CRSP vs IMTX vs SRPT Stock Comparison

CRISPR Therapeutics AG, Immatics and Sarepta Therapeutics Prices as of Oct 29, 2026 Peers: Industry group
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CRSP CRISPR Therapeutics AG
$54.26 -3.1% 1M -13.3% 1Y
Market cap
$4.97B
P/E
–
Revenue (TTM)
$13.39M
Div. yield
–
Gene and Cell Therapy Healthcare
4 wins
IMTX Immatics N.V.
$7.31 -14.6% 1M -29.3% 1Y
Market cap
$842.98M
P/E
–
Revenue (TTM)
$48.61M
Div. yield
–
Gene and Cell Therapy Healthcare

Head to Head

9 decided of 12

Sarepta Therapeutics leads on 5 of the 12 questions below (Sarepta Therapeutics 5, CRISPR Therapeutics AG 4). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionCRSPIMTXSRPTLeader
Larger companyMarket capitalisation $4.97B $842.98M $1.97B CRSP
Cheaper on earningsLower P/E, profitable companies only -11.0x -3.5x -16.8x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — — 6.7x –
Faster revenue growthRevenue growth, trailing twelve months -64.8% -65.4% -20.4% SRPT
More profitableNet margin, trailing twelve months -3,368.7% -495.7% -5.9% SRPT
Better return on capitalReturn on invested capital -22.6% — -6.1% SRPT
Less leveragedLower net debt / EBITDA 3.4x — -0.6x SRPT
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months -13.3% -29.3% -18.0% CRSP
Better 5-year returnAnnualised price return, 5 years -9.9%/yr -12.6%/yr -24.7%/yr CRSP
Less volatileAnnualised volatility, 1 year 57.3% 57.6% 81.1% CRSP
Higher overall scoreMean of the five percentile scores vs peers 45/100 36/100 67/100 SRPT

Percentile Scorecard

CRSPIMTXSRPT

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisCRSPIMTXSRPT
Valuation 51 #308 of 624 29 #442 of 624 97 #23 of 624
Growth 32 #412 of 601 4 #577 of 601 64 #220 of 601
Profitability 32 #367 of 541 45 #296 of 541 80 #111 of 541
Financial Health 71 #188 of 647 75 #166 of 647 34 #430 of 647
Shareholder Returns 38 #222 of 359 25 #268 of 359 61 #141 of 359
Overall 45 36 67
  • CRSP ranked among 671 companies in Pharmaceuticals and Biotechnology
  • IMTX ranked among 671 companies in Pharmaceuticals and Biotechnology
  • SRPT ranked among 671 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodCRSPIMTXSRPTSPY
1 month -3.1%-14.6%+3.2% +0.7%
3 months +12.0%-20.5%+23.6% +3.7%
6 months +3.7%-33.5%-7.9% +7.1%
Year to date +3.5%-30.4%-10.6% +12.8%
1 year -13.3%-29.3%-18.0% +11.9%
3 years +39.4%-0.7%-82.1% +85.2%
3 years, per year +11.7%-0.2%-43.7% +22.8%
5 years -40.6%-49.0%-75.7% +67.6%
5 years, per year -9.9%-12.6%-24.7% +10.9%
10 years +224.1%—-53.0% +262.0%
10 years, per year +12.5%—-7.3% +13.7%

Risk

MeasureCRSPIMTXSRPTSPY
Volatility, 1Y 57.3%57.6%81.1% 12.7%
Downside volatility, 1Y 53.8%59.4%85.8% 12.6%
Beta vs S&P 500, 1Y 1.841.362.08 1.00
Return / volatility, 1Y -0.23-0.51-0.22 0.94
Max drawdown, 5Y -67.7%-75.7%-92.7% -25.4%
From 52-week high -15.2%-38.4%-21.3% -1.2%
52-week high $63.99$11.87$24.45 $779.14
52-week low $44.34$6.73$14.86 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleCRSPIMTXSRPT
P/E now vs peer median -11.6xmedian 17.8x -3.7xmedian 17.8x -17.4xmedian 17.8x
P/S now vs peer median 391.6xmedian 9.1x 20.2xmedian 9.1x 1.0xmedian 9.1x
EV/EBITDA now vs peer median -6.7xmedian 15.0x -2.1xmedian 15.0x -21.2xmedian 15.0x
P/FCF now vs peer median -14.1xmedian 21.7x -4.0xmedian 21.7x 24.8xmedian 21.7x
P/B now vs peer median 3.0xmedian 2.2x 2.1xmedian 2.2x 1.3xmedian 2.2x
PEG now vs peer median -3.01median 0.35 0.16median 0.35 -0.33median 0.35

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsCRSPIMTXSRPT
Revenue $13.39M $48.61M $1.97B
Gross profit – – $1.17B
Operating income -$534.34M -$264.59M -$143.25M
Net income -$451.14M -$240.97M -$136.73M
Free cash flow -$371.33M -$244.28M $81.85M
R&D $278.15M $254.77M $789.44M
EPS (diluted) $-4.67 $-1.97 $-1.11
Cash & equivalents $291.34M $265.52M $571.15M
Total debt $586.20M – $847.62M
Shares (diluted) 96.51M 122.35M 105.43M
Enterprise value -$3.73B -$1.18B -$1.26B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricCRSPIMTXSRPT
P/E -11.6x -3.7x -17.4x
P/FCF -14.1x -4.0x 24.8x
P/Operating cash flow -14.2x -4.1x 18.3x
P/S 391.6x 20.2x 1.0x
P/B 3.0x 2.1x 1.3x
P/Tangible book 3.0x 2.2x 1.4x
EV/EBITDA -6.7x -2.1x -21.2x
EV/EBIT -6.5x -2.0x -14.6x
EV/Revenue 258.9x 10.9x 1.1x
EV/FCF -9.3x -2.2x 25.5x
EV/Operating cash flow -9.4x -2.2x 18.8x
PEG (3Y EPS CAGR) -3.01 0.16 -0.33

Growth

14 metrics
MetricCRSPIMTXSRPT
Revenue growth (1Y) -64.8% -65.4% -20.4%
Revenue CAGR (3Y) -57.1% -47.1% 25.3%
Gross profit growth (1Y) – – -40.7%
Gross profit CAGR (3Y) – – 10.6%
Operating income growth (1Y) 3.3% -176.1% -15,270%
Operating income CAGR (3Y) -4.1% -58.8% 34.5%
Net income growth (1Y) 3.6% -187.4% -135.9%
Net income CAGR (3Y) -2.7% -37.5% 46.8%
EPS growth (1Y) 13.0% -180.7% -215.7%
EPS CAGR (3Y) 3.9% -23.8% 52.3%
Operating cash flow growth (1Y) -13.8% -33.6% 136.9%
Operating cash flow CAGR (3Y) -2.5% -39.1% 30.6%
Free cash flow growth (1Y) -14.1% -29.2% 118.1%
Free cash flow CAGR (3Y) -0.9% -30.7% 29.1%

Profitability

14 metrics
MetricCRSPIMTXSRPT
Gross margin – – 59.1%
EBITDA margin -3,850% -515.5% -5.0%
Operating margin -3,990% -544.3% -7.3%
Pretax margin -3,346% -496.3% -6.6%
Net margin -3,369% -495.7% -5.9%
FCF margin -2,773% -502.6% 4.1%
Operating cash flow margin -2,760% -493.8% 5.6%
Return on equity -25.3% -49.2% -9.0%
Return on assets -16.8% -40.9% -4.3%
Return on invested capital -22.6% – -6.1%
Return on capital employed -20.9% -50.5% -5.3%
Asset turnover 0.0x 0.1x 0.6x
Cash conversion (OCF / net income) 0.8x 1.0x -0.8x
Stock comp / revenue 510.2% 42.1% 6.3%

Financial Health

11 metrics
MetricCRSPIMTXSRPT
Debt / assets 22.1% – 26.6%
Debt / equity 0.3x – 0.6x
Net debt / EBITDA 3.4x – -0.6x
Debt / FCF -1.6x – 10.4x
Liabilities / assets 34.1% 17.7% 52.1%
Equity / assets 65.9% 82.3% 47.9%
Interest coverage – -3.2x –
Current ratio 17.8x 7.5x 4.4x
Quick ratio 17.8x 7.0x 2.4x
Cash ratio 17.8x 6.9x 1.6x
Altman Z-score 2.69 2.80 -0.15

Shareholder Returns

7 metrics
MetricCRSPIMTXSRPT
Dividend yield – – –
Net buyback yield -8.1% -15.4% -1.1%
Shareholder yield -8.1% -15.4% -1.1%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusCRSPIMTXSRPT
Forward P/E – – 6.7xFY2026
EPS, next fiscal year $-4.10FY2026 $-2.10FY2026 $2.88FY2026
EPS growth, the year after – – -88.5%
Revenue, next fiscal year $38.73MFY2026 $40.64MFY2026 $1.76BFY2026
Revenue growth, next FY +1,003.4%FY2026 -28.4%FY2026 -20.1%FY2026
Revenue growth, the year after +266.1% -11.9% -21.5%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersCRSPIMTXSRPT
Held by institutions 78.9% 81.6% 100.0%
Institutions holding 519 83 325
Change in shares held, QoQ -1.0% -7.8% +4.5%
Institutions buying 238 37 148
Institutions selling 139 33 116
Buyers to sellers 1.71 1.12 1.28

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

CRSPIMTXSRPT
CRSP 1.00 0.33 0.39
IMTX 0.33 1.00 0.37
SRPT 0.39 0.37 1.00

Add a Peer

Largest companies in the same industry

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Frequently Asked Questions

Which is bigger, CRSP, IMTX and SRPT?

CRISPR Therapeutics AG (CRSP) is the largest by market capitalisation: CRISPR Therapeutics AG (CRSP) $4.97B, Immatics (IMTX) $842.98M, Sarepta Therapeutics (SRPT) $1.97B.

Which company is growing faster?

Sarepta Therapeutics (SRPT) grew revenue fastest over the trailing twelve months: CRISPR Therapeutics AG (CRSP) -64.8%, Immatics (IMTX) -65.4%, Sarepta Therapeutics (SRPT) -20.4%.

Which company is more profitable?

Sarepta Therapeutics (SRPT) has the highest net margin (CRISPR Therapeutics AG (CRSP) -3,368.7%, Immatics (IMTX) -495.7%, Sarepta Therapeutics (SRPT) -5.9%). On return on invested capital, Sarepta Therapeutics (SRPT) leads (CRISPR Therapeutics AG (CRSP) -22.6%, Sarepta Therapeutics (SRPT) -6.1%).

Which stock has performed better?

Over the past year CRISPR Therapeutics AG (CRSP) returned the most: CRISPR Therapeutics AG (CRSP) -13.3%, Immatics (IMTX) -29.3%, Sarepta Therapeutics (SRPT) -18.0%. Over five years, CRISPR Therapeutics AG (CRSP) compounded fastest (CRISPR Therapeutics AG (CRSP) -9.9%/yr, Immatics (IMTX) -12.6%/yr, Sarepta Therapeutics (SRPT) -24.7%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, CRISPR Therapeutics AG (CRSP) has been the steadiest (CRISPR Therapeutics AG (CRSP) 57.3%, Immatics (IMTX) 57.6%, Sarepta Therapeutics (SRPT) 81.1%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, CRSP, IMTX and SRPT?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Sarepta Therapeutics (SRPT) leads on 5. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.