ILMN vs RGEN vs TXG Stock Comparison

Illumina, Repligen and 10x Genomics Prices as of Nov 2, 2026 Peers: Industry group
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ILMN Illumina, Inc.
$226.58 -17.0% 1M +83.4% 1Y
Market cap
$34.21B
P/E
38.2x
Revenue (TTM)
$4.54B
Div. yield
–
Life Sciences Tools Healthcare
5 wins
RGEN Repligen Corp
$172.95 -4.8% 1M +16.0% 1Y
Market cap
$9.76B
P/E
–
Revenue (TTM)
$805.61M
Div. yield
–
Life Sciences Tools Healthcare
4 wins
TXG 10x Genomics, Inc.
$61.63 -34.1% 1M +351.8% 1Y
Market cap
$8.03B
P/E
–
Revenue (TTM)
$616.91M
Div. yield
–
Life Sciences Tools Healthcare
1 win

Head to Head

10 decided of 12

Illumina leads on 5 of the 12 questions below (Illumina 5, Repligen 4, 10x Genomics 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionILMNRGENTXGLeader
Larger companyMarket capitalisation $34.21B $9.76B $8.03B ILMN
Cheaper on earningsLower P/E, profitable companies only 38.2x -826.6x -106.6x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS 45.4x 89.1x — ILMN
Faster revenue growthRevenue growth, trailing twelve months +5.8% +13.8% -4.3% RGEN
More profitableNet margin, trailing twelve months 19.7% -1.5% -12.2% ILMN
Better return on capitalReturn on invested capital 16.6% 0.0% — ILMN
Less leveragedLower net debt / EBITDA 0.4x -2.8x — RGEN
Higher dividend yieldTrailing dividend yield — — — –
Better 1-year returnPrice return, last 12 months +83.4% +16.0% +351.8% TXG
Better 5-year returnAnnualised price return, 5 years -11.1%/yr -10.0%/yr -17.8%/yr RGEN
Less volatileAnnualised volatility, 1 year 49.9% 46.5% 76.6% RGEN
Higher overall scoreMean of the five percentile scores vs peers 75/100 54/100 61/100 ILMN

Percentile Scorecard

ILMNRGENTXG

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisILMNRGENTXG
Valuation 59 #94 of 227 51 #111 of 227 45 #125 of 227
Growth 73 #60 of 220 25 #165 of 220 66 #76 of 220
Profitability 99 #4 of 209 66 #71 of 209 62 #81 of 209
Financial Health 60 #96 of 240 80 #49 of 240 68 #78 of 240
Shareholder Returns 82 #26 of 138 50 #70 of 138 66 #48 of 138
Overall 75 54 61
  • ILMN ranked among 247 companies in Medical Devices and Diagnostics
  • RGEN ranked among 247 companies in Medical Devices and Diagnostics
  • TXG ranked among 247 companies in Medical Devices and Diagnostics

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodILMNRGENTXGSPY
1 month -17.0%-4.8%-34.1% -2.3%
3 months +14.3%+17.6%+31.1% -0.7%
6 months +62.6%+46.3%+184.7% +4.8%
Year to date +72.8%+5.5%+277.9% +10.3%
1 year +83.4%+16.0%+351.8% +10.3%
3 years +99.2%+15.0%+55.2% +73.0%
3 years, per year +25.8%+4.8%+15.8% +20.1%
5 years -44.5%-40.8%-62.5% +61.9%
5 years, per year -11.1%-10.0%-17.8% +10.1%
10 years +71.7%+512.4%— +258.6%
10 years, per year +5.6%+19.9%— +13.6%

Risk

MeasureILMNRGENTXGSPY
Volatility, 1Y 49.9%46.5%76.6% 12.8%
Downside volatility, 1Y 49.1%46.9%72.1% 12.8%
Beta vs S&P 500, 1Y 1.061.262.39 1.00
Return / volatility, 1Y 1.670.344.59 0.80
Max drawdown, 5Y -82.9%-64.8%-96.1% -25.4%
From 52-week high -22.9%-11.1%-36.9% -3.5%
52-week high $293.69$194.57$97.74 $779.14
52-week low $114.44$102.87$13.00 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleILMNRGENTXG
P/E now vs peer median 38.2xmedian 28.4x -826.6xmedian 28.4x -106.6xmedian 28.4x
P/S now vs peer median 7.5xmedian 3.0x 12.1xmedian 3.0x 13.0xmedian 3.0x
EV/EBITDA now vs peer median 28.0xmedian 18.0x 86.2xmedian 18.0x -179.7xmedian 18.0x
P/FCF now vs peer median 32.4xmedian 25.0x 91.4xmedian 25.0x 66.1xmedian 25.0x
P/B now vs peer median 10.9xmedian 2.3x 4.7xmedian 2.3x 9.7xmedian 2.3x
PEG now vs peer median 0.93median 0.93 29.08median 0.93 -3.97median 0.93

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsILMNRGENTXG
Revenue $4.54B $805.61M $616.91M
Gross profit $3.08B $430.67M $432.03M
Operating income $960.00M $18.24M -$88.38M
Net income $895.00M -$11.80M -$75.13M
Free cash flow $1.06B $106.72M $121.44M
R&D $975.00M $57.23M $226.80M
EPS (diluted) $5.85 $-0.21 $-0.58
Cash & equivalents $1.29B $726.96M –
Total debt $1.79B $555.60M –
Shares (diluted) 153.00M 56.64M 129.98M
Enterprise value $28.92B $6.53B $7.83B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricILMNRGENTXG
P/E 38.2x -826.6x -106.6x
P/FCF 32.4x 91.4x 66.1x
P/Operating cash flow 27.8x 75.1x 63.2x
P/S 7.5x 12.1x 13.0x
P/B 10.9x 4.7x 9.7x
P/Tangible book 12.4x 5.5x 10.5x
EV/EBITDA 28.0x 86.2x -179.7x
EV/EBIT 36.1x 518.2x -90.3x
EV/Revenue 7.6x 11.7x 12.9x
EV/FCF 32.8x 88.6x 65.7x
EV/Operating cash flow 28.2x 72.8x 62.8x
PEG (3Y EPS CAGR) 0.93 29.08 -3.97

Growth

14 metrics
MetricILMNRGENTXG
Revenue growth (1Y) 5.8% 13.8% -4.3%
Revenue CAGR (3Y) -0.7% 7.3% 2.8%
Gross profit growth (1Y) 8.5% 33.0% -3.5%
Gross profit CAGR (3Y) 4.4% 13.3% 1.1%
Operating income growth (1Y) 23.1% 2,185% 12.1%
Operating income CAGR (3Y) 30.0% -40.5% 20.9%
Net income growth (1Y) 27.5% -779.2% 11.2%
Net income CAGR (3Y) 40.9% -28.4% 24.2%
EPS growth (1Y) 28.3% -777.9% 14.9%
EPS CAGR (3Y) 41.3% -28.4% 26.8%
Operating cash flow growth (1Y) 9.6% -0.8% 89.8%
Operating cash flow CAGR (3Y) 47.5% -4.0% 135.5%
Free cash flow growth (1Y) 5.7% -3.0% 113.5%
Free cash flow CAGR (3Y) 126.5% 1.8% 44.7%

Profitability

14 metrics
MetricILMNRGENTXG
Gross margin 67.9% 53.5% 70.0%
EBITDA margin 27.3% 13.6% -7.2%
Operating margin 21.2% 2.3% -14.3%
Pretax margin 23.3% 1.0% -12.1%
Net margin 19.7% -1.5% -12.2%
FCF margin 23.3% 13.2% 19.7%
Operating cash flow margin 27.1% 16.1% 20.6%
Return on equity 29.9% -0.6% -9.2%
Return on assets 13.3% -0.4% -7.3%
Return on invested capital 16.6% 0.0% –
Return on capital employed 17.2% 0.6% -9.8%
Asset turnover 0.7x 0.3x 0.6x
Cash conversion (OCF / net income) 1.4x -11.0x -1.7x
Stock comp / revenue 5.9% 4.2% 16.0%

Financial Health

11 metrics
MetricILMNRGENTXG
Debt / assets 26.3% 19.0% –
Debt / equity 0.6x 0.3x –
Net debt / EBITDA 0.4x -2.8x –
Debt / FCF 1.7x 5.2x –
Liabilities / assets 53.8% 28.5% 19.9%
Equity / assets 46.2% 71.5% 80.1%
Interest coverage 9.8x 0.8x –
Current ratio 2.6x 9.9x 5.7x
Quick ratio 1.8x 8.1x 0.8x
Cash ratio 1.2x 6.9x 0.4x
Altman Z-score 7.10 7.98 22.42

Shareholder Returns

7 metrics
MetricILMNRGENTXG
Dividend yield – – –
Net buyback yield 1.1% -0.2% -0.1%
Shareholder yield 1.1% -0.2% -0.1%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusILMNRGENTXG
Forward P/E 45.4xFY2026 89.1xFY2026 –
EPS, next fiscal year $4.99FY2026 $1.94FY2026 $-0.79FY2026
EPS growth, next FY +3.1%FY2026 +13.5%FY2026 –
EPS growth, the year after +25.7% +29.4% –
Revenue, next fiscal year $4.52BFY2026 $773.94MFY2026 $580.42MFY2026
Revenue growth, next FY +4.1%FY2026 +4.8%FY2026 -9.7%FY2026
Revenue growth, the year after +12.0% +35.9% +24.6%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersILMNRGENTXG
Held by institutions 100.0% 100.0% 98.4%
Institutions holding 935 483 391
Change in shares held, QoQ +0.0% +1.2% +2.4%
Institutions buying 464 273 198
Institutions selling 331 141 137
Buyers to sellers 1.40 1.94 1.45

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

ILMNRGENTXG
ILMN 1.00 0.45 0.56
RGEN 0.45 1.00 0.49
TXG 0.56 0.49 1.00

Add a Peer

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Frequently Asked Questions

Which is bigger, ILMN, RGEN and TXG?

Illumina (ILMN) is the largest by market capitalisation: Illumina (ILMN) $34.21B, Repligen (RGEN) $9.76B, 10x Genomics (TXG) $8.03B.

Which company is growing faster?

Repligen (RGEN) grew revenue fastest over the trailing twelve months: Illumina (ILMN) +5.8%, Repligen (RGEN) +13.8%, 10x Genomics (TXG) -4.3%.

Which company is more profitable?

Illumina (ILMN) has the highest net margin (Illumina (ILMN) 19.7%, Repligen (RGEN) -1.5%, 10x Genomics (TXG) -12.2%). On return on invested capital, Illumina (ILMN) leads (Illumina (ILMN) 16.6%, Repligen (RGEN) 0.0%).

Which stock has performed better?

Over the past year 10x Genomics (TXG) returned the most: Illumina (ILMN) +83.4%, Repligen (RGEN) +16.0%, 10x Genomics (TXG) +351.8%. Over five years, Repligen (RGEN) compounded fastest (Illumina (ILMN) -11.1%/yr, Repligen (RGEN) -10.0%/yr, 10x Genomics (TXG) -17.8%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Repligen (RGEN) has been the steadiest (Illumina (ILMN) 49.9%, Repligen (RGEN) 46.5%, 10x Genomics (TXG) 76.6%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, ILMN, RGEN and TXG?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Illumina (ILMN) leads on 5. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.