ISRG vs MDT vs PEN Stock Comparison

Intuitive Surgical, Medtronic and Penumbra Prices as of Nov 5, 2026 Peers: Industry group
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ISRG Intuitive Surgical Inc
$468.52 +15.8% 1M -14.6% 1Y
Market cap
$162.39B
P/E
55.3x
Revenue (TTM)
$11.58B
Div. yield
–
Medical Devices Healthcare
5 wins
MDT Medtronic plc
$104.83 +20.4% 1M +16.0% 1Y
Market cap
$134.19B
P/E
25.6x
Revenue (TTM)
$37.54B
Div. yield
2.73%
Medical Devices Healthcare
2 wins
PEN Penumbra Inc
$321.18 +1.3% 1M +42.4% 1Y
Market cap
$12.66B
P/E
80.6x
Revenue (TTM)
$1.56B
Div. yield
–
Medical Devices Healthcare
2 wins

Head to Head

9 decided of 12

Intuitive Surgical leads on 5 of the 12 questions below (Intuitive Surgical 5, Medtronic 2, Penumbra 2). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionISRGMDTPENLeader
Larger companyMarket capitalisation $162.39B $134.19B $12.66B ISRG
Cheaper on earningsLower P/E, profitable companies only 55.3x 25.6x 80.6x MDT
Cheaper on forward earningsLower price / next fiscal year consensus EPS 40.7x 18.8x 73.0x MDT
Faster revenue growthRevenue growth, trailing twelve months +20.5% +9.8% +17.0% ISRG
More profitableNet margin, trailing twelve months 25.5% 13.9% 10.1% ISRG
Better return on capitalReturn on invested capital — 6.9% — –
Less leveragedLower net debt / EBITDA — 2.0x — –
Higher dividend yieldTrailing dividend yield — 2.73% — –
Better 1-year returnPrice return, last 12 months -14.6% +16.0% +42.4% PEN
Better 5-year returnAnnualised price return, 5 years +5.1%/yr -3.1%/yr +2.4%/yr ISRG
Less volatileAnnualised volatility, 1 year 35.9% 25.6% 25.2% PEN
Higher overall scoreMean of the five percentile scores vs peers 79/100 64/100 74/100 ISRG

Percentile Scorecard

ISRGMDTPEN

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisISRGMDTPEN
Valuation 47 #123 of 229 80 #47 of 229 52 #111 of 229
Growth 81 #44 of 221 50 #112 of 221 87 #29 of 221
Profitability 97 #7 of 210 88 #26 of 210 85 #32 of 210
Financial Health 81 #47 of 240 50 #120 of 240 88 #30 of 240
Shareholder Returns 93 #12 of 147 54 #68 of 147 56 #65 of 147
Overall 79 64 74
  • ISRG ranked among 247 companies in Medical Devices and Diagnostics
  • MDT ranked among 247 companies in Medical Devices and Diagnostics
  • PEN ranked among 247 companies in Medical Devices and Diagnostics

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodISRGMDTPENSPY
1 month +15.8%+20.4%+1.3% -5.9%
3 months +25.4%+22.0%-1.1% -4.6%
6 months +3.3%+34.5%-1.1% +0.2%
Year to date -17.3%+9.1%+3.3% +7.5%
1 year -14.6%+16.0%+42.4% +8.2%
3 years +69.0%+42.8%+61.6% +68.3%
3 years, per year +19.1%+12.6%+17.4% +19.0%
5 years +28.4%-14.8%+12.6% +56.5%
5 years, per year +5.1%-3.1%+2.4% +9.4%
10 years +528.0%+27.6%+434.9% +251.5%
10 years, per year +20.2%+2.5%+18.3% +13.4%

Risk

MeasureISRGMDTPENSPY
Volatility, 1Y 35.9%25.6%25.2% 13.6%
Downside volatility, 1Y 38.0%22.0%15.1% 14.2%
Beta vs S&P 500, 1Y 0.930.140.11 1.00
Return / volatility, 1Y -0.410.621.68 0.60
Max drawdown, 5Y -49.9%-43.6%-59.6% -25.4%
From 52-week high -21.0%-0.5%-10.6% -5.9%
52-week high $592.85$105.35$359.40 $779.14
52-week low $332.02$73.75$225.54 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleISRGMDTPEN
P/E now vs peer median 55.3xmedian 26.9x 25.6xmedian 26.9x 80.6xmedian 26.9x
P/S now vs peer median 14.0xmedian 2.9x 3.6xmedian 2.9x 8.1xmedian 2.9x
EV/EBITDA now vs peer median 38.7xmedian 17.5x 15.8xmedian 17.5x 57.2xmedian 17.5x
P/FCF now vs peer median 45.1xmedian 26.4x 21.9xmedian 26.4x 63.2xmedian 26.4x
P/B now vs peer median 10.1xmedian 2.3x 2.6xmedian 2.3x 8.0xmedian 2.3x
PEG now vs peer median 2.15median 0.88 1.77median 0.88 1.43median 0.88

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsISRGMDTPEN
Revenue $11.58B $37.54B $1.56B
Gross profit $7.78B $24.41B $1.06B
Operating income $3.28B $6.79B $189.25M
Net income $2.97B $5.27B $157.02M
Free cash flow $3.60B $6.13B $200.29M
R&D $1.49B $2.92B $94.93M
EPS (diluted) $8.41 $4.07 $3.96
Cash & equivalents $2.98B $1.69B $254.28M
Total debt – $28.15B –
Shares (diluted) 351.60M 1.29B 39.62M
Enterprise value $142.81B $100.06B $10.17B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricISRGMDTPEN
P/E 55.3x 25.6x 80.6x
P/FCF 45.1x 21.9x 63.2x
P/Operating cash flow 39.7x 16.7x 48.5x
P/S 14.0x 3.6x 8.1x
P/B 10.1x 2.6x 8.0x
P/Tangible book 10.9x 3.3x 8.0x
EV/EBITDA 38.7x 15.8x 57.2x
EV/EBIT 48.2x 22.6x 63.3x
EV/Revenue 13.7x 4.1x 7.7x
EV/FCF 44.0x 25.0x 59.8x
EV/Operating cash flow 38.7x 19.1x 45.9x
PEG (3Y EPS CAGR) 2.15 1.77 1.43

Growth

14 metrics
MetricISRGMDTPEN
Revenue growth (1Y) 20.5% 9.8% 17.0%
Revenue CAGR (3Y) 19.1% 6.0% 16.2%
Gross profit growth (1Y) 21.9% 9.3% 19.1%
Gross profit CAGR (3Y) 19.5% 5.6% 18.7%
Operating income growth (1Y) 16.6% 10.9% 9.5%
Operating income CAGR (3Y) 24.8% 6.4% 63.4%
Net income growth (1Y) 7.5% 12.4% -4.3%
Net income CAGR (3Y) 24.4% 13.0% 56.9%
EPS growth (1Y) 10.8% 12.4% -5.0%
EPS CAGR (3Y) 25.7% 14.5% 56.4%
Operating cash flow growth (1Y) 38.1% 12.4% 28.4%
Operating cash flow CAGR (3Y) 26.4% 11.3% 61.1%
Free cash flow growth (1Y) 58.4% 15.6% 31.2%
Free cash flow CAGR (3Y) 42.0% 11.3% 61.8%

Profitability

14 metrics
MetricISRGMDTPEN
Gross margin 67.2% 65.0% 68.0%
EBITDA margin 35.3% 25.9% 13.4%
Operating margin 28.4% 18.1% 12.1%
Pretax margin 31.3% 17.6% 13.3%
Net margin 25.5% 13.9% 10.1%
FCF margin 31.1% 16.3% 12.8%
Operating cash flow margin 35.3% 21.4% 16.7%
Return on equity 17.3% 10.4% 10.1%
Return on assets 14.8% 5.7% 7.8%
Return on invested capital – 6.9% –
Return on capital employed 18.7% 8.3% 10.7%
Asset turnover 0.6x 0.4x 0.8x
Cash conversion (OCF / net income) 1.4x 1.5x 1.7x
Stock comp / revenue 7.2% 1.3% 3.7%

Financial Health

11 metrics
MetricISRGMDTPEN
Debt / assets – 30.2% –
Debt / equity – 0.6x –
Net debt / EBITDA – 2.0x –
Debt / FCF – 4.6x –
Liabilities / assets 16.7% 45.5% 21.8%
Equity / assets 83.3% 54.5% 78.2%
Interest coverage – 9.4x –
Current ratio 3.3x 2.1x 5.9x
Quick ratio 2.3x 1.3x 3.7x
Cash ratio 1.6x 0.7x 2.9x
Altman Z-score 32.00 3.20 19.20

Shareholder Returns

7 metrics
MetricISRGMDTPEN
Dividend yield – 2.7% –
Net buyback yield 2.6% 0.1% -0.1%
Shareholder yield 2.6% 2.9% -0.1%
Payout ratio (earnings) – 69.3% –
Payout ratio (FCF) – 59.5% –
Dividend growth (1Y) – 1.4% –
Dividend CAGR (3Y) – 0.2% –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusISRGMDTPEN
Forward P/E 40.7xFY2026 18.8xFY2026 73.0xFY2026
EPS, next fiscal year $11.51FY2026 $5.57FY2026 $4.40FY2026
EPS growth, next FY +28.9%FY2026 +0.7%FY2026 +14.6%FY2026
EPS growth, the year after +4.5% +7.2% +43.9%
Revenue, next fiscal year $11.61BFY2026 $39.92BFY2026 $1.64BFY2026
Revenue growth, next FY +15.4%FY2026 +9.8%FY2026 +17.0%FY2026
Revenue growth, the year after +11.2% -4.7% +7.4%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersISRGMDTPEN
Held by institutions 86.2% 85.1% 86.6%
Institutions holding 2,240 2,127 451
Change in shares held, QoQ +4.6% -0.2% +0.9%
Institutions buying 1,072 1,014 195
Institutions selling 879 915 182
Buyers to sellers 1.22 1.11 1.07

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

ISRGMDTPEN
ISRG 1.00 0.47 0.19
MDT 0.47 1.00 0.29
PEN 0.19 0.29 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, ISRG, MDT and PEN?

Intuitive Surgical (ISRG) is the largest by market capitalisation: Intuitive Surgical (ISRG) $162.39B, Medtronic (MDT) $134.19B, Penumbra (PEN) $12.66B.

Which stock is cheaper, ISRG, MDT and PEN?

Medtronic (MDT) trades on the lowest price-to-earnings ratio (Intuitive Surgical (ISRG) 55.3x, Medtronic (MDT) 25.6x, Penumbra (PEN) 80.6x). On next year's consensus earnings, Medtronic (MDT) is cheapest (Intuitive Surgical (ISRG) 40.7x, Medtronic (MDT) 18.8x, Penumbra (PEN) 73.0x). A lower multiple can reflect slower expected growth, so read it next to the growth figures.

Which company is growing faster?

Intuitive Surgical (ISRG) grew revenue fastest over the trailing twelve months: Intuitive Surgical (ISRG) +20.5%, Medtronic (MDT) +9.8%, Penumbra (PEN) +17.0%.

Which company is more profitable?

Intuitive Surgical (ISRG) has the highest net margin (Intuitive Surgical (ISRG) 25.5%, Medtronic (MDT) 13.9%, Penumbra (PEN) 10.1%).

Which stock has performed better?

Over the past year Penumbra (PEN) returned the most: Intuitive Surgical (ISRG) -14.6%, Medtronic (MDT) +16.0%, Penumbra (PEN) +42.4%. Over five years, Intuitive Surgical (ISRG) compounded fastest (Intuitive Surgical (ISRG) +5.1%/yr, Medtronic (MDT) -3.1%/yr, Penumbra (PEN) +2.4%/yr). Returns are price only, before dividends.

Which pays a higher dividend?

Only one of these companies pays a dividend: Medtronic (MDT) 2.73%. Intuitive Surgical (ISRG) and Penumbra (PEN) pays no regular dividend.

Which stock is riskier?

By one-year price volatility, Penumbra (PEN) has been the steadiest (Intuitive Surgical (ISRG) 35.9%, Medtronic (MDT) 25.6%, Penumbra (PEN) 25.2%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, ISRG, MDT and PEN?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Intuitive Surgical (ISRG) leads on 5. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.