IOVA vs SRPT vs SLBT Stock Comparison

Iovance Biotherapeutics, Sarepta Therapeutics and SL Science Holding Prices as of Nov 3, 2026 Peers: Industry group
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Head to Head

7 decided of 12

Iovance Biotherapeutics leads on 4 of the 12 questions below (Iovance Biotherapeutics 4, Sarepta Therapeutics 3). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionIOVASRPTSLBTLeader
Larger companyMarket capitalisation $3.95B $2.00B $2.59B IOVA
Cheaper on earningsLower P/E, profitable companies only -13.6x -17.1x — –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — 6.4x — –
Faster revenue growthRevenue growth, trailing twelve months +34.5% -20.4% — IOVA
More profitableNet margin, trailing twelve months -89.1% -5.9% — SRPT
Better return on capitalReturn on invested capital — -6.1% — –
Less leveragedLower net debt / EBITDA — -0.6x — –
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months +352.8% -24.2% -88.3% IOVA
Better 5-year returnAnnualised price return, 5 years -18.5%/yr -26.6%/yr — IOVA
Less volatileAnnualised volatility, 1 year 109.4% 81.1% 175.7% SRPT
Higher overall scoreMean of the five percentile scores vs peers 63/100 67/100 — SRPT

Percentile Scorecard

IOVASRPTSLBT

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisIOVASRPTSLBT
Valuation 65 #224 of 634 96 #24 of 634 12 #561 of 634
Growth 82 #111 of 607 64 #222 of 607 –
Profitability 63 #205 of 557 80 #114 of 557 –
Financial Health 62 #250 of 654 34 #434 of 654 58 #278 of 654
Shareholder Returns 41 #238 of 401 61 #156 of 401 –
Overall 63 67 –
  • IOVA ranked among 671 companies in Pharmaceuticals and Biotechnology
  • SRPT ranked among 671 companies in Pharmaceuticals and Biotechnology
  • SLBT ranked among 671 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodIOVASRPTSLBTSPY
1 month -37.9%+5.9%-22.3% -2.0%
3 months +102.5%+13.1%-60.4% -2.2%
6 months +121.9%-14.9%-85.6% +4.2%
Year to date +223.4%-13.8%-88.4% +10.6%
1 year +352.8%-24.2%-88.3% +10.4%
3 years +109.7%-76.2%— +73.6%
3 years, per year +28.0%-38.1%— +20.2%
5 years -64.0%-78.7%— +61.6%
5 years, per year -18.5%-26.6%— +10.1%
10 years +50.9%-50.1%— +261.3%
10 years, per year +4.2%-6.7%— +13.7%

Risk

MeasureIOVASRPTSLBTSPY
Volatility, 1Y 109.4%81.1%175.7% 12.8%
Downside volatility, 1Y 94.7%85.6%169.4% 12.8%
Beta vs S&P 500, 1Y 1.542.080.17 1.00
Return / volatility, 1Y 3.22-0.30-0.50 0.81
Max drawdown, 5Y -93.4%-92.7%-91.0% -25.4%
From 52-week high -40.6%-24.2%-90.5% -3.2%
52-week high $14.86$24.45$12.81 $779.14
52-week low $1.81$14.86$1.15 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleIOVASRPTSLBT
P/E now vs peer median -13.7xmedian 18.4x -16.7xmedian 18.4x —median 18.4x
P/S now vs peer median 12.3xmedian 9.0x 1.0xmedian 9.0x —median 9.0x
EV/EBITDA now vs peer median -14.0xmedian 16.0x -20.5xmedian 16.0x —median 16.0x
P/FCF now vs peer median -13.5xmedian 21.8x 23.9xmedian 21.8x -1,417xmedian 21.8x
P/B now vs peer median 5.4xmedian 2.1x 1.3xmedian 2.1x 381.5xmedian 2.1x
PEG now vs peer median -0.46median 0.37 -0.32median 0.37 —median 0.37

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsIOVASRPTSLBT
Revenue $324.97M $1.97B –
Gross profit $157.29M $1.17B –
Operating income -$301.31M -$143.25M –
Net income -$289.51M -$136.73M –
Free cash flow -$296.40M $81.85M –
R&D $267.72M $789.44M –
EPS (diluted) $-0.64 $-1.11 –
Cash & equivalents $110.80M $571.15M $8.31M
Total debt – $847.62M –
Shares (diluted) 450.19M 105.43M –
Enterprise value $2.74B -$1.23B $2.58B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricIOVASRPTSLBT
P/E -13.7x -16.7x –
P/FCF -13.5x 23.9x -1,417x
P/Operating cash flow -15.1x 17.6x –
P/S 12.3x 1.0x –
P/B 5.4x 1.3x 381.5x
P/Tangible book 8.5x 1.3x 381.5x
EV/EBITDA -14.0x -20.5x –
EV/EBIT -12.3x -14.1x –
EV/Revenue 11.4x 1.0x –
EV/FCF -12.5x 24.6x –
EV/Operating cash flow -14.0x 18.2x –
PEG (3Y EPS CAGR) -0.46 -0.32 –

Growth

14 metrics
MetricIOVASRPTSLBT
Revenue growth (1Y) 34.5% -20.4% –
Revenue CAGR (3Y) 1,009% 25.3% –
Gross profit growth (1Y) 95.1% -40.7% –
Gross profit CAGR (3Y) – 10.6% –
Operating income growth (1Y) 26.6% -15,270% –
Operating income CAGR (3Y) 11.1% 34.5% –
Net income growth (1Y) 25.8% -135.9% –
Net income CAGR (3Y) 11.6% 46.8% –
EPS growth (1Y) 44.8% -215.7% –
EPS CAGR (3Y) 29.9% 52.3% –
Operating cash flow growth (1Y) 12.9% 136.9% –
Operating cash flow CAGR (3Y) 7.6% 30.6% –
Free cash flow growth (1Y) 8.4% 118.1% –
Free cash flow CAGR (3Y) 5.8% 29.1% –

Profitability

14 metrics
MetricIOVASRPTSLBT
Gross margin 48.4% 59.1% –
EBITDA margin -81.4% -5.0% –
Operating margin -92.7% -7.3% –
Pretax margin -90.4% -6.6% –
Net margin -89.1% -5.9% –
FCF margin -91.2% 4.1% –
Operating cash flow margin -81.3% 5.6% –
Return on equity -39.7% -9.0% –
Return on assets -31.4% -4.3% –
Return on invested capital – -6.1% –
Return on capital employed -37.0% -5.3% –
Asset turnover 0.4x 0.6x –
Cash conversion (OCF / net income) 0.9x -0.8x –
Stock comp / revenue 14.4% 6.3% –

Financial Health

11 metrics
MetricIOVASRPTSLBT
Debt / assets – 26.6% –
Debt / equity – 0.6x –
Net debt / EBITDA – -0.6x –
Debt / FCF – 10.4x –
Liabilities / assets 19.6% 52.1% 21.8%
Equity / assets 80.4% 47.9% 78.2%
Interest coverage – – –
Current ratio 4.3x 4.4x 4.4x
Quick ratio 3.7x 2.4x 4.3x
Cash ratio 2.8x 1.6x 4.3x
Altman Z-score 8.67 -0.17 –

Shareholder Returns

7 metrics
MetricIOVASRPTSLBT
Dividend yield – – –
Net buyback yield -7.4% -1.1% –
Shareholder yield -7.4% -1.1% 0.0%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusIOVASRPTSLBT
Forward P/E – 6.4xFY2026 –
EPS, next fiscal year $-0.47FY2026 $2.88FY2026 –
EPS growth, the year after – -88.5% –
Revenue, next fiscal year $434.71MFY2026 $1.76BFY2026 –
Revenue growth, next FY +65.0%FY2026 -20.1%FY2026 –
Revenue growth, the year after +33.0% -21.5% –

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersIOVASRPTSLBT
Held by institutions 63.3% 100.0% –
Institutions holding 292 326 –
Change in shares held, QoQ +6.5% +4.5% –
Institutions buying 174 148 –
Institutions selling 66 117 –
Buyers to sellers 2.64 1.26 –

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

IOVASRPTSLBT
IOVA 1.00 0.28 0.01
SRPT 0.28 1.00 0.00
SLBT 0.01 0.00 1.00

Add a Peer

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Frequently Asked Questions

Which is bigger, IOVA, SRPT and SLBT?

Iovance Biotherapeutics (IOVA) is the largest by market capitalisation: Iovance Biotherapeutics (IOVA) $3.95B, Sarepta Therapeutics (SRPT) $2.00B, SL Science Holding (SLBT) $2.59B.

Which company is growing faster?

Iovance Biotherapeutics (IOVA) grew revenue fastest over the trailing twelve months: Iovance Biotherapeutics (IOVA) +34.5%, Sarepta Therapeutics (SRPT) -20.4%.

Which company is more profitable?

Sarepta Therapeutics (SRPT) has the highest net margin (Iovance Biotherapeutics (IOVA) -89.1%, Sarepta Therapeutics (SRPT) -5.9%).

Which stock has performed better?

Over the past year Iovance Biotherapeutics (IOVA) returned the most: Iovance Biotherapeutics (IOVA) +352.8%, Sarepta Therapeutics (SRPT) -24.2%, SL Science Holding (SLBT) -88.3%. Over five years, Iovance Biotherapeutics (IOVA) compounded fastest (Iovance Biotherapeutics (IOVA) -18.5%/yr, Sarepta Therapeutics (SRPT) -26.6%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Sarepta Therapeutics (SRPT) has been the steadiest (Iovance Biotherapeutics (IOVA) 109.4%, Sarepta Therapeutics (SRPT) 81.1%, SL Science Holding (SLBT) 175.7%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, IOVA, SRPT and SLBT?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Iovance Biotherapeutics (IOVA) leads on 4. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.