IOVA vs PGEN vs VCEL Stock Comparison

Iovance Biotherapeutics, Precigen and Vericel Prices as of Nov 2, 2026 Peers: Industry group
1 more company in this comparison (KRYS) Create a free account to keep reading and compare up to 10 companies.
PGEN Precigen, Inc.
$5.14 -39.8% 1M +24.2% 1Y
Market cap
$1.78B
P/E
–
Revenue (TTM)
$85.72M
Div. yield
–
Gene and Cell Therapy Healthcare
3 wins
VCEL Vericel Corp
$40.51 +0.9% 1M +15.5% 1Y
Market cap
$2.27B
P/E
93.8x
Revenue (TTM)
$306.30M
Div. yield
–
Gene and Cell Therapy Healthcare
3 wins

Head to Head

8 decided of 12

Precigen leads on 3 of the 12 questions below (Precigen 3, Vericel 3, Iovance Biotherapeutics 2). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionIOVAPGENVCELLeader
Larger companyMarket capitalisation $3.83B $1.78B $2.27B IOVA
Cheaper on earningsLower P/E, profitable companies only -13.2x -5.3x 93.8x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — 30.9x 80.6x PGEN
Faster revenue growthRevenue growth, trailing twelve months +34.5% +1,875.0% +23.0% PGEN
More profitableNet margin, trailing twelve months -89.1% -392.8% 7.9% VCEL
Better return on capitalReturn on invested capital — — — –
Less leveragedLower net debt / EBITDA — -1.6x — –
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months +307.1% +24.2% +15.5% IOVA
Better 5-year returnAnnualised price return, 5 years -20.3%/yr -1.3%/yr -4.1%/yr PGEN
Less volatileAnnualised volatility, 1 year 109.3% 84.1% 41.3% VCEL
Higher overall scoreMean of the five percentile scores vs peers 61/100 54/100 81/100 VCEL

Percentile Scorecard

IOVAPGENVCEL

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisIOVAPGENVCEL
Valuation 63 #233 of 623 56 #275 of 623 82 #115 of 623
Growth 81 #113 of 601 48 #311 of 601 94 #36 of 601
Profitability 62 #212 of 553 58 #232 of 553 88 #65 of 553
Financial Health 62 #252 of 654 26 #485 of 654 68 #208 of 654
Shareholder Returns 39 #225 of 367 81 #69 of 367 72 #103 of 367
Overall 61 54 81
  • IOVA ranked among 671 companies in Pharmaceuticals and Biotechnology
  • PGEN ranked among 671 companies in Pharmaceuticals and Biotechnology
  • VCEL ranked among 671 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodIOVAPGENVCELSPY
1 month -43.6%-39.8%+0.9% -2.3%
3 months +85.6%-22.2%-12.0% -0.7%
6 months +108.3%+24.2%+11.0% +4.8%
Year to date +193.8%+23.0%+12.5% +10.3%
1 year +307.1%+24.2%+15.5% +10.3%
3 years +90.5%+324.8%+9.9% +73.0%
3 years, per year +24.0%+62.0%+3.2% +20.1%
5 years -67.7%-6.5%-19.0% +61.9%
5 years, per year -20.3%-1.3%-4.1% +10.1%
10 years +35.9%-79.7%+1,741.4% +258.6%
10 years, per year +3.1%-14.8%+33.8% +13.6%

Risk

MeasureIOVAPGENVCELSPY
Volatility, 1Y 109.3%84.1%41.3% 12.8%
Downside volatility, 1Y 94.7%81.1%41.1% 12.8%
Beta vs S&P 500, 1Y 1.531.440.76 1.00
Return / volatility, 1Y 2.810.290.38 0.80
Max drawdown, 5Y -93.4%-87.8%-64.7% -25.4%
From 52-week high -46.0%-40.0%-16.1% -3.5%
52-week high $14.86$8.56$48.31 $779.14
52-week low $1.81$3.10$29.34 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleIOVAPGENVCEL
P/E now vs peer median -12.5xmedian 17.4x -5.4xmedian 17.4x 85.4xmedian 17.4x
P/S now vs peer median 11.2xmedian 8.9x 21.5xmedian 8.9x 6.8xmedian 8.9x
EV/EBITDA now vs peer median -12.6xmedian 17.0x -55.3xmedian 17.0x 60.9xmedian 17.0x
P/FCF now vs peer median -12.3xmedian 21.4x -16.0xmedian 21.4x 33.6xmedian 21.4x
P/B now vs peer median 4.9xmedian 2.1x 42.2xmedian 2.1x 5.6xmedian 2.1x
PEG now vs peer median -0.42median 0.35 0.04median 0.35 1.57median 0.35

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsIOVAPGENVCEL
Revenue $324.97M $85.72M $306.30M
Gross profit $157.29M $77.72M $228.38M
Operating income -$301.31M -$39.50M $18.24M
Net income -$289.51M -$157.71M $24.22M
Free cash flow -$296.40M -$115.22M $61.66M
R&D $267.72M $32.29M $29.17M
EPS (diluted) $-0.64 $-0.81 $0.46
Cash & equivalents $110.80M $16.33M $125.40M
Total debt – $93.88M –
Shares (diluted) 450.19M 413.69M 52.31M
Enterprise value $2.62B $1.46B $1.69B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricIOVAPGENVCEL
P/E -12.5x -5.4x 85.4x
P/FCF -12.3x -16.0x 33.6x
P/Operating cash flow -13.8x -16.1x 29.8x
P/S 11.2x 21.5x 6.8x
P/B 4.9x 42.2x 5.6x
P/Tangible book 7.7x 44.8x 5.7x
EV/EBITDA -12.6x -55.3x 60.9x
EV/EBIT -11.1x -48.0x 104.8x
EV/Revenue 10.3x 22.1x 6.2x
EV/FCF -11.3x -16.5x 31.0x
EV/Operating cash flow -12.6x -16.6x 27.4x
PEG (3Y EPS CAGR) -0.42 0.04 1.57

Growth

14 metrics
MetricIOVAPGENVCEL
Revenue growth (1Y) 34.5% 1,875% 23.0%
Revenue CAGR (3Y) 1,009% 57.1% 19.8%
Gross profit growth (1Y) 95.1% 259,173% 24.8%
Gross profit CAGR (3Y) – 69.2% 23.9%
Operating income growth (1Y) 26.6% 62.1% 1,428%
Operating income CAGR (3Y) 11.1% 18.9% 47.8%
Net income growth (1Y) 25.8% -26.7% 240.8%
Net income CAGR (3Y) 11.6% -108.9% 56.6%
EPS growth (1Y) 44.8% -93.8% 228.1%
EPS CAGR (3Y) 29.9% -123.2% 54.3%
Operating cash flow growth (1Y) 12.9% -72.3% 47.5%
Operating cash flow CAGR (3Y) 7.6% -15.9% 33.7%
Free cash flow growth (1Y) 8.4% -65.1% 842.9%
Free cash flow CAGR (3Y) 5.8% -15.3% 43.2%

Profitability

14 metrics
MetricIOVAPGENVCEL
Gross margin 48.4% 90.7% 74.6%
EBITDA margin -81.4% -40.0% 10.2%
Operating margin -92.7% -46.1% 6.0%
Pretax margin -90.4% -184.0% 8.2%
Net margin -89.1% -392.8% 7.9%
FCF margin -91.2% -134.4% 20.1%
Operating cash flow margin -81.3% -133.2% 22.7%
Return on equity -39.7% -494.3% 6.9%
Return on assets -31.4% -102.1% 5.1%
Return on invested capital – – –
Return on capital employed -37.0% -31.6% 4.1%
Asset turnover 0.4x 0.6x 0.6x
Cash conversion (OCF / net income) 0.9x 0.7x 2.9x
Stock comp / revenue 14.4% 15.3% 12.2%

Financial Health

11 metrics
MetricIOVAPGENVCEL
Debt / assets – 55.1% –
Debt / equity – 2.2x –
Net debt / EBITDA – -1.6x –
Debt / FCF – -0.8x –
Liabilities / assets 19.6% 74.4% 26.4%
Equity / assets 80.4% 25.6% 73.6%
Interest coverage – -4.1x 28.5x
Current ratio 4.3x 4.6x 5.0x
Quick ratio 3.7x 3.8x 4.5x
Cash ratio 2.8x 1.3x 3.1x
Altman Z-score 7.44 -9.96 9.54

Shareholder Returns

7 metrics
MetricIOVAPGENVCEL
Dividend yield – – –
Net buyback yield -8.1% -0.1% -0.3%
Shareholder yield -8.1% -0.1% -0.3%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusIOVAPGENVCEL
Forward P/E – 30.9xFY2026 80.6xFY2026
EPS, next fiscal year $-0.47FY2026 $0.17FY2026 $0.51FY2026
EPS growth, next FY – – +59.4%FY2026
EPS growth, the year after – +288.2% +74.5%
Revenue, next fiscal year $434.71MFY2026 $249.17MFY2026 $324.56MFY2026
Revenue growth, next FY +65.0%FY2026 +2,474.1%FY2026 +17.5%FY2026
Revenue growth, the year after +33.0% +82.3% +16.1%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersIOVAPGENVCEL
Held by institutions 63.3% 39.2% 100.0%
Institutions holding 292 211 319
Change in shares held, QoQ +6.5% +4.9% +0.4%
Institutions buying 174 123 188
Institutions selling 66 46 99
Buyers to sellers 2.64 2.67 1.90

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

IOVAPGENVCEL
IOVA 1.00 0.20 0.15
PGEN 0.20 1.00 0.14
VCEL 0.15 0.14 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, IOVA, PGEN and VCEL?

Iovance Biotherapeutics (IOVA) is the largest by market capitalisation: Iovance Biotherapeutics (IOVA) $3.83B, Precigen (PGEN) $1.78B, Vericel (VCEL) $2.27B.

Which company is growing faster?

Precigen (PGEN) grew revenue fastest over the trailing twelve months: Iovance Biotherapeutics (IOVA) +34.5%, Precigen (PGEN) +1,875.0%, Vericel (VCEL) +23.0%.

Which company is more profitable?

Vericel (VCEL) has the highest net margin (Iovance Biotherapeutics (IOVA) -89.1%, Precigen (PGEN) -392.8%, Vericel (VCEL) 7.9%).

Which stock has performed better?

Over the past year Iovance Biotherapeutics (IOVA) returned the most: Iovance Biotherapeutics (IOVA) +307.1%, Precigen (PGEN) +24.2%, Vericel (VCEL) +15.5%. Over five years, Precigen (PGEN) compounded fastest (Iovance Biotherapeutics (IOVA) -20.3%/yr, Precigen (PGEN) -1.3%/yr, Vericel (VCEL) -4.1%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Vericel (VCEL) has been the steadiest (Iovance Biotherapeutics (IOVA) 109.3%, Precigen (PGEN) 84.1%, Vericel (VCEL) 41.3%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, IOVA, PGEN and VCEL?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Precigen (PGEN) leads on 3. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.