ILMN vs RVTY vs TWST Stock Comparison

Illumina, Revvity and Twist Bioscience Prices as of Oct 29, 2026 Peers: Industry group
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ILMN Illumina, Inc.
$290.06 +6.6% 1M +205.2% 1Y
Market cap
$35.91B
P/E
40.1x
Revenue (TTM)
$4.54B
Div. yield
–
Life Sciences Tools Healthcare
3 wins
RVTY Revvity, Inc.
$165.78 +8.6% 1M +74.0% 1Y
Market cap
$17.52B
P/E
73.7x
Revenue (TTM)
$2.91B
Div. yield
0.00%
Life Sciences Tools Healthcare
4 wins
TWST Twist Bioscience Corp
$173.45 -6.8% 1M +438.5% 1Y
Market cap
$9.63B
P/E
–
Revenue (TTM)
$431.80M
Div. yield
–
Life Sciences Tools Healthcare
4 wins

Head to Head

11 decided of 12

Revvity leads on 4 of the 12 questions below (Revvity 4, Twist Bioscience 4, Illumina 3). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionILMNRVTYTWSTLeader
Larger companyMarket capitalisation $35.91B $17.52B $9.63B ILMN
Cheaper on earningsLower P/E, profitable companies only 40.1x 73.7x -70.4x ILMN
Cheaper on forward earningsLower price / next fiscal year consensus EPS 58.1x 32.5x — RVTY
Faster revenue growthRevenue growth, trailing twelve months +5.8% +4.1% +19.2% TWST
More profitableNet margin, trailing twelve months — 8.2% -31.7% RVTY
Better return on capitalReturn on invested capital — 3.1% -31.1% RVTY
Less leveragedLower net debt / EBITDA — 2.8x 1.3x TWST
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months +205.2% +74.0% +438.5% TWST
Better 5-year returnAnnualised price return, 5 years -6.4%/yr -1.3%/yr +7.9%/yr TWST
Less volatileAnnualised volatility, 1 year 50.3% 39.8% 79.0% RVTY
Higher overall scoreMean of the five percentile scores vs peers 68/100 58/100 51/100 ILMN

Percentile Scorecard

ILMNRVTYTWST

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisILMNRVTYTWST
Valuation 41 #134 of 227 69 #72 of 227 30 #159 of 227
Growth 63 #81 of 218 28 #157 of 218 56 #96 of 218
Profitability 100 #1 of 202 81 #40 of 202 42 #118 of 202
Financial Health – 47 #124 of 233 73 #63 of 233
Shareholder Returns – 66 #45 of 130 51 #64 of 130
Overall 68 58 51
  • ILMN ranked among 247 companies in Medical Devices and Diagnostics
  • RVTY ranked among 247 companies in Medical Devices and Diagnostics
  • TWST ranked among 247 companies in Medical Devices and Diagnostics

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodILMNRVTYTWSTSPY
1 month +6.6%+8.6%-6.8% +0.7%
3 months +41.4%+46.0%+89.9% +3.7%
6 months +128.9%+91.4%+196.7% +7.1%
Year to date +121.1%+71.3%+446.8% +12.8%
1 year +205.2%+74.0%+438.5% +11.9%
3 years +176.4%+102.0%+1,050.2% +85.2%
3 years, per year +40.4%+26.4%+125.9% +22.8%
5 years -28.2%-6.3%+46.0% +67.6%
5 years, per year -6.4%-1.3%+7.9% +10.9%
10 years +115.1%+226.3%— +262.0%
10 years, per year +8.0%+12.6%— +13.7%

Risk

MeasureILMNRVTYTWSTSPY
Volatility, 1Y 50.3%39.8%79.0% 12.7%
Downside volatility, 1Y 39.0%36.0%69.8% 12.6%
Beta vs S&P 500, 1Y 0.831.232.71 1.00
Return / volatility, 1Y 4.081.865.55 0.94
Max drawdown, 5Y -82.9%-59.2%-91.5% -25.4%
From 52-week high -1.2%0.0%-15.4% -1.2%
52-week high $293.69$165.78$205.00 $779.14
52-week low $95.03$82.26$25.45 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleILMNRVTYTWST
P/E now vs peer median 48.9xmedian 28.7x 77.9xmedian 28.7x -79.1xmedian 28.7x
P/S now vs peer median 9.7xmedian 3.0x 6.4xmedian 3.0x 25.2xmedian 3.0x
EV/EBITDA now vs peer median —median 17.8x 26.7xmedian 17.8x -89.6xmedian 17.8x
P/FCF now vs peer median 43.8xmedian 26.4x 32.5xmedian 26.4x -110.8xmedian 26.4x
P/B now vs peer median 13.9xmedian 2.4x 2.6xmedian 2.4x 24.4xmedian 2.4x
PEG now vs peer median 1.18median 0.99 -2.50median 0.99 -5.01median 0.99

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsILMNRVTYTWST
Revenue $4.54B $2.91B $431.80M
Gross profit $3.08B $1.60B $224.39M
Operating income $960.00M $358.85M -$144.98M
Net income – $237.55M -$136.80M
Free cash flow – $568.85M -$98.12M
R&D $975.00M $215.83M $71.86M
EPS (diluted) $5.85 $2.13 $-2.19
Cash & equivalents $1.29B $1.02B $117.44M
Total debt – $3.21B $15.00M
Shares (diluted) 153.00M 111.63M 62.40M
Enterprise value $35.91B $13.78B $8.87B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricILMNRVTYTWST
P/E 48.9x 77.9x -79.1x
P/FCF 43.8x 32.5x -110.8x
P/Operating cash flow 35.6x 29.0x -204.8x
P/S 9.7x 6.4x 25.2x
P/B 13.9x 2.6x 24.4x
P/Tangible book 15.9x 3.7x 25.1x
EV/EBITDA – 26.7x -89.6x
EV/EBIT – 57.6x -73.9x
EV/Revenue 9.7x 7.1x 24.8x
EV/FCF – 36.4x -109.2x
EV/Operating cash flow 35.6x 32.4x -202.0x
PEG (3Y EPS CAGR) 1.18 -2.50 -5.01

Growth

14 metrics
MetricILMNRVTYTWST
Revenue growth (1Y) 5.8% 4.1% 19.2%
Revenue CAGR (3Y) -0.7% 0.9% 22.4%
Gross profit growth (1Y) 8.5% 2.3% 25.8%
Gross profit CAGR (3Y) 4.4% -0.4% 35.1%
Operating income growth (1Y) 23.1% -5.5% -1.8%
Operating income CAGR (3Y) 30.0% -3.7% 13.5%
Net income growth (1Y) – -16.7% -60.6%
Net income CAGR (3Y) – -33.8% 13.2%
EPS growth (1Y) 28.3% -12.3% -57.5%
EPS CAGR (3Y) 41.3% -31.2% 15.8%
Operating cash flow growth (1Y) 9.6% 6.2% -3.8%
Operating cash flow CAGR (3Y) 47.5% 86.9% 24.4%
Free cash flow growth (1Y) – 9.5% -42.8%
Free cash flow CAGR (3Y) – 64.8% 15.9%

Profitability

14 metrics
MetricILMNRVTYTWST
Gross margin – 55.0% 52.0%
EBITDA margin – 26.6% -27.7%
Operating margin – 12.3% -33.6%
Pretax margin – 9.0% -31.5%
Net margin – 8.2% -31.7%
FCF margin – 19.5% -22.7%
Operating cash flow margin 27.1% 21.9% -12.3%
Return on equity 29.9% 3.3% -30.4%
Return on assets 13.3% 2.0% -20.3%
Return on invested capital – 3.1% -31.1%
Return on capital employed – 3.3% -26.2%
Asset turnover 0.7x 0.2x 0.6x
Cash conversion (OCF / net income) – 2.7x 0.4x
Stock comp / revenue – 0.8% 15.4%

Financial Health

11 metrics
MetricILMNRVTYTWST
Debt / assets – 26.6% 2.2%
Debt / equity – 0.4x 0.0x
Net debt / EBITDA – 2.8x 1.3x
Debt / FCF – 5.6x -0.2x
Liabilities / assets – 40.0% 33.7%
Equity / assets 46.2% 60.0% 66.3%
Interest coverage – 3.7x –
Current ratio 2.6x 1.8x 2.7x
Quick ratio – 1.4x 1.9x
Cash ratio – 0.8x 1.4x
Altman Z-score – 3.46 26.09

Shareholder Returns

7 metrics
MetricILMNRVTYTWST
Dividend yield – 0.2% –
Net buyback yield – 2.5% -0.1%
Shareholder yield – 2.7% -0.1%
Payout ratio (earnings) – 13.4% –
Payout ratio (FCF) – 5.6% –
Dividend growth (1Y) – -6.3% –
Dividend CAGR (3Y) – -6.1% –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusILMNRVTYTWST
Forward P/E 58.1xFY2026 32.5xFY2026 –
EPS, next fiscal year $4.99FY2026 $5.10FY2026 $-2.02FY2026
EPS growth, next FY +3.1%FY2026 +0.8%FY2026 –
EPS growth, the year after +25.7% +11.0% –
Revenue, next fiscal year $4.52BFY2026 $2.98BFY2026 $469.33MFY2026
Revenue growth, next FY +4.1%FY2026 +4.0%FY2026 +24.6%FY2026
Revenue growth, the year after +12.0% -2.0% +21.5%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersILMNRVTYTWST
Held by institutions 100.0% 100.0% 100.0%
Institutions holding 934 546 336
Change in shares held, QoQ +0.0% -1.3% -0.8%
Institutions buying 464 302 189
Institutions selling 330 161 102
Buyers to sellers 1.41 1.88 1.85

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

ILMNRVTYTWST
ILMN 1.00 0.55 0.48
RVTY 0.55 1.00 0.53
TWST 0.48 0.53 1.00

Add a Peer

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Frequently Asked Questions

Which is bigger, ILMN, RVTY and TWST?

Illumina (ILMN) is the largest by market capitalisation: Illumina (ILMN) $35.91B, Revvity (RVTY) $17.52B, Twist Bioscience (TWST) $9.63B.

Which stock is cheaper, ILMN, RVTY and TWST?

Illumina (ILMN) trades on the lowest price-to-earnings ratio (Illumina (ILMN) 40.1x, Revvity (RVTY) 73.7x, Twist Bioscience (TWST) -70.4x). On next year's consensus earnings, Revvity (RVTY) is cheapest (Illumina (ILMN) 58.1x, Revvity (RVTY) 32.5x). A lower multiple can reflect slower expected growth, so read it next to the growth figures.

Which company is growing faster?

Twist Bioscience (TWST) grew revenue fastest over the trailing twelve months: Illumina (ILMN) +5.8%, Revvity (RVTY) +4.1%, Twist Bioscience (TWST) +19.2%.

Which company is more profitable?

Revvity (RVTY) has the highest net margin (Revvity (RVTY) 8.2%, Twist Bioscience (TWST) -31.7%). On return on invested capital, Revvity (RVTY) leads (Revvity (RVTY) 3.1%, Twist Bioscience (TWST) -31.1%).

Which stock has performed better?

Over the past year Twist Bioscience (TWST) returned the most: Illumina (ILMN) +205.2%, Revvity (RVTY) +74.0%, Twist Bioscience (TWST) +438.5%. Over five years, Twist Bioscience (TWST) compounded fastest (Illumina (ILMN) -6.4%/yr, Revvity (RVTY) -1.3%/yr, Twist Bioscience (TWST) +7.9%/yr). Returns are price only, before dividends.

Which pays a higher dividend?

Only one of these companies pays a dividend: Illumina (ILMN) 0.00%, Revvity (RVTY) 0.00%, Twist Bioscience (TWST) 0.00%. Illumina (ILMN) and Twist Bioscience (TWST) pays no regular dividend.

Which stock is riskier?

By one-year price volatility, Revvity (RVTY) has been the steadiest (Illumina (ILMN) 50.3%, Revvity (RVTY) 39.8%, Twist Bioscience (TWST) 79.0%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, ILMN, RVTY and TWST?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Revvity (RVTY) leads on 4. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.