IOVA vs CRSP Stock Comparison

Iovance Biotherapeutics and CRISPR Therapeutics AG Prices as of Oct 23, 2026 Peers: Industry group
CRSP CRISPR Therapeutics AG
$49.39 -11.4% 1M -26.5% 1Y
Market cap
$4.73B
P/E
–
Revenue (TTM)
$13.39M
Div. yield
–
Gene and Cell Therapy Healthcare
1 win

Head to Head

7 decided of 12

Iovance Biotherapeutics leads on 6 of the 12 questions below (Iovance Biotherapeutics 6, CRISPR Therapeutics AG 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionIOVACRSPLeader
Larger companyMarket capitalisation $6.19B $4.73B IOVA
Cheaper on earningsLower P/E, profitable companies only -21.4x -10.5x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — — –
Faster revenue growthRevenue growth, trailing twelve months +34.5% -64.8% IOVA
More profitableNet margin, trailing twelve months -89.1% -3,368.7% IOVA
Better return on capitalReturn on invested capital — -22.6% –
Less leveragedLower net debt / EBITDA — 3.4x –
Higher dividend yieldTrailing dividend yield 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months +543.4% -26.5% IOVA
Better 5-year returnAnnualised price return, 5 years -11.3%/yr -12.4%/yr IOVA
Less volatileAnnualised volatility, 1 year 99.0% 57.0% CRSP
Higher overall scoreMean of the five percentile scores vs peers 63/100 44/100 IOVA

Percentile Scorecard

IOVACRSP

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisIOVACRSP
Valuation 66 #213 of 624 48 #324 of 624
Growth 81 #114 of 603 32 #413 of 603
Profitability 62 #212 of 555 32 #379 of 555
Financial Health 64 #238 of 657 71 #190 of 657
Shareholder Returns 44 #208 of 370 37 #232 of 370
Overall 63 44
  • IOVA ranked among 671 companies in Pharmaceuticals and Biotechnology
  • CRSP ranked among 671 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodIOVACRSPSPY
1 month +38.3%-11.4% -1.0%
3 months +182.4%+6.1% +2.9%
6 months +309.6%+1.2% +6.4%
Year to date +416.1%-5.8% +11.4%
1 year +543.4%-26.5% +13.1%
3 years +257.6%+19.0% +79.4%
3 years, per year +53.0%+6.0% +21.5%
5 years -45.0%-48.3% +67.7%
5 years, per year -11.3%-12.4% +10.9%
10 years +118.4%+257.4% +255.2%
10 years, per year +8.1%+13.6% +13.5%

Risk

MeasureIOVACRSPSPY
Volatility, 1Y 99.0%57.0% 12.7%
Downside volatility, 1Y 71.4%53.8% 12.7%
Beta vs S&P 500, 1Y 1.291.79 1.00
Return / volatility, 1Y 5.49-0.46 1.03
Max drawdown, 5Y -93.7%-67.7% -25.4%
From 52-week high -5.2%-26.9% -2.5%
52-week high $14.86$67.61 $779.14
52-week low $1.81$44.34 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleIOVACRSP
P/E now vs peer median -21.9xmedian 17.2x -10.6xmedian 17.2x
P/S now vs peer median 19.6xmedian 8.8x 356.5xmedian 8.8x
EV/EBITDA now vs peer median -23.0xmedian 16.0x -5.8xmedian 16.0x
P/FCF now vs peer median -21.5xmedian 17.8x -12.9xmedian 17.8x
P/B now vs peer median 8.7xmedian 2.1x 2.7xmedian 2.1x
PEG now vs peer median -0.73median 0.32 -2.74median 0.32

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsIOVACRSP
Revenue $324.97M $13.39M
Gross profit $157.29M –
Operating income -$301.31M -$534.34M
Net income -$289.51M -$451.14M
Free cash flow -$296.40M -$371.33M
R&D $267.72M $278.15M
EPS (diluted) $-0.64 $-4.67
Cash & equivalents $110.80M $291.34M
Total debt – $586.20M
Shares (diluted) 450.19M 96.51M
Enterprise value $4.98B -$3.97B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricIOVACRSP
P/E -21.9x -10.6x
P/FCF -21.5x -12.9x
P/Operating cash flow -24.2x -12.9x
P/S 19.6x 356.5x
P/B 8.7x 2.7x
P/Tangible book 13.5x 2.7x
EV/EBITDA -23.0x -5.8x
EV/EBIT -20.2x -5.6x
EV/Revenue 18.7x 223.7x
EV/FCF -20.5x -8.1x
EV/Operating cash flow -23.0x -8.1x
PEG (3Y EPS CAGR) -0.73 -2.74

Growth

14 metrics
MetricIOVACRSP
Revenue growth (1Y) 34.5% -64.8%
Revenue CAGR (3Y) 1,009% -57.1%
Gross profit growth (1Y) 95.1% –
Gross profit CAGR (3Y) – –
Operating income growth (1Y) 26.6% 3.3%
Operating income CAGR (3Y) 11.1% -4.1%
Net income growth (1Y) 25.8% 3.6%
Net income CAGR (3Y) 11.6% -2.7%
EPS growth (1Y) 44.8% 13.0%
EPS CAGR (3Y) 29.9% 3.9%
Operating cash flow growth (1Y) 12.9% -13.8%
Operating cash flow CAGR (3Y) 7.6% -2.5%
Free cash flow growth (1Y) 8.4% -14.1%
Free cash flow CAGR (3Y) 5.8% -0.9%

Profitability

14 metrics
MetricIOVACRSP
Gross margin 48.4% –
EBITDA margin -81.4% -3,850%
Operating margin -92.7% -3,990%
Pretax margin -90.4% -3,346%
Net margin -89.1% -3,369%
FCF margin -91.2% -2,773%
Operating cash flow margin -81.3% -2,760%
Return on equity -39.7% -25.3%
Return on assets -31.4% -16.8%
Return on invested capital – -22.6%
Return on capital employed -37.0% -20.9%
Asset turnover 0.4x 0.0x
Cash conversion (OCF / net income) 0.9x 0.8x
Stock comp / revenue 14.4% 510.2%

Financial Health

11 metrics
MetricIOVACRSP
Debt / assets – 22.1%
Debt / equity – 0.3x
Net debt / EBITDA – 3.4x
Debt / FCF – -1.6x
Liabilities / assets 19.6% 34.1%
Equity / assets 80.4% 65.9%
Interest coverage – –
Current ratio 4.3x 17.8x
Quick ratio 3.7x 17.8x
Cash ratio 2.8x 17.8x
Altman Z-score 16.64 2.38

Shareholder Returns

7 metrics
MetricIOVACRSP
Dividend yield – –
Net buyback yield -4.6% -8.9%
Shareholder yield -4.6% -8.9%
Payout ratio (earnings) – –
Payout ratio (FCF) – –
Dividend growth (1Y) – –
Dividend CAGR (3Y) – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusIOVACRSP
EPS, next fiscal year $-0.47FY2026 $-4.12FY2026
Revenue, next fiscal year $434.71MFY2026 $38.73MFY2026
Revenue growth, next FY +65.0%FY2026 +1,003.4%FY2026
Revenue growth, the year after +33.0% +259.5%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersIOVACRSP
Held by institutions 63.3% 78.9%
Institutions holding 292 518
Change in shares held, QoQ +6.5% -1.0%
Institutions buying 174 237
Institutions selling 66 139
Buyers to sellers 2.64 1.71

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

IOVACRSP
IOVA 1.00 0.36
CRSP 0.36 1.00

Add a Peer

Largest companies in the same industry

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Frequently Asked Questions

Which is bigger, IOVA and CRSP?

Iovance Biotherapeutics (IOVA) is the largest by market capitalisation: Iovance Biotherapeutics (IOVA) $6.19B, CRISPR Therapeutics AG (CRSP) $4.73B.

Which company is growing faster?

Iovance Biotherapeutics (IOVA) grew revenue fastest over the trailing twelve months: Iovance Biotherapeutics (IOVA) +34.5%, CRISPR Therapeutics AG (CRSP) -64.8%.

Which company is more profitable?

Iovance Biotherapeutics (IOVA) has the highest net margin (Iovance Biotherapeutics (IOVA) -89.1%, CRISPR Therapeutics AG (CRSP) -3,368.7%).

Which stock has performed better?

Over the past year Iovance Biotherapeutics (IOVA) returned the most: Iovance Biotherapeutics (IOVA) +543.4%, CRISPR Therapeutics AG (CRSP) -26.5%. Over five years, Iovance Biotherapeutics (IOVA) compounded fastest (Iovance Biotherapeutics (IOVA) -11.3%/yr, CRISPR Therapeutics AG (CRSP) -12.4%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, CRISPR Therapeutics AG (CRSP) has been the steadiest (Iovance Biotherapeutics (IOVA) 99.0%, CRISPR Therapeutics AG (CRSP) 57.0%). Volatility measures how widely the price swings, not the risk of the business.

Do IOVA and CRSP move together?

Their daily returns over the past year have a correlation of 0.36, a weak relationship. Holding both diversifies more than two closely linked stocks would.

Which is the better stock, IOVA and CRSP?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Iovance Biotherapeutics (IOVA) leads on 6. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.