IMTX vs SLBT vs KRYS Stock Comparison

Immatics, SL Science Holding and Krystal Biotech Prices as of Nov 3, 2026 Peers: Industry group
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IMTX Immatics N.V.
$7.07 -6.9% 1M -27.0% 1Y
Market cap
$845.43M
P/E
–
Revenue (TTM)
$48.61M
Div. yield
–
Gene and Cell Therapy Healthcare
KRYS Krystal Biotech, Inc.
$305.03 -5.4% 1M +54.2% 1Y
Market cap
$9.17B
P/E
40.7x
Revenue (TTM)
$470.07M
Div. yield
–
Gene and Cell Therapy Healthcare
7 wins

Head to Head

7 decided of 12

Krystal Biotech leads on 7 of the 12 questions below (Krystal Biotech 7). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionIMTXSLBTKRYSLeader
Larger companyMarket capitalisation $845.43M $2.59B $9.17B KRYS
Cheaper on earningsLower P/E, profitable companies only -3.5x — 40.7x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — — 44.0x –
Faster revenue growthRevenue growth, trailing twelve months -65.4% — +26.0% KRYS
More profitableNet margin, trailing twelve months -495.7% — 47.9% KRYS
Better return on capitalReturn on invested capital — — — –
Less leveragedLower net debt / EBITDA — — — –
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months -27.0% -88.3% +54.2% KRYS
Better 5-year returnAnnualised price return, 5 years -11.2%/yr — +42.8%/yr KRYS
Less volatileAnnualised volatility, 1 year 57.4% 175.7% 39.7% KRYS
Higher overall scoreMean of the five percentile scores vs peers 36/100 — 85/100 KRYS

Percentile Scorecard

IMTXSLBTKRYS

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisIMTXSLBTKRYS
Valuation 31 #437 of 634 12 #561 of 634 82 #117 of 634
Growth 4 #582 of 607 – 95 #32 of 607
Profitability 45 #306 of 557 – 98 #14 of 557
Financial Health 74 #170 of 654 58 #278 of 654 84 #109 of 654
Shareholder Returns 27 #294 of 401 – 68 #128 of 401
Overall 36 – 85
  • IMTX ranked among 671 companies in Pharmaceuticals and Biotechnology
  • SLBT ranked among 671 companies in Pharmaceuticals and Biotechnology
  • KRYS ranked among 671 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodIMTXSLBTKRYSSPY
1 month -6.9%-22.3%-5.4% -2.0%
3 months -24.6%-60.4%-6.1% -2.2%
6 months -35.4%-85.6%+7.2% +4.2%
Year to date -32.7%-88.4%+23.7% +10.6%
1 year -27.0%-88.3%+54.2% +10.4%
3 years -26.4%—+149.7% +73.6%
3 years, per year -9.7%—+35.7% +20.2%
5 years -44.9%—+492.9% +61.6%
5 years, per year -11.2%—+42.8% +10.1%

Risk

MeasureIMTXSLBTKRYSSPY
Volatility, 1Y 57.4%175.7%39.7% 12.8%
Downside volatility, 1Y 59.0%169.4%40.9% 12.8%
Beta vs S&P 500, 1Y 1.380.170.70 1.00
Return / volatility, 1Y -0.47-0.501.37 0.81
Max drawdown, 5Y -74.1%-91.0%-44.5% -25.4%
From 52-week high -40.4%-90.5%-19.3% -3.2%
52-week high $11.87$12.81$378.15 $779.14
52-week low $6.73$1.15$197.85 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleIMTXSLBTKRYS
P/E now vs peer median -3.6xmedian 18.4x —median 18.4x 40.1xmedian 18.4x
P/S now vs peer median 19.5xmedian 9.0x —median 9.0x 19.2xmedian 9.0x
EV/EBITDA now vs peer median -2.0xmedian 16.0x —median 16.0x 34.8xmedian 16.0x
P/FCF now vs peer median -3.9xmedian 21.8x -1,417xmedian 21.8x 29.1xmedian 21.8x
P/B now vs peer median 2.1xmedian 2.1x 381.5xmedian 2.1x 6.3xmedian 2.1x
PEG now vs peer median 0.15median 0.37 —median 0.37 0.37median 0.37

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsIMTXSLBTKRYS
Revenue $48.61M – $470.07M
Gross profit – – $443.16M
Operating income -$264.59M – $227.52M
Net income -$240.97M – $225.17M
Free cash flow -$244.28M – $310.08M
R&D $254.77M – $59.53M
EPS (diluted) $-1.97 – $7.30
Cash & equivalents $265.52M $8.31M $462.84M
Shares (diluted) 122.35M – 30.84M
Enterprise value -$1.18B $2.58B $5.77B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricIMTXSLBTKRYS
P/E -3.6x – 40.1x
P/FCF -3.9x -1,417x 29.1x
P/Operating cash flow -3.9x – 27.9x
P/S 19.5x – 19.2x
P/B 2.1x 381.5x 6.3x
P/Tangible book 2.1x 381.5x 6.3x
EV/EBITDA -2.0x – 34.8x
EV/EBIT -1.9x – 35.7x
EV/Revenue 10.3x – 17.3x
EV/FCF -2.0x – 26.2x
EV/Operating cash flow -2.1x – 25.1x
PEG (3Y EPS CAGR) 0.15 – 0.37

Growth

14 metrics
MetricIMTXSLBTKRYS
Revenue growth (1Y) -65.4% – 26.0%
Revenue CAGR (3Y) -47.1% – 280.2%
Gross profit growth (1Y) – – 26.0%
Gross profit CAGR (3Y) – – 276.1%
Operating income growth (1Y) -176.1% – 43.6%
Operating income CAGR (3Y) -58.8% – 52.4%
Net income growth (1Y) -187.4% – 13.2%
Net income CAGR (3Y) -37.5% – 112.2%
EPS growth (1Y) -180.7% – 9.5%
EPS CAGR (3Y) -23.8% – 108.6%
Operating cash flow growth (1Y) -33.6% – 83.8%
Operating cash flow CAGR (3Y) -39.1% – 72.3%
Free cash flow growth (1Y) -29.2% – 87.3%
Free cash flow CAGR (3Y) -30.7% – 66.4%

Profitability

14 metrics
MetricIMTXSLBTKRYS
Gross margin – – 94.3%
EBITDA margin -515.5% – 49.7%
Operating margin -544.3% – 48.4%
Pretax margin -496.3% – 55.1%
Net margin -495.7% – 47.9%
FCF margin -502.6% – 66.0%
Operating cash flow margin -493.8% – 68.9%
Return on equity -49.2% – 16.1%
Return on assets -40.9% – 14.6%
Return on invested capital – – –
Return on capital employed -50.5% – 16.2%
Asset turnover 0.1x – 0.3x
Cash conversion (OCF / net income) 1.0x – 1.4x
Stock comp / revenue 42.1% – 11.8%

Financial Health

11 metrics
MetricIMTXSLBTKRYS
Debt / assets – – –
Debt / equity – – –
Net debt / EBITDA – – –
Debt / FCF – – –
Liabilities / assets 17.7% 21.8% 9.5%
Equity / assets 82.3% 78.2% 90.5%
Interest coverage -3.2x – –
Current ratio 7.5x 4.4x 7.9x
Quick ratio 7.0x 4.3x 7.4x
Cash ratio 6.9x 4.3x 6.4x
Altman Z-score 2.60 – 37.73

Shareholder Returns

7 metrics
MetricIMTXSLBTKRYS
Dividend yield – – –
Net buyback yield -15.9% – -0.5%
Shareholder yield -15.9% 0.0% -0.5%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusIMTXSLBTKRYS
Forward P/E – – 44.0xFY2026
EPS, next fiscal year $-2.10FY2026 – $6.94FY2026
EPS growth, next FY – – +1.5%FY2026
EPS growth, the year after – – +25.5%
Revenue, next fiscal year $40.64MFY2026 – $514.54MFY2026
Revenue growth, next FY -28.4%FY2026 – +32.2%FY2026
Revenue growth, the year after -11.9% – +33.4%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersIMTXSLBTKRYS
Held by institutions 81.6% – 100.0%
Institutions holding 83 – 423
Change in shares held, QoQ -7.8% – +7.0%
Institutions buying 37 – 272
Institutions selling 33 – 107
Buyers to sellers 1.12 – 2.54

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

IMTXSLBTKRYS
IMTX 1.00 -0.03 0.24
SLBT -0.03 1.00 -0.08
KRYS 0.24 -0.08 1.00

Add a Peer

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Frequently Asked Questions

Which is bigger, IMTX, SLBT and KRYS?

Krystal Biotech (KRYS) is the largest by market capitalisation: Immatics (IMTX) $845.43M, SL Science Holding (SLBT) $2.59B, Krystal Biotech (KRYS) $9.17B.

Which company is growing faster?

Krystal Biotech (KRYS) grew revenue fastest over the trailing twelve months: Immatics (IMTX) -65.4%, Krystal Biotech (KRYS) +26.0%.

Which company is more profitable?

Krystal Biotech (KRYS) has the highest net margin (Immatics (IMTX) -495.7%, Krystal Biotech (KRYS) 47.9%).

Which stock has performed better?

Over the past year Krystal Biotech (KRYS) returned the most: Immatics (IMTX) -27.0%, SL Science Holding (SLBT) -88.3%, Krystal Biotech (KRYS) +54.2%. Over five years, Krystal Biotech (KRYS) compounded fastest (Immatics (IMTX) -11.2%/yr, Krystal Biotech (KRYS) +42.8%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Krystal Biotech (KRYS) has been the steadiest (Immatics (IMTX) 57.4%, SL Science Holding (SLBT) 175.7%, Krystal Biotech (KRYS) 39.7%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, IMTX, SLBT and KRYS?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Krystal Biotech (KRYS) leads on 7. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.