnPrice return, last 12 months +24.2% -21.9% -7.6% PGEN
Better 5-year returnAnnualised price return, 5 years -1.3%/yr -12.4%/yr -38.8%/yr PGEN
Less volatileAnnualised volatility, 1 year 84.1% 57.5% 80.0% CRSP
Higher overall scoreMean of the five percentile scores vs peers 54/100 44/100 49/100 PGEN

Percentile Scorecard

PGENCRSPNTLA

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisPGENCRSPNTLA
Valuation 56 #275 of 623 49 #317 of 623 34 #412 of 623
Growth 48 #311 of 601 32 #410 of 601 64 #220 of 601
Profitability 58 #232 of 553 32 #377 of 553 38 #341 of 553
Financial Health 26 #485 of 654 71 #190 of 654 71 #189 of 654
Shareholder Returns 81 #69 of 367 37 #230 of 367 39 #224 of 367
Overall 54 44 49
  • PGEN ranked among 671 companies in Pharmaceuticals and Biotechnology
  • CRSP ranked among 671 companies in Pharmaceuticals and Biotechnology
  • NTLA ranked among 671 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodPGENCRSPNTLASPY
1 month -39.8%-9.8%-4.9% -2.3%
3 months -22.2%+0.8%+8.3% -0.7%
6 months +24.2%-6.7%-15.9% +4.8%
Year to date +23.0%-4.7%+29.7% +10.3%
1 year +24.2%-21.9%-7.6% +10.3%
3 years +324.8%-2.0%-59.5% +73.0%
3 years, per year +62.0%-0.7%-26.0% +20.1%
5 years -6.5%-48.4%-91.4% +61.9%
5 years, per year -1.3%-12.4%-38.8% +10.1%
10 years -79.7%+225.6%-10.2% +258.6%
10 years, per year -14.8%+12.5%-1.1% +13.6%

Risk

MeasurePGENCRSPNTLASPY
Volatility, 1Y 84.1%57.5%80.0% 12.8%
Downside volatility, 1Y 81.1%54.4%81.8% 12.8%
Beta vs S&P 500, 1Y 1.441.882.46 1.00
Return / volatility, 1Y 0.29-0.38-0.10 0.80
Max drawdown, 5Y -87.8%-67.7%-95.5% -25.4%
From 52-week high -40.0%-19.3%-34.6% -3.5%
52-week high $8.56$61.97$17.84 $779.14
52-week low $3.10$44.34$8.04 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultiplePGENCRSPNTLA
P/E now vs peer median -5.4xmedian 17.4x -10.7xmedian 17.4x -3.9xmedian 17.4x
P/S now vs peer median 21.5xmedian 8.9x 360.8xmedian 8.9x 27.4xmedian 8.9x
EV/EBITDA now vs peer median -55.3xmedian 17.0x -5.9xmedian 17.0x -2.9xmedian 17.0x
P/FCF now vs peer median -16.0xmedian 21.4x -13.0xmedian 21.4x -4.7xmedian 21.4x
P/B now vs peer median 42.2xmedian 2.1x 2.8xmedian 2.1x 2.2xmedian 2.1x
PEG now vs peer median 0.04median 0.35 -2.78median 0.35 -0.24median 0.35

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsPGENCRSPNTLA
Revenue $85.72M $13.39M $59.51M
Gross profit $77.72M – –
Operating income -$39.50M -$534.34M -$423.48M
Net income -$157.71M -$451.14M -$399.98M
Free cash flow -$115.22M -$371.33M -$348.69M
R&D $32.29M $278.15M $346.73M
EPS (diluted) $-0.81 $-4.67 $-3.00
Cash & equivalents $16.33M $291.34M $106.13M
Total debt $93.88M $586.20M –
Shares (diluted) 413.69M 96.51M 133.48M
Enterprise value $1.53B -$3.87B -$142.06M

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricPGENCRSPNTLA
P/E -5.4x -10.7x -3.9x
P/FCF -16.0x -13.0x -4.7x
P/Operating cash flow -16.1x -13.1x -4.7x
P/S 21.5x 360.8x 27.4x
P/B 42.2x 2.8x 2.2x
P/Tangible book 44.8x 2.8x 2.2x
EV/EBITDA -55.3x -5.9x -2.9x
EV/EBIT -48.0x -5.7x -2.8x
EV/Revenue 22.1x 228.0x 20.1x
EV/FCF -16.5x -8.2x -3.4x
EV/Operating cash flow -16.6x -8.3x -3.4x
PEG (3Y EPS CAGR) 0.04 -2.78 -0.24

Growth

14 metrics
MetricPGENCRSPNTLA
Revenue growth (1Y) 1,875% -64.8% 12.6%
Revenue CAGR (3Y) 57.1% -57.1% 3.9%
Gross profit growth (1Y) 259,173% – –
Gross profit CAGR (3Y) 69.2% – –
Operating income growth (1Y) 62.1% 3.3% 17.3%
Operating income CAGR (3Y) 18.9% -4.1% 2.7%
Net income growth (1Y) -26.7% 3.6% 16.7%
Net income CAGR (3Y) -108.9% -2.7% 4.1%
EPS growth (1Y) -93.8% 13.0% 35.3%
EPS CAGR (3Y) -123.2% 3.9% 16.5%
Operating cash flow growth (1Y) -72.3% -13.8% 17.2%
Operating cash flow CAGR (3Y) -15.9% -2.5% 2.0%
Free cash flow growth (1Y) -65.1% -14.1% 17.3%
Free cash flow CAGR (3Y) -15.3% -0.9% 3.2%

Profitability

14 metrics
MetricPGENCRSPNTLA
Gross margin 90.7% – –
EBITDA margin -40.0% -3,850% -696.4%
Operating margin -46.1% -3,990% -711.7%
Pretax margin -184.0% -3,346% -671.0%
Net margin -392.8% -3,369% -672.2%
FCF margin -134.4% -2,773% -586.0%
Operating cash flow margin -133.2% -2,760% -582.5%
Return on equity -494.3% -25.3% -59.2%
Return on assets -102.1% -16.8% -49.4%
Return on invested capital – -22.6% –
Return on capital employed -31.6% -20.9% -58.1%
Asset turnover 0.6x 0.0x 0.1x
Cash conversion (OCF / net income) 0.7x 0.8x 0.9x
Stock comp / revenue 15.3% 510.2% 114.1%

Financial Health

11 metrics
MetricPGENCRSPNTLA
Debt / assets 55.1% 22.1% –
Debt / equity 2.2x 0.3x –
Net debt / EBITDA -1.6x 3.4x –
Debt / FCF -0.8x -1.6x –
Liabilities / assets 74.4% 34.1% 15.1%
Equity / assets 25.6% 65.9% 84.9%
Interest coverage -4.1x – –
Current ratio 4.6x 17.8x 6.6x
Quick ratio 3.8x 17.8x 5.6x
Cash ratio 1.3x 17.8x 5.5x
Altman Z-score -9.96 2.42 2.07

Shareholder Returns

7 metrics
MetricPGENCRSPNTLA
Dividend yield – – –
Net buyback yield -0.1% -8.8% -8.1%
Shareholder yield -0.1% -8.8% -8.1%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusPGENCRSPNTLA
Forward P/E 30.2xFY2026 – –
EPS, next fiscal year $0.17FY2026 $-4.10FY2026 $-3.38FY2026
EPS growth, the year after +288.2% – –
Revenue, next fiscal year $249.17MFY2026 $38.73MFY2026 $48.94MFY2026
Revenue growth, next FY +2,474.1%FY2026 +1,003.4%FY2026 -27.7%FY2026
Revenue growth, the year after +82.3% +266.1% +158.6%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersPGENCRSPNTLA
Held by institutions 39.2% 78.9% 100.0%
Institutions holding 211 520 329
Change in shares held, QoQ +4.9% -1.0% +30.5%
Institutions buying 123 238 195
Institutions selling 46 139 78
Buyers to sellers 2.67 1.71 2.50

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

PGENCRSPNTLA
PGEN 1.00 0.33 0.26
CRSP 0.33 1.00 0.70
NTLA 0.26 0.70 1.00

Add a Peer

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Frequently Asked Questions

Which is bigger, PGEN, CRSP and NTLA?

CRISPR Therapeutics AG (CRSP) is the largest by market capitalisation: Precigen (PGEN) $1.84B, CRISPR Therapeutics AG (CRSP) $4.83B, Intellia Therapeutics (NTLA) $1.63B.

Which company is growing faster?

Precigen (PGEN) grew revenue fastest over the trailing twelve months: Precigen (PGEN) +1,875.0%, CRISPR Therapeutics AG (CRSP) -64.8%, Intellia Therapeutics (NTLA) +12.6%.

Which company is more profitable?

Precigen (PGEN) has the highest net margin (Precigen (PGEN) -392.8%, CRISPR Therapeutics AG (CRSP) -3,368.7%, Intellia Therapeutics (NTLA) -672.2%).

Which stock has performed better?

Over the past year Precigen (PGEN) returned the most: Precigen (PGEN) +24.2%, CRISPR Therapeutics AG (CRSP) -21.9%, Intellia Therapeutics (NTLA) -7.6%. Over five years, Precigen (PGEN) compounded fastest (Precigen (PGEN) -1.3%/yr, CRISPR Therapeutics AG (CRSP) -12.4%/yr, Intellia Therapeutics (NTLA) -38.8%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, CRISPR Therapeutics AG (CRSP) has been the steadiest (Precigen (PGEN) 84.1%, CRISPR Therapeutics AG (CRSP) 57.5%, Intellia Therapeutics (NTLA) 80.0%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, PGEN, CRSP and NTLA?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Precigen (PGEN) leads on 6. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.