PGEN vs IOVA Stock Comparison

Precigen and Iovance Biotherapeutics Prices as of Oct 27, 2026 Peers: Industry group
PGEN Precigen, Inc.
$6.15 -20.6% 1M +43.0% 1Y
Market cap
$2.20B
P/E
–
Revenue (TTM)
$85.72M
Div. yield
–
Gene and Cell Therapy Healthcare
3 wins

Head to Head

7 decided of 12

Iovance Biotherapeutics leads on 4 of the 12 questions below (Iovance Biotherapeutics 4, Precigen 3). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionPGENIOVALeader
Larger companyMarket capitalisation $2.20B $6.60B IOVA
Cheaper on earningsLower P/E, profitable companies only -6.5x -22.7x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS 36.2x — –
Faster revenue growthRevenue growth, trailing twelve months +1,875.0% +34.5% PGEN
More profitableNet margin, trailing twelve months -392.8% -89.1% IOVA
Better return on capitalReturn on invested capital — — –
Less leveragedLower net debt / EBITDA -1.6x — –
Higher dividend yieldTrailing dividend yield — — –
Better 1-year returnPrice return, last 12 months +43.0% +531.2% IOVA
Better 5-year returnAnnualised price return, 5 years +4.4%/yr -10.4%/yr PGEN
Less volatileAnnualised volatility, 1 year 77.9% 99.2% PGEN
Higher overall scoreMean of the five percentile scores vs peers 55/100 64/100 IOVA

Percentile Scorecard

PGENIOVA

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisPGENIOVA
Valuation 59 #258 of 625 67 #209 of 625
Growth 49 #310 of 602 81 #114 of 602
Profitability 59 #227 of 551 62 #210 of 551
Financial Health 27 #482 of 656 64 #238 of 656
Shareholder Returns 83 #63 of 365 44 #205 of 365
Overall 55 64
  • PGEN ranked among 672 companies in Pharmaceuticals and Biotechnology
  • IOVA ranked among 672 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodPGENIOVASPY
1 month -20.6%+32.5% -0.2%
3 months +11.2%+210.2% +3.9%
6 months +53.0%+331.4% +8.2%
Year to date +47.1%+434.1% +12.9%
1 year +43.0%+531.2% +12.3%
3 years +508.9%+316.6% +87.4%
3 years, per year +82.7%+61.0% +23.3%
5 years +24.0%-42.3% +67.9%
5 years, per year +4.4%-10.4% +10.9%
10 years -76.2%+143.0% +261.1%
10 years, per year -13.4%+9.3% +13.7%

Risk

MeasurePGENIOVASPY
Volatility, 1Y 77.9%99.2% 12.7%
Downside volatility, 1Y 69.4%71.2% 12.7%
Beta vs S&P 500, 1Y 1.431.28 1.00
Return / volatility, 1Y 0.555.36 0.97
Max drawdown, 5Y -87.8%-93.4% -25.4%
From 52-week high -28.2%-1.9% -1.2%
52-week high $8.56$14.86 $779.14
52-week low $3.10$1.81 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultiplePGENIOVA
P/E now vs peer median -6.5xmedian 17.2x -22.7xmedian 17.2x
P/S now vs peer median 25.7xmedian 9.0x 20.3xmedian 9.0x
EV/EBITDA now vs peer median -65.8xmedian 16.3x -23.9xmedian 16.3x
P/FCF now vs peer median -19.1xmedian 18.7x -22.3xmedian 18.7x
P/B now vs peer median 50.5xmedian 2.2x 9.0xmedian 2.2x
PEG now vs peer median 0.05median 0.33 -0.76median 0.33

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsPGENIOVA
Revenue $85.72M $324.97M
Gross profit $77.72M $157.29M
Operating income -$39.50M -$301.31M
Net income -$157.71M -$289.51M
Free cash flow -$115.22M -$296.40M
R&D $32.29M $267.72M
EPS (diluted) $-0.81 $-0.64
Cash & equivalents $16.33M $110.80M
Total debt $93.88M –
Shares (diluted) 413.69M 450.19M
Enterprise value $1.89B $5.40B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricPGENIOVA
P/E -6.5x -22.7x
P/FCF -19.1x -22.3x
P/Operating cash flow -19.3x -25.0x
P/S 25.7x 20.3x
P/B 50.5x 9.0x
P/Tangible book 53.7x 14.0x
EV/EBITDA -65.8x -23.9x
EV/EBIT -57.2x -20.9x
EV/Revenue 26.3x 19.4x
EV/FCF -19.6x -21.3x
EV/Operating cash flow -19.8x -23.9x
PEG (3Y EPS CAGR) 0.05 -0.76

Growth

14 metrics
MetricPGENIOVA
Revenue growth (1Y) 1,875% 34.5%
Revenue CAGR (3Y) 57.1% 1,009%
Gross profit growth (1Y) 259,173% 95.1%
Gross profit CAGR (3Y) 69.2% –
Operating income growth (1Y) 62.1% 26.6%
Operating income CAGR (3Y) 18.9% 11.1%
Net income growth (1Y) -26.7% 25.8%
Net income CAGR (3Y) -108.9% 11.6%
EPS growth (1Y) -93.8% 44.8%
EPS CAGR (3Y) -123.2% 29.9%
Operating cash flow growth (1Y) -72.3% 12.9%
Operating cash flow CAGR (3Y) -15.9% 7.6%
Free cash flow growth (1Y) -65.1% 8.4%
Free cash flow CAGR (3Y) -15.3% 5.8%

Profitability

14 metrics
MetricPGENIOVA
Gross margin 90.7% 48.4%
EBITDA margin -40.0% -81.4%
Operating margin -46.1% -92.7%
Pretax margin -184.0% -90.4%
Net margin -392.8% -89.1%
FCF margin -134.4% -91.2%
Operating cash flow margin -133.2% -81.3%
Return on equity -494.3% -39.7%
Return on assets -102.1% -31.4%
Return on invested capital – –
Return on capital employed -31.6% -37.0%
Asset turnover 0.6x 0.4x
Cash conversion (OCF / net income) 0.7x 0.9x
Stock comp / revenue 15.3% 14.4%

Financial Health

11 metrics
MetricPGENIOVA
Debt / assets 55.1% –
Debt / equity 2.2x –
Net debt / EBITDA -1.6x –
Debt / FCF -0.8x –
Liabilities / assets 74.4% 19.6%
Equity / assets 25.6% 80.4%
Interest coverage -4.1x –
Current ratio 4.6x 4.3x
Quick ratio 3.8x 3.7x
Cash ratio 1.3x 2.8x
Altman Z-score -8.25 17.38

Shareholder Returns

7 metrics
MetricPGENIOVA
Dividend yield – –
Net buyback yield -0.1% -4.5%
Shareholder yield -0.1% -4.5%
Payout ratio (earnings) – –
Payout ratio (FCF) – –
Dividend growth (1Y) – –
Dividend CAGR (3Y) – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusPGENIOVA
Forward P/E 36.2xFY2026 –
EPS, next fiscal year $0.17FY2026 $-0.47FY2026
EPS growth, the year after +288.2% –
Revenue, next fiscal year $249.17MFY2026 $434.71MFY2026
Revenue growth, next FY +2,474.1%FY2026 +65.0%FY2026
Revenue growth, the year after +82.3% +33.0%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersPGENIOVA
Held by institutions 39.2% 63.3%
Institutions holding 210 292
Change in shares held, QoQ +4.9% +6.5%
Institutions buying 123 174
Institutions selling 46 66
Buyers to sellers 2.67 2.64

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

PGENIOVA
PGEN 1.00 0.27
IOVA 0.27 1.00

Add a Peer

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Frequently Asked Questions

Which is bigger, PGEN and IOVA?

Iovance Biotherapeutics (IOVA) is the largest by market capitalisation: Precigen (PGEN) $2.20B, Iovance Biotherapeutics (IOVA) $6.60B.

Which company is growing faster?

Precigen (PGEN) grew revenue fastest over the trailing twelve months: Precigen (PGEN) +1,875.0%, Iovance Biotherapeutics (IOVA) +34.5%.

Which company is more profitable?

Iovance Biotherapeutics (IOVA) has the highest net margin (Precigen (PGEN) -392.8%, Iovance Biotherapeutics (IOVA) -89.1%).

Which stock has performed better?

Over the past year Iovance Biotherapeutics (IOVA) returned the most: Precigen (PGEN) +43.0%, Iovance Biotherapeutics (IOVA) +531.2%. Over five years, Precigen (PGEN) compounded fastest (Precigen (PGEN) +4.4%/yr, Iovance Biotherapeutics (IOVA) -10.4%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Precigen (PGEN) has been the steadiest (Precigen (PGEN) 77.9%, Iovance Biotherapeutics (IOVA) 99.2%). Volatility measures how widely the price swings, not the risk of the business.

Do PGEN and IOVA move together?

Their daily returns over the past year have a correlation of 0.27, a weak relationship. Holding both diversifies more than two closely linked stocks would.

Which is the better stock, PGEN and IOVA?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Iovance Biotherapeutics (IOVA) leads on 4. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.